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Author: Robert D. Burgoyne
Publisher: Ashgate Publishing
ISBN: 9781855781016
Category : Cell interaction
Languages : en
Pages : 267
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Book Description
The intracellular signalling pathways that control cell function have been and still are, one of the most intensively studied aspects of biology. The aim of this work is to provide full reproductions of a set of key papers which have been chosen as landmark papers in the various aspects of intracellular signalling. The papers are accompanied by commentaries that describe why they are significant, how the work came about and summarize the advances that have been made up to the present time as a consequence of the original paper. The commentaries should also serve as reviews of aspects of cell regulation and may be read on their own.
Author: Robert D. Burgoyne
Publisher: Ashgate Publishing
ISBN: 9781855781016
Category : Cell interaction
Languages : en
Pages : 267
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Book Description
The intracellular signalling pathways that control cell function have been and still are, one of the most intensively studied aspects of biology. The aim of this work is to provide full reproductions of a set of key papers which have been chosen as landmark papers in the various aspects of intracellular signalling. The papers are accompanied by commentaries that describe why they are significant, how the work came about and summarize the advances that have been made up to the present time as a consequence of the original paper. The commentaries should also serve as reviews of aspects of cell regulation and may be read on their own.
Author:
Publisher: Academic Press
ISBN: 0128155620
Category : Medical
Languages : en
Pages : 462
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Book Description
Intracellular Signalling Proteins, Volume 116, presents an overview of the current developments in mechanisms of intracellular signaling and involvement of these mechanisms in the development of a number of disorders and diseases. Opportunities for targeting the intracellular signaling cascades for benefiting patients are also discussed, along with chapters that focus on Voices from the Dead: The Complex Language of Dead Cells, Nucleobindins and Encoded Peptides: From Cell Signalling to Physiology, Estrogen Receptor Signaling Mechanisms, Intracellular Signaling of the AMP-Activating Protein Kinase, the Relationship between Mitofusin 2 and Cancer, Molecular Signaling in Bone Cells: Regulation Cell Differentiation and Survival, and more. Describes advances in the discovery and application of therapeutics that target intracellular signaling mechanisms Targeted to a very wide audience of specialists, researchers and students Contains timely chapters written by well-renowned authorities in their field Includes a number of high quality illustrations, figures and tables
Author: John T. Hancock
Publisher: Oxford University Press
ISBN: 019965848X
Category : Cell interaction
Languages : en
Pages : 451
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Book Description
'Cell Signalling' presents a carefully structured introduction to this subject, introducing those conserved features which underlie many different extra-and intracellular signalling systems.
Author: John Hancock
Publisher: Oxford University Press, USA
ISBN: 0199232105
Category : Education
Languages : en
Pages : 364
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Book Description
Signalling within and between cells is an essential part of many biological processes, from the development of the body to the activity of our immune system. Cell Signalling, Third Edition, presents a carefully structured introduction to this intricate subject, introducing those conserved features that underlie many different extra- and intracellular signalling systems. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms before examining how these components come together to create signalling pathways, which are so crucial to the survival of many living organisms. The text is enhanced by two-color artwork and 3-D protein models. A Companion Website provides resources for students and instructors.
Author: Paul Farquhar-Smith
Publisher: Oxford University Press
ISBN: 0198834357
Category : Medical
Languages : en
Pages : 337
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Book Description
Pain Medicine, a relatively new specialty, has proven increasingly relevant to medical practitioners in every field. The specialism of pain has emerged over the past 50 years, largely due to the persistence of experts and new medical evidence that points to its necessity. Today, it is a distinct and integral part of global medical practice. Landmark Papers in Pain offers a comprehensive inventory of over 80 key studies in pain medicine from the last 100 years. Each paper is accompanied by a concise commentary on the significance of the original findings written by an expert in pain. The reviews discuss how the paper influenced the development of the speciality, and how the findings have advanced our global comprehension of pain. Together, the selected papers and reviews chart the growth of an embryonic field into the modern speciality of pain medicine. Complied by leading specialists in the field, the papers included in this book are significant for any student, researcher, clinical practitioner, or medical historian interested in pain medicine. Organised into eight distinct topics and cross-referenced by topics and author of original paper, the book is comprehensive in its coverage and easy to use. A review of the contemporary and historical research that shaped the speciality of pain, Landmark Papers in Pain is essential reading for all medical practitioners with an interest in pain medicine.
Author: John Feehally
Publisher: Oxford University Press
ISBN: 0199699259
Category : Medical
Languages : en
Pages : 465
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Book Description
This book selects the most important scientific papers related to kidney disease and comments on their significance within the wider field. Fascinating reading for both nephrologists and medical historians, no doubt giving rise to further debate over the origins and progress of nephrology.
Author: Nava Segev
Publisher: Springer Science & Business Media
ISBN: 038793877X
Category : Science
Languages : en
Pages : 459
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Book Description
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Author: Pascal Leclair
Publisher: CRC Press
ISBN: 1000897575
Category : Science
Languages : en
Pages : 253
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Book Description
Proteins are the workhorses of cells, performing most of the important functions which allow cells to use nutrients and grow, communicate among each other, and importantly, die if aberrant behavior is detected. How were proteins discovered? What is their role in cells? How do dysfunctional proteins give rise to cancers? Landmark Experiments in Protein Science explores the manner in which the inner workings of cells were elucidated, with a special emphasis on the role of proteins. Experiments are discussed in a manner as to understand what questions were being asked that prompted the experiments and what technical challenges were faced in the process; and results are presented and discussed using primary data and graphs. Key Features Describes landmark experiments in cell biology and biochemistry. Discusses the "How" and "Why" of historically important experiments. Includes primary, original data and graphs. Emphasizes biological techniques, that help understand how many of the experiments performed were possible. Documents, chronologically, how each result fed into the next experiments.
Author: Biochemical Society (Great Britain)
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages : 524
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Book Description
Author: Martin Beckerman
Publisher: Springer Science & Business Media
ISBN: 038798173X
Category : Science
Languages : en
Pages : 477
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Book Description
In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.
