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Author: Kris Bogaerts
Publisher: CRC Press
ISBN: 1351643053
Category : Mathematics
Languages : en
Pages : 537
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Book Description
Survival Analysis with Interval-Censored Data: A Practical Approach with Examples in R, SAS, and BUGS provides the reader with a practical introduction into the analysis of interval-censored survival times. Although many theoretical developments have appeared in the last fifty years, interval censoring is often ignored in practice. Many are unaware of the impact of inappropriately dealing with interval censoring. In addition, the necessary software is at times difficult to trace. This book fills in the gap between theory and practice. Features: -Provides an overview of frequentist as well as Bayesian methods. -Include a focus on practical aspects and applications. -Extensively illustrates the methods with examples using R, SAS, and BUGS. Full programs are available on a supplementary website. The authors: Kris Bogaerts is project manager at I-BioStat, KU Leuven. He received his PhD in science (statistics) at KU Leuven on the analysis of interval-censored data. He has gained expertise in a great variety of statistical topics with a focus on the design and analysis of clinical trials. Arnošt Komárek is associate professor of statistics at Charles University, Prague. His subject area of expertise covers mainly survival analysis with the emphasis on interval-censored data and classification based on longitudinal data. He is past chair of the Statistical Modelling Society and editor of Statistical Modelling: An International Journal. Emmanuel Lesaffre is professor of biostatistics at I-BioStat, KU Leuven. His research interests include Bayesian methods, longitudinal data analysis, statistical modelling, analysis of dental data, interval-censored data, misclassification issues, and clinical trials. He is the founding chair of the Statistical Modelling Society, past-president of the International Society for Clinical Biostatistics, and fellow of ISI and ASA.
Author: Kris Bogaerts
Publisher: CRC Press
ISBN: 1351643053
Category : Mathematics
Languages : en
Pages : 537
Get Book Here
Book Description
Survival Analysis with Interval-Censored Data: A Practical Approach with Examples in R, SAS, and BUGS provides the reader with a practical introduction into the analysis of interval-censored survival times. Although many theoretical developments have appeared in the last fifty years, interval censoring is often ignored in practice. Many are unaware of the impact of inappropriately dealing with interval censoring. In addition, the necessary software is at times difficult to trace. This book fills in the gap between theory and practice. Features: -Provides an overview of frequentist as well as Bayesian methods. -Include a focus on practical aspects and applications. -Extensively illustrates the methods with examples using R, SAS, and BUGS. Full programs are available on a supplementary website. The authors: Kris Bogaerts is project manager at I-BioStat, KU Leuven. He received his PhD in science (statistics) at KU Leuven on the analysis of interval-censored data. He has gained expertise in a great variety of statistical topics with a focus on the design and analysis of clinical trials. Arnošt Komárek is associate professor of statistics at Charles University, Prague. His subject area of expertise covers mainly survival analysis with the emphasis on interval-censored data and classification based on longitudinal data. He is past chair of the Statistical Modelling Society and editor of Statistical Modelling: An International Journal. Emmanuel Lesaffre is professor of biostatistics at I-BioStat, KU Leuven. His research interests include Bayesian methods, longitudinal data analysis, statistical modelling, analysis of dental data, interval-censored data, misclassification issues, and clinical trials. He is the founding chair of the Statistical Modelling Society, past-president of the International Society for Clinical Biostatistics, and fellow of ISI and ASA.
Author: Stef van Buuren
Publisher: CRC Press
ISBN: 0429960352
Category : Mathematics
Languages : en
Pages : 444
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Book Description
Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between these replacements reflects our ignorance of the true (but missing) value. Each of the completed data set is then analyzed by standard methods, and the results are pooled to obtain unbiased estimates with correct confidence intervals. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing-data problem. This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the MICE package as developed by the author. This new edition incorporates the recent developments in this fast-moving field. This class-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by verbal statements that explain the formula in accessible terms. The book sharpens the reader’s intuition on how to think about missing data, and provides all the tools needed to execute a well-grounded quantitative analysis in the presence of missing data.
