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Author: Mones Berman
Publisher: Elsevier
ISBN: 032314764X
Category : Science
Languages : en
Pages : 511
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Book Description
Lipoprotein Kinetics and Modeling contains some of the papers presented at a conference on the analysis and modeling of lipoprotein kinetic data held in Phoenix, Arizona. Contributions from both theorists and experimentalists who attended the conference focus on the developments in the use of mathematical modeling in analyzing the lipoprotein kinetics. The conference highlights the role of kinetic modeling in elucidating the dynamic processes involved in lipoprotein metabolism, the result of improper data analysis that can lead to erroneous physiological interpretations, and the emerging complexities in the lipoprotein system. Organized into six sections comprised of 37 chapters, this book begins with an overview of the theory and applications of kinetic analysis and modeling to lipoproteins. It then discusses the role of kinetic modeling in physiology, the kinetics of apoprotein B in humans, the use of kinetics in investigating the metabolism of very low and intermediate-density lipoproteins, and the models of plasma lipoprotein triglyceride kinetics. It explains the cholesterol kinetics and modeling, the kinetics of high density lipoprotein metabolism in humans, and various techniques for the analysis and modeling of lipoprotein kinetic data such as KABIS (kinetic analysis by interactive simulation) and CONSAM (conversational version of the SAAM modeling program). This book will be of interest to biologists, physiologists, clinical researchers and experts in computer technology and mathematics.
Author: Mones Berman
Publisher: Elsevier
ISBN: 032314764X
Category : Science
Languages : en
Pages : 511
Get Book Here
Book Description
Lipoprotein Kinetics and Modeling contains some of the papers presented at a conference on the analysis and modeling of lipoprotein kinetic data held in Phoenix, Arizona. Contributions from both theorists and experimentalists who attended the conference focus on the developments in the use of mathematical modeling in analyzing the lipoprotein kinetics. The conference highlights the role of kinetic modeling in elucidating the dynamic processes involved in lipoprotein metabolism, the result of improper data analysis that can lead to erroneous physiological interpretations, and the emerging complexities in the lipoprotein system. Organized into six sections comprised of 37 chapters, this book begins with an overview of the theory and applications of kinetic analysis and modeling to lipoproteins. It then discusses the role of kinetic modeling in physiology, the kinetics of apoprotein B in humans, the use of kinetics in investigating the metabolism of very low and intermediate-density lipoproteins, and the models of plasma lipoprotein triglyceride kinetics. It explains the cholesterol kinetics and modeling, the kinetics of high density lipoprotein metabolism in humans, and various techniques for the analysis and modeling of lipoprotein kinetic data such as KABIS (kinetic analysis by interactive simulation) and CONSAM (conversational version of the SAAM modeling program). This book will be of interest to biologists, physiologists, clinical researchers and experts in computer technology and mathematics.
Author: Monnes Berman
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Martin Adiels
Publisher:
ISBN: 9789172915404
Category :
Languages : en
Pages : 116
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Book Description
Author: P. Hugh R. Barrett
Publisher:
ISBN:
Category : Lipoproteins
Languages : en
Pages :
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Book Description
Author: Joan Yvette Letizia
Publisher:
ISBN:
Category : Medical Profession
Languages : en
Pages : 276
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Book Description
Author: Richard Elroy Neubauer
Publisher:
ISBN:
Category :
Languages : en
Pages : 212
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Book Description
Author: Theodore Wai Keong Ng
Publisher:
ISBN:
Category : Apolipoproteins
Languages : en
Pages : 652
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Book Description
