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Author: Mohamed Abou-Donia
Publisher: John Wiley & Sons
ISBN: 1119940419
Category : Medical
Languages : en
Pages : 716
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Book Description
Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.
Author: Mohamed Abou-Donia
Publisher: John Wiley & Sons
ISBN: 1119940419
Category : Medical
Languages : en
Pages : 716
Get Book
Book Description
Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.
Author: Timothy C. Marrs
Publisher: Royal Society of Chemistry
ISBN: 1849731918
Category : Science
Languages : en
Pages : 507
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Book Description
Insects are more similar in structure and physiology to mammals than plants or fungi. Consequently, insecticides are often of greater toxicity to mammals than herbicides. This is particularly the case with neurotoxins. However, some insecticides are targeted at structures or hormonal systems specific to insects (insect growth regulators/chitin synthesis inhibitors) so are less harmful but can still be mildly haematotoxic. There are, therefore, issues specific to insecticides, which do not occur with other pesticides - hence the need for a book specifically on insecticide toxicology in mammals. The book starts with general issues relating to the mammalian toxicity of insecticides, including target/non-target specificity, nomenclature and metabolism of insecticides. It then goes on to discuss specific types of insecticides including: organochlorines; anticholinesterases; pyrethrum and synthetic pyrethroids; nicotine and the neonicotinoids; insect growth regulators/ecdysone agonists/chitin synthesis inhibitors; insecticides of natural origin; biological insecticides; and insecticides used in veterinary medicine.
Author: E. E. Kenaga
Publisher: ASTM International
ISBN:
Category : Birds
Languages : en
Pages : 106
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Book Description
Author: Donald Wayne Lamb
Publisher: ASTM International
ISBN: 9780803107595
Category : Medical
Languages : en
Pages : 178
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Book Description
Author: Richard F. Shore
Publisher: John Wiley & Sons
ISBN:
Category : Nature
Languages : en
Pages : 760
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Book Description
This landmark book, which contains contributions from the world's foremost mammalian ecotoxicologists, is a truly impressive summary of research undertaken in this field in recent years. It is also the first book to draw such information together in a seamless and unified approach. In examining the exposure and effects of environmental contaminants in wild mammal populations, this book addresses four core questions: * What exactly do we know about environmental contaminants in wild mammals? * What are the commonalities and differences between mammal orders/species in the effects that contaminants have? * How and to what degree of accuracy can we predict the adverse effects of environmental contaminants on mammalian wildlife? * How significant are contaminant insults compared with other density-independent and -dependent factors such as habitat loss, climatic factors and disease? The key underlying scientific principles and issues raised by the team of international authors will have significance throughout the world, making this an invaluable book not only for all those studying the effects of environmental pollutants on mammals, but also on regulatory agencies, and those carrying out environmental impact assessment.
Author: Carey N. Pope
Publisher: Academic Press
ISBN: 0128136022
Category : Medical
Languages : en
Pages : 644
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Book Description
An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from "simple” molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included. The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology. Covers major topics and newer areas in toxicology, including nanotoxicology, Tox21, epigenetic toxicology, and organ-specific toxicity Includes a variety of perspectives to give a complete understanding of toxicology Written by specialists within each subject area, e.g., a chemical engineer, to ensure concepts are clearly explained
Author: Joseph G. Vos
Publisher: CRC Press
ISBN: 0203165578
Category : Nature
Languages : en
Pages : 656
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Book Description
The activities of modern society have unleashed a range of toxic chemicals into the global environment. Many of these toxicants are now being detected in increasing quantities in the tissues of marine mammals, most notably in top predators who acquire relatively large amounts of toxic chemicals by ingesting contaminated prey. Toxicology of M
Author: Mohamed Abou-Donia
Publisher: John Wiley & Sons
ISBN: 1118682858
Category : Medical
Languages : en
Pages : 720
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Book Description
Mammalian Toxicology surveys chemical agents and examineshow such chemicals impact on human health, emphasizing theimportance in minimizing environmental exposure to chemical andphysical hazards in our homes, communities and workplaces throughsuch media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxicagents, this textbook describes how they enter the body, theirmechanisms of action once inside, and strategies for diagnosis,prevention and treatment. Topics covered include: General principles of toxicology: pharmacological andtoxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry intothe body and various tissues, storage, metabolic biotransformationand elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body,health effects, toxic mechanisms, antidotes and treatments of arange of agents including pesticides, metals, solvents, gases,nanomaterials, food components and additives, pharmaceuticals,drugs of abuse, natural toxins, endocrine disruptors, radiation,and warfare weapons. Toxic effects: including neurotoxicity, developmentaltoxicity, immunotoxicity, teratogenecity, male and femalereproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity,gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies ofchemical-induced diseases in human populations, and a vision fortoxicology in the 21st century. Mammalian Toxicology is an essential primer for studentsof toxicology, biochemistry, biology, medicine and chemistry. It isalso appropriate for professional toxicologists in research orregulatory affairs, and anyone who needs to understand the adverseeffects of toxic agents on the human body.
Author: D. W. Lamb
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309166411
Category : Science
Languages : en
Pages : 226
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Book Description
The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.
