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Author: Giulio Agnetti
Publisher: Springer
ISBN: 3319318284
Category : Medical
Languages : en
Pages : 442
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Book Description
This book fulfils the need to keep up with the high number of innovations in proteomics, and at the same time to warn the readers about the danger of manufacturers and scientists claims around new technologies. Mass spectrometry stands as the core technology in proteomics. The emerging field of targeted proteomics and its potential applications in the cardiovascular arena are also reviewed and discussed. A concluding section highilghts the promise of proteomics in the light of these recent developments. As this technique and its applications have undergone remarkable advances in the past years, recent updates on proteomic applications are covered. Another key concept revealed by proteomic technologies is that the extent of protein post-translational modifications (PTMs) as well as their impact on the phenotype has been underestimated by pre-proteomics science. As such, part of the manual focuses on the emerging role of PTMs in basic cardiovascular sciences and in the clinics. In fact, there is an emerging consensus that the detailed annotation of protein PTMs could lead to a more in-depth representation of biological systems, translating into more specific targets for therapy as well as biomarkers. Moreover, a recent trend is so-called “targeted proteomics”. The approach was awarded the title of “Method of the Year” by Nature in 2013 (see the editorial by Vivien Marx in 1st issue of Nature in Jan 2013). According to a few proteomic scientists the emphasis should not be placed on generating long lists of proteins but lists of proteins with a true biological meaning.
Author: Giulio Agnetti
Publisher: Springer
ISBN: 3319318284
Category : Medical
Languages : en
Pages : 442
Get Book Here
Book Description
This book fulfils the need to keep up with the high number of innovations in proteomics, and at the same time to warn the readers about the danger of manufacturers and scientists claims around new technologies. Mass spectrometry stands as the core technology in proteomics. The emerging field of targeted proteomics and its potential applications in the cardiovascular arena are also reviewed and discussed. A concluding section highilghts the promise of proteomics in the light of these recent developments. As this technique and its applications have undergone remarkable advances in the past years, recent updates on proteomic applications are covered. Another key concept revealed by proteomic technologies is that the extent of protein post-translational modifications (PTMs) as well as their impact on the phenotype has been underestimated by pre-proteomics science. As such, part of the manual focuses on the emerging role of PTMs in basic cardiovascular sciences and in the clinics. In fact, there is an emerging consensus that the detailed annotation of protein PTMs could lead to a more in-depth representation of biological systems, translating into more specific targets for therapy as well as biomarkers. Moreover, a recent trend is so-called “targeted proteomics”. The approach was awarded the title of “Method of the Year” by Nature in 2013 (see the editorial by Vivien Marx in 1st issue of Nature in Jan 2013). According to a few proteomic scientists the emphasis should not be placed on generating long lists of proteins but lists of proteins with a true biological meaning.
Author: Nathan D. Wong
Publisher: Springer Nature
ISBN: 3030562794
Category : Medical
Languages : en
Pages : 766
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Book Description
This second edition provides an updated review on the current guidelines and practice standards for the clinical management of cardiovascular risk factors and prevention of cardiovascular diseases. Endorsed by the American Society for Preventive Cardiology, this practical textbook includes concise descriptions of major and newer risk factors, biomarkers, and best practices in the management and prevention of cardiovascular disease. The manual contains chapters on the epidemiology and risk factors for a variety of cardiovascular diseases including dyslipidemia, hypertension, diabetes, inflammation, and ischemic stroke. It examines behavioral factors, psychosocial stress, family history, nutrition, physical activity, smoking, alcohol use, and other sociocultural factors. In addition, the book discusses new imaging strategies in detection of cardiovascular disease, prevention of heart failure, atrial fibrillation, and peripheral arterial disease, and prevention for special populations. Throughout the manual, recommendations are based on guidelines endorsed by the American College of Cardiology, American Heart Association, and other major societies. The second edition of the ASPC Manual of Preventive Cardiology is an essential resource for physicians, medical students, residents, fellows, nurses, and other healthcare professionals and researchers in cardiology, primary care, health promotion and disease prevention, exercise physiology, and pharmacotherapy.
