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Author: Anatoly Ruvinsky
Publisher: CABI
ISBN: 0851999107
Category : Science
Languages : en
Pages : 612
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Book Description
Organization of the Mammalian Genome; Linkage mapping ; Mapping genomes at the chromosome leveI ; Mapping genomes at the molecular level ; DNA sequence of the human and other mammalian genomes; Expression of the Mammalian Genomes ; The transcriptome ; The proteome ; The epigenome: epigenetic reguIation of gene expression in mammalian species ; Regulation of genome activity and genetic networks in mammals ; Inducing alterations in the mammalian genome for investigating the functions : of genes ; Evolution of the Mammalian Genome ; O A comparative analysis of mammalian genomics: prokaryote and eukaryote perspectives ; Elements and mechanisms of genome change ; DNA sequence evolution and phylogenetic footprinting ; Evolution of the mammalian karyotype ; Compara tive gene mapping, chromosome painting and the reconstruction of the ancestral mammalian karyotype ; Genome Analysis and Bioinformatics ; Bioinformatics: from computational analysis through to integrated systems ; Genetic databases ; Gene predictions and annotations ; The Fruits of Mammalian Genomics ; Genomic research and progress in understanding inherited disorders in humans and other mammals ; Pharmacogenomics ; O Genome scanning for quantitative trait loci ; Mammalian popuIation genetics and genomics.
Author: Anatoly Ruvinsky
Publisher: CABI
ISBN: 0851999107
Category : Science
Languages : en
Pages : 612
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Book Description
Organization of the Mammalian Genome; Linkage mapping ; Mapping genomes at the chromosome leveI ; Mapping genomes at the molecular level ; DNA sequence of the human and other mammalian genomes; Expression of the Mammalian Genomes ; The transcriptome ; The proteome ; The epigenome: epigenetic reguIation of gene expression in mammalian species ; Regulation of genome activity and genetic networks in mammals ; Inducing alterations in the mammalian genome for investigating the functions : of genes ; Evolution of the Mammalian Genome ; O A comparative analysis of mammalian genomics: prokaryote and eukaryote perspectives ; Elements and mechanisms of genome change ; DNA sequence evolution and phylogenetic footprinting ; Evolution of the mammalian karyotype ; Compara tive gene mapping, chromosome painting and the reconstruction of the ancestral mammalian karyotype ; Genome Analysis and Bioinformatics ; Bioinformatics: from computational analysis through to integrated systems ; Genetic databases ; Gene predictions and annotations ; The Fruits of Mammalian Genomics ; Genomic research and progress in understanding inherited disorders in humans and other mammals ; Pharmacogenomics ; O Genome scanning for quantitative trait loci ; Mammalian popuIation genetics and genomics.
Author: Stephen J. O'Brien
Publisher: John Wiley & Sons
ISBN: 1119418038
Category : Science
Languages : en
Pages : 1008
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Book Description
THE UPDATED NEW EDITION OF THE POPULAR COLLECTION OF HIGH-RESOLUTION CHROMOSOME PHOTOGRAPHS FOR GENETICISTS, MAMMOLOGISTS, AND BIOLOGISTS INTERESTED IN COMPARATIVE GENOMICS, SYSTEMATICS, AND CHROMOSOME STRUCTURE Filled with a visually exquisite collection of the banded metaphase chromosome karyotypes from some 1,000 species of mammals, the Atlas of Mammalian Chromosomes offers an unabridged compendium of the state of this genomic art form. The Atlas??contains the best karyotype produced, the common and Latin name of the species, the published citation, and identifies the contributing authors. Nearly all karyotypes are G-banded, revealing the chromosomal bar codes of homologous segments among related species. The Atlas brings together information from a range of cytogenetic literature and features high-quality karyotype images for nearly every mammal studied to date. When the Atlas was first published, only three mammals were sequenced. Today, that number is over 300. Now in its second edition, this book contains extensive revisions and major additions such as new karyotypes that employ G- and C- banding to represent euchromatin and heterochromatin genome composition, new phylogenetic trees for each order, homology segment chromosome information on published aligned chromosome painting. Summaries of the painting data for some species indicate conserved homology segments among compared species. An invaluable resource for today's comparative genomics era, this comprehensive collection of high-resolution chromosome photographs: Assembles information previously scattered throughout the cytogenetics literature in one comprehensive volume Provides chromosome information and illustrations for the karyotypes of 300 new species Addresses the mandate of the Human Genome Project to annotate the genomes of other organisms Serves as a basis for chromosome-level genome assemblies Offers a detailed summation of three decades of ZooFish (chromosome painting) Presents high-resolution photos of karyotypes that represent more than 1,000 mammal species Written for geneticists, mammalogists, and biologists, the Atlas of Mammalian Chromosomes offers a step forward for an understanding of species formation, of genome organization, and of DNA script for natural selection.