Author: Jianguo Sun
Publisher: Springer Nature
ISBN: 3031123662
Category : Mathematics
Languages : en
Pages : 322
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Book Description
This book primarily aims to discuss emerging topics in statistical methods and to booster research, education, and training to advance statistical modeling on interval-censored survival data. Commonly collected from public health and biomedical research, among other sources, interval-censored survival data can easily be mistaken for typical right-censored survival data, which can result in erroneous statistical inference due to the complexity of this type of data. The book invites a group of internationally leading researchers to systematically discuss and explore the historical development of the associated methods and their computational implementations, as well as emerging topics related to interval-censored data. It covers a variety of topics, including univariate interval-censored data, multivariate interval-censored data, clustered interval-censored data, competing risk interval-censored data, data with interval-censored covariates, interval-censored data from electric medical records, and misclassified interval-censored data. Researchers, students, and practitioners can directly make use of the state-of-the-art methods covered in the book to tackle their problems in research, education, training and consultation.
Author: Clifford Isaac Anderson-Bergman
Publisher:
ISBN: 9781303810138
Category :
Languages : en
Pages : 213
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Book Description
Interval censoring occurs when event times are known to have occurred within an interval, rather than observing the exact time of event. This includes observations that are right censored, left censored and contained in intervals such that the left side is greater than the origin and the right side is finite (i.e. neither right censored or left censored). For interval censored data, the most common survival estimator used is the non-parametric maximum likelihood estimator (NPMLE), a generalization of the Kaplan-Meier curve which does not require any uncensored event times. The popularity of this estimator is due in part to the fact that assessing model fit for interval censored data can be very difficult. However, the extreme flexibility of the estimator comes at the cost of high variance, often providing an n^(1/3) convergence rate rather than the more typical n^(1/2). In a compromise between a highly constrained parametric estimator and the overly flexible NPMLE, we apply the popular log-concave density constraint to the NPMLE. By constraining a non-parametric estimator to have a log-concave density, an inves- tigator can improve the performance without needing to select a parametric family or smoothing parameter. We describe a fast algorithm we have developed for finding the log-concave NPMLE for interval censored data. We demonstrate that using the constraint significantly reduces the variance of the survival estimates in comparison to the unconstrained NPMLE via simulations. Next, we present three inference methods for our new estimator. This includes a goodness of fit test, two methods of confidence interval construction and a Cox PH model which incorporates a baseline log-concave distribution. We evaluate the power of the goodness of fit test and compare the other inference methods with the unconstrained counterparts via simulation. We apply these methods to a study on the effects of different environments on the rates of lung cancer among mice and another study investigating age at menopause. While our work demonstrates that the application of the shape constraints can be very helpful in the context of interval censored data, in some situations the log- concave constraint may not allow for as heavy tailed distributions as the investigator would like. To address this, we propose a new, more flexible "inverse convex" shape constraint, examine its behavior via simulation and show that it provides a better fit than the log-concave estimator when applied to real income data, which is well known to be heavy tailed. We are very optimistic about applying this new estimator to censored data, although we have yet to implement an algorithm to do so. We end this work with an algorithm for finding the (unconstrained) bivariate NPMLE for interval censored data. The bivariate NPMLE is used when each subject has two censored outcomes and the investigator is interested in modeling the relation between the two outcomes. Quickly finding the NPMLE has proven to be a challenging computational problem, as the number of parameters to consider is of order O(n^2). We present an efficient EM algorithm to find the bivariate NPMLE. We note that this is not related to shape constrained estimation.
Author: Jianguo Sun
Publisher: Springer
ISBN: 0387371192
Category : Mathematics
Languages : en
Pages : 310
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Book Description
This book collects and unifies statistical models and methods that have been proposed for analyzing interval-censored failure time data. It provides the first comprehensive coverage of the topic of interval-censored data and complements the books on right-censored data. The focus of the book is on nonparametric and semiparametric inferences, but it also describes parametric and imputation approaches. This book provides an up-to-date reference for people who are conducting research on the analysis of interval-censored failure time data as well as for those who need to analyze interval-censored data to answer substantive questions.