Author: Monte S. Willis
Publisher: Springer
ISBN: 3319981439
Category : Medical
Languages : en
Pages : 474
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Book Description
Fibroproliferative diseases are a broad spectrum of entities from organ-specific involvement (e.g., pulmonary, heart, liver, and kidney fibrosis) to multi-system diseases such as systemic sclerosis and sclerodermatous graft vs. host disease. These diseases also encompass pathophysiologies not readily recognizably related, such as macular degeneration and cancer metastasis. Fibroproliferative diseases are a leading cause of morbidity and mortality and can affect all tissues and organ systems. Remarkable progress in elucidating the pathogenesis of these common diseases with fibrotic components, including the critical roles of myofibroblasts and the molecular mechanisms driving the transcriptional activation involved in the induction of fibrosis. As the importance of these processes is realized in the long-term recovery and treatment of diseases, effective anti-fibrotic therapies targeting the underlying ongoing disease processes are lacking. The complexity of discovering and applying therapies to fibroproliferative disease may be due to the diversity of the systems the pathogenesis of disease itself involves. By nature, fibroproliferative diseases are interdisciplinary, involving multiple cell types (organ-specific epithelial cells), immune cells, endothelial cells, and fibroblasts. Bone marrow, cytokines, and organ-specific pathologies further speckle both the clinical and scientific disciplines in such a way that communication is often limited to the clinical or scientific tribes we live in, despite the greatest access to information known to man available today. Therefore, the primary focus of this text is to bring together authors from a diversity of both clinical, scientific, and therapeutic backgrounds for readers to more fully appreciate that fantastic platform that is available to build upon to lessen the isolation of the clinical and scientific disciplines. With advances in the discovery of pre-clinical therapeutic targets (at least 20+ to date) involving TGF-beta (and other cytokines), transcription factors, and downstream kinases, it’s important to both recognize the broader impact and potential opportunities that exist even today. This book will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of fibroproliferative diseases. The book will provide new insight into the fundamental mechanisms of classic fibrotic pathophysiologic processes like myocardial infarction, idiopathic pulmonary fibrosis, chronic kidney disease, wound healing, and systemic sclerosis. It will also highlight the many new areas of therapeutic investigation currently underway. Lastly, we will touch upon newly emerging fields investigating the role of fibrosis in macular degeneration and cancer metastasis. The chapters will be written by established experts in their fields, including clinicians (cardiologists, cardiovascular surgeons, pathologists, and general practitioners) and translational biomedical researchers in a wide range of disciplines. However, the material will certainly have a broader audience including medical residents, fellows, and general practitioners as well as M.D. or Ph.D. post-doctoral research fellows. While comprehensive, we'll attempt to present the material in a manner that simplifies the complex pathophysiologic mechanisms that underlie common fibroproliferative diseases while making it appealing to a broad audience.
Author: Peter L. Thompson
Publisher: Elsevier Health Sciences
ISBN: 0729579271
Category : Medical
Languages : en
Pages : 737
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Book Description
The Coronary Care Manual has been designed as a practical manual for the management of the acute coronary patient, and aims to achieve a balance between the large and rapidly changing evidence base and practical application in the CCU, ICU, ED and ambulance. The book has been written by a group of Australian and international experts for medical, nursing and paramedic staff working in these areas. This edition covers a broad range of coronary care medicine in enough detail to eliminate the need to refer to a larger reference book, providing a portable companion for a night "on call". Completely redesigned with new artwork, the manual is organized to suit academics and practitioners alike. • covers a broad range of coronary care medicine• provides specific advice on the management of common clinical problems• eliminates the need to refer to a larger reference book• features a consistent style and focus, with standardised artwork for figures• is now also available as an eBook! A code inside the Coronary Care Manual enables a full text download, allowing you to browse and search electronically, make notes and bookmarks in the electronic files and highlight material
Author: Fernando Vivanco
Publisher: Springer Science & Business Media
ISBN: 1597452149
Category : Science
Languages : en
Pages : 412
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Book Description
This cutting-edge book presents protocols and strategies for proteomic evaluation of cardiovascular disease written by pioneering researchers in the field. Topics explored in this comprehensive volume include obtaining specific heart proteins, techniques for identifying risk biomarkers of atherome plaque rupture, analyzing the secretome of explanted endarterectomies cultured in vitro, and phage display techniques for deciphering the molecular diversity of blood vessels.