Author: Wei-Shou Hu
Publisher: Springer Science & Business Media
ISBN: 3642283497
Category : Science
Languages : en
Pages : 305
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Book Description
Transcriptome Analysis, by Frank Stahl, Bernd Hitzmann, Kai Mutz, Daniel Landgrebe, Miriam Lübbecke, Cornelia Kasper, Johanna Walter und Thomas Scheper Transcriptome Data Analysis for Cell Culture Processes, by Marlene Castro-Melchor, Huong Le und Wei-Shou Hu Modeling Metabolic Networks for Mammalian Cell Systems: General Considerations, Modeling Strategies, and Available Tools, by Ziomara P. Gerdtzen Metabolic Flux Analysis in Systems Biology of Mammalian Cells, by Jens Niklas und Elmar Heinzle Advancing Biopharmaceutical Process Development by System-Level Data Analysis and Integration of Omics Data, by Jochen Schaub, Christoph Clemens, Hitto Kaufmann und Torsten W. Schulz Protein Glycosylation and Its Impact on Biotechnology, by Markus Berger, Matthias Kaup und Véronique Blanchard Protein Glycosylation Control in Mammalian Cell Culture: Past Precedents and Contemporary Prospects, by Patrick Hossler Modeling of Intracellular Transport and Compartmentation, by Uwe Jandt und An-Ping Zeng Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective, by L. Botezatu, S. Sievers, L. Gama-Norton, R. Schucht, H. Hauser und D. Wirth.
Author: Pallaval Veera Bramhachari
Publisher: Springer Nature
ISBN: 9811631565
Category : Medical
Languages : en
Pages : 306
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Book Description
The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.
Author: Damir Janigro
Publisher: Springer Science & Business Media
ISBN: 1607612879
Category : Medical
Languages : en
Pages : 237
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Book Description
Denis Noble Nearly a decade after completion of the first draft of the entire Human Genome sequence we are in a better position to assess the nature and the consequences of that heroic achievement, which can be seen as the culmination of the molecular biological revolution of the second half of the twentieth century. The achievement itself was celebrated at the highest levels (President and Prime Minister) on both sides of the Atlantic, and rightly so. DNA sequencing has become sufficiently c- mon now, even to the extent of being used in law courts, that it is easy to forget how technically difficult it was and how cleverly the sequencing teams solved those problems in the exciting race to finish by the turn of the century [1, 2]. The fanfares were misplaced, however, in an important respect. The metaphors used to describe the project and its biological significance gave the impression to the public at large, and to many scientists themselves, that this sequence would reveal the secrets of life. DNA had already been likened to a computer program [3]. The “genetic program” for life was therefore to be found in those sequences: A kind of map that had simply to be unfolded during development. The even more colo- ful “book of life” metaphor gave the promise that reading that book would lead to a veritable outpouring of new cures for diseases, hundreds of new drug targets, and a brave new world of medicine.