Author: Jonathan D. Mahnken
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 236
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Book Description
Of the large clinical trials evaluating screening mammography efficacy, none included women ages 75 and older. Recommendations on an upper age limit at which to discontinue screening are based on indirect evidence and are not consistent. Screening mammography is evaluated using observational data from the SEER-Medicare linked database. Measuring the benefit of screening mammography is difficult due to the impact of lead-time bias, length bias and over-detection. The underlying conceptual model divides the disease into two stages: pre-clinical (T0) and symptomatic (T1) breast cancer. Treating the time in these phases as a pair of dependent bivariate observations, (t0,t1), estimates are derived to describe the distribution of this random vector. To quantify the effect of screening mammography, statistical inference is made about the mammography parameters that correspond to the marginal distribution of the symptomatic phase duration (T1). This shows the hazard ratio of death from breast cancer comparing women with screen-detected tumors to those detected at their symptom onset is 0.36 (0.30, 0.42), indicating a benefit among the screen-detected cases.
Author: Harry Joe
Publisher: CRC Press
ISBN: 9780412073311
Category : Mathematics
Languages : en
Pages : 422
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Book Description
This book on multivariate models, statistical inference, and data analysis contains deep coverage of multivariate non-normal distributions for modeling of binary, count, ordinal, and extreme value response data. It is virtually self-contained, and includes many exercises and unsolved problems.
Author: Ding-Geng (Din) Chen
Publisher: CRC Press
ISBN: 1466504285
Category : Mathematics
Languages : en
Pages : 426
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Book Description
Interval-Censored Time-to-Event Data: Methods and Applications collects the most recent techniques, models, and computational tools for interval-censored time-to-event data. Top biostatisticians from academia, biopharmaceutical industries, and government agencies discuss how these advances are impacting clinical trials and biomedical research.Divid
Author: Mara Tableman
Publisher: CRC Press
ISBN: 0203501411
Category : Mathematics
Languages : en
Pages : 277
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Book Description
Survival Analysis Using S: Analysis of Time-to-Event Data is designed as a text for a one-semester or one-quarter course in survival analysis for upper-level or graduate students in statistics, biostatistics, and epidemiology. Prerequisites are a standard pre-calculus first course in probability and statistics, and a course in applied linear regression models. No prior knowledge of S or R is assumed. A wide choice of exercises is included, some intended for more advanced students with a first course in mathematical statistics. The authors emphasize parametric log-linear models, while also detailing nonparametric procedures along with model building and data diagnostics. Medical and public health researchers will find the discussion of cut point analysis with bootstrap validation, competing risks and the cumulative incidence estimator, and the analysis of left-truncated and right-censored data invaluable. The bootstrap procedure checks robustness of cut point analysis and determines cut point(s). In a chapter written by Stephen Portnoy, censored regression quantiles - a new nonparametric regression methodology (2003) - is developed to identify important forms of population heterogeneity and to detect departures from traditional Cox models. By generalizing the Kaplan-Meier estimator to regression models for conditional quantiles, this methods provides a valuable complement to traditional Cox proportional hazards approaches.
Author: Marius Hofert
Publisher: Springer
ISBN: 3319896350
Category : Business & Economics
Languages : en
Pages : 274
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Book Description
This book introduces the main theoretical findings related to copulas and shows how statistical modeling of multivariate continuous distributions using copulas can be carried out in the R statistical environment with the package copula (among others). Copulas are multivariate distribution functions with standard uniform univariate margins. They are increasingly applied to modeling dependence among random variables in fields such as risk management, actuarial science, insurance, finance, engineering, hydrology, climatology, and meteorology, to name a few. In the spirit of the Use R! series, each chapter combines key theoretical definitions or results with illustrations in R. Aimed at statisticians, actuaries, risk managers, engineers and environmental scientists wanting to learn about the theory and practice of copula modeling using R without an overwhelming amount of mathematics, the book can also be used for teaching a course on copula modeling.