Author: Aldostefano Porcari
Publisher: Frontiers Media SA
ISBN: 2832531245
Category : Medical
Languages : en
Pages : 107
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Book Description
Author: Mohd Imtiaz Nawaz
Publisher: Frontiers Media SA
ISBN: 2832535534
Category : Medical
Languages : en
Pages : 260
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Book Description
Author: Pankaj Talwar
Publisher: JP Medical Ltd
ISBN: 9350909928
Category : Medical
Languages : en
Pages : 331
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Book Description
Cytogenetics is the study of the structure and function of the cell, particularly chromosomes. Manual of Cytogenetics in Reproductive Biology examines the diagnostic role of cytogenetics in improving the outcome of assisted reproductive technologies (ART). Divided into six sections, the book begins with the basics of genetics, followed by investigative cytogenetics, applied cytogenetics, recent advances, preimplantation and prenatal cytogenetics. This comprehensive guide includes nearly 200 clinical images, diagrams and tables, and is an invaluable reference for practising specialists in genetics, infertility and obstetrics and gynaecology. Key points Examines diagnostic role of cytogenetics in improving outcome of ART Six sections each providing in depth coverage of different aspects of cytogenetics Includes nearly 200 clinical images, diagrams and tables Invaluable for specialists in genetics, infertility and OBSGY
Author: Richa Baharani
Publisher: JP Medical Ltd
ISBN: 9352703928
Category : Medical
Languages : en
Pages : 466
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Book Description
This book is a comprehensive guide to the assessment and management of high risk pregnancy. Divided into eleven sections, the text begins with discussion on antenatal care, nutrition, genetic screening and ultrasonography-guided interventions in pregnancy. The following sections cover different factors that cause a pregnancy to be high risk including haematological disorders, early pregnancy complications, medical disorders such as gestational diabetes and cardiac disease, obstetric complications such as eclampsia and preterm labour, infections, foetal growth problems, and autoimmune diseases. The finals chapters discuss delivery complications and miscellaneous topics such as intrauterine foetal death, cerebrovascular accidents, ART pregnancies, and medicolegal aspects. The book is further enhanced by clinical photographs, diagrams and tables. Key points Comprehensive guide to management of high risk pregnancy Detailed discussion on screening and prevention of complications Presents recent advances in the field Highly illustrated with clinical photographs, diagrams and tables
Author: Hubert Rehm
Publisher: Elsevier
ISBN: 0080458432
Category : Science
Languages : en
Pages : 252
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Book Description
Hubert Rehm's Protein Biochemistry and Proteomics is more than a laboratory manual; it is a strategic guide that provides the reader with tips and tricks for more successful lab experiments. Using a conversational yet professional tone, Rehm provides an overview of a variety of methods in protein biochemistry/proteomics. He provides short and precise summaries of routine procedures as well as listings of the advantages and disadvantages of alternative methods. Readers will immediately sense that the author if very familiar with the challenges, and frustration of the daily lab routine. Never before has such an honest, tactical guide been available for those conducting lab experiments within the field of biochemistry. - Shows how to avoid experimental dead ends and helps users develop an instinct for the right experiment at the right time - Contains short and precise summaries of routine procedures (e.g. column chromatography, gel electrophoresis), and lists the advantages and disadvantages of alternative methods - Includes over 100 detailed figures and tables - Contains a chapter on proteomics