Author: Rob DeSalle
Publisher: Birkhäuser
ISBN: 3034881258
Category : Science
Languages : en
Pages : 414
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Book Description
The amount of information that can be obtained by using molecular techniques in evolution, systematics and ecology has increased exponentially over the last ten years. The need for more rapid and efficient methods of data acquisition and analysis is growing accordingly. This manual presents some of the most important techniques for data acquisition developed over the last years. The choice and justification of data analysis techniques is also an important and critical aspect of modern phylogenetic and evolutionary analysis and so a considerable part of this volume addresses this important subject. The book is mainly written for students and researchers from evolutionary biology in search for methods to acquire data, but also from molecular biology who might be looking for information on how data are analyzed in an evolutionary context. To aid the user, information on web-located sites is included wherever possible. Approaches that will push the amount of information which systematics will gather in the
Author: Jean-Nicolas Volff
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318013765
Category : Medical
Languages : en
Pages : 225
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Book Description
The publication of the first draft of the human genome five years ago marked the start of a new era of vertebrate comparative genomics. Genome draft sequences for chimpanzee, mouse, rat, dog, chicken as well as for several fish species are now available for the reconstruction of the evolutionary history of vertebrate genomes over the last 450 million years. This volume of Genome Dynamics presents a timely update on the past, present and future of major vertebrate genome projects. In 16 chapters, renowned specialists provide informative reviews on the current status of mammalian, bird, amphibian and fish genomics. In addition, a chapter on urochordate genomes is included. The reader will also find a useful overview of resources available for each genome as well as a description of the medical and economical perspectives opened by the different projects. This book is recommended reading for biologists interested in genetics, genomics, evolution and zoology.
Author: James R. Brown
Publisher: CRC Press
ISBN: 1420008870
Category : Science
Languages : en
Pages : 409
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Book Description
Through comparative analysis, the genomes of a number of species are providing a deeper understanding of the human genome. This is highly useful in drug research, especially in the treatment of otherwise intractable conditions. Compiling first-hand descriptions of the pioneering achievements of prominent researchers, this text focuses on revolutionary advances in DNA-sequencing technology, new approaches to the organization and analysis of large phylogenetic data sets, new perspectives on evolution, and the development of novel antimicrobial drugs. This seminal volume demonstrates both the means and the fruits of cooperation across a number of fields, and in doing so lays the groundwork for continued progress.
Author: Stephen J. O'Brien
Publisher: John Wiley & Sons
ISBN: 0471779040
Category : Science
Languages : en
Pages : 544
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Book Description
A stunning visual collection of the banded metaphase chromosomekaryotypes from some 850 species of mammals, the Atlas of MammalianChromosomes represents an unabridged compendium of the state ofthis genomic art form. Bringing together information currentlyscattered throughout the cytogenetics literature for scores ofpublished and unpublished species, this atlas features high-qualitykaryotype images for nearly every mammal studied to date, making itthe most comprehensive assemblage of high-resolution chromosomephotographs available--a critically invaluable resource for today'scomparative genomics era. For every available species, the Atlas of Mammalian Chromosomespresents the best karyotype produced, the common and Latin name ofthe species, the published citation, and the contributing authors.Most karyotypes are G-banded, revealing the chromosomal bar codesof homologous segments among related species. Addressing the mandate of the Human Genome Project to annotate thegenomes of other organisms as well, the Atlas of MammalianChromosomes offers a step forward in our understanding of speciesformation, of genome organization, and of DNA script for naturalselection. It is an invaluable resource for geneticists,mammalogists, and biologists interested in comparative genomics,systematics, and chromosome structure.
Author: Jorge Ortega
Publisher: Springer Nature
ISBN: 3030333345
Category : Nature
Languages : en
Pages : 374
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Book Description
This book focuses on the use of molecular tools to study small populations of rare and endangered mammals, and presents case studies that apply an evolutionary framework to address innovative questions in the emerging field of mammalian conservation genomics using a highly diverse set of novel molecular tools. Novel and more precise molecular technologies now allow experts in the field of mammology to interpret data in a more contextual and empirical fashion and to better describe the evolutionary and ecological processes that are responsible for the patterns they observe. The book also demonstrates how recent advances in genetic/genomic technologies have been applied to assess the impact of environmental/anthropogenic changes on the health of small populations of mammals. It examines a range of issues in the field of mammalian conservation genomics, such as the role that the genetic diversity of the immune system plays in disease protection and local adaptation; the use of noninvasive techniques and genomic banks as a resource for monitoring and restoring populations; the structuring of population by physical barriers; and genetic diversity. Further, by integrating research from a variety of areas – including population genetics, molecular ecology, systematics, and evolutionary and conservation biology – it enables readers to gain a deeper understanding of the conservation biology of mammals that are at increasing risk of extinction at local, regional and global scales. As such, it offers a unique resource for a broad readership interested in the conservation biology of mammals and conservation management strategies to better preserve biodiversity.