[Truncated abstract] Dyslipidaemia in obesity and the metabolic syndrome is typically characterized by elevated plasma concentrations of apolipoprotein (apo) B and chylomicron remnants, and low apoA-I levels. This may account for the increased risk of cardiovascularrelated diseases. Although the precise mechanisms whereby visceral obesity confers the onset of dyslipidaemia have not been fully established, it may relate chiefly to insulin resistance. Insulin resistance leads to increased hepatic secretion of very low density lipoprotein (VLDL) apoB, as well as impaired catabolism of VLDL, intermediate density lipoprotein (IDL), low-density lipoprotein (LDL) and chylomicron remnants, and high density lipoprotein (HDL) apoA-I. This thesis tests the unifying hypothesis that lipoprotein metabolism, in particular apoB, chylomicron remnants and apoA-I, is abnormal in the metabolic syndrome, and that medical intervention can correct for these abnormalities. The primary objectives were to examine firstly, the kinetics of apoB and apoA-I by stable isotope technology and secondly, chylomicron remnant kinetics by using an indirect assessment of a new breath test. Six observational statements and related hypotheses were constructed and derived from the unifying hypothesis that examine the kinetics of lipoprotein metabolism, adipose tissue mass compartments and liver fat accumulation, as well as the impact of plasma adipocytokines in subjects with visceral adiposity and features of the metabolic syndrome. The first four observational statements related to cross-sectional studies of lipoprotein kinetics, adipose tissue mass distribution and liver fat accumulation as well as plasma adipocytokines in both obese and non-obese men. The latter two observational statements related to the effect of statin therapy and dietary weight loss on the improvement of lipoprotein kinetics in obesity. The findings from these studies collectively support the unifying hypothesis. ... In multiple regression analysis, the decrease in RBP-4 was a significant, independent predictor of LDL catabolism, whilst the increase in adiponectin was a significant and independent predictor of HDL catabolism. This is the first study to examine the effects of dietary weight loss on LDL and HDL metabolism and the relationships with adipocytokines in men with the metabolic syndrome. The data support the unifying hypothesis that medical intervention with dietary weight loss could correct the kinetic abnormalities in VLDL, LDL and HDL. The aforementioned studies showed that plasma lipid and lipoprotein abnormalities in visceral obesity are chiefly regulated by the combination of hepatic over-secretion of VLDL particles, and catabolic defects in apoB and chylomicron remnants as well as apoA-I-containing lipoprotein particles. These kinetic defects may also relate to low and high plasma adiponectin and RBP-4 levels, respectively. The data arising from the thesis are consistent with the unifying hypothesis and support the role of dietary intervention and pharmacotherapy as a recommended treatment in correcting the abnormalities in lipoprotein metabolism within the metabolic syndrome.
Author: Claude L. Malmendier
Publisher: Springer Science & Business Media
ISBN: 146845904X
Category : Medical
Languages : en
Pages : 430
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Book Description
The past two decades have seen steady progress in our understanding of the pathogenesis of atherosclerosis. The role of low density lipoprotein (LOL) increase and of LOL receptor deficiency or malfunctions in familial hypercholesterolemia has been largely enlightened by the works of Brown and Goldstein. These authors postulated also that modification of LOL to a form recognized by the scavenger or acetyl-LOL receptor may be required for lipid loading of macrophage-derived foam cells in the lesions. A growing body of evidence suggests that oxidative modification of LOL could enhance its atherogenicity by its implication as a factor in the generation of foam cells. Thus, if the role of LOL in the pathogenesis of hypercholesterolemia was well established a great deal of information appears currently on new approaches such as the mechanisms leading to the accumulation of foam cells, the impact of LOL structural alterations, notably oxidation and the role of gene mutations of apolipoprotein Band/or LOL receptor The opening topic is devoted to these new avenues outlined in the field of hypercholesterolemia. The first part concerns the genetic aspects of atherosclerosis: mainly the genetics of apo 1 ipoprote ins , their transcriptional regulation, the amino acid mutations of the apo B gene and of the LOL receptor gene, the structural domains and the acylation sites of apoprotein B.
Author: K. N. Siva Subramanian
Publisher: CRC Press
ISBN: 1000714314
Category : Medical
Languages : en
Pages : 420
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Book Description
Kinetic models are becoming standard tools in the research of biological systems. They are used to represent hypotheses, analyze data, and design experiments to maximize the information obtained from a study. Kinetic Models of Trace Element and Mineral Metabolism During Development describes models for calcium, chromium, copper, iron, iodide, lead, mercury, selenium, zinc, and others in health and disease.
