Kv7 Channels: Structure, Physiology and Pharmacology PDF Download
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Author: Thomas Andrew Jepps
Publisher: Frontiers Media SA
ISBN: 2889669149
Category : Science
Languages : en
Pages : 239
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Book Description
This Research Topic was in partnership with CAP Partner for the International Kv7 Channels Symposium held in Naples, Italy on September 2019.
Author: Thomas Andrew Jepps
Publisher: Frontiers Media SA
ISBN: 2889669149
Category : Science
Languages : en
Pages : 239
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Book Description
This Research Topic was in partnership with CAP Partner for the International Kv7 Channels Symposium held in Naples, Italy on September 2019.
Author: Nikita Gamper
Publisher: Springer Nature
ISBN: 3030840522
Category : Medical
Languages : en
Pages : 546
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Book Description
The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.
Author: Jeffrey Noebels
Publisher: OUP USA
ISBN: 0199746540
Category : Medical
Languages : en
Pages : 1258
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Book Description
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author: Richard W. Tsien
Publisher:
ISBN:
Category : Calcium
Languages : en
Pages : 420
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Book Description
Author: Alain Malafosse
Publisher: John Libbey Eurotext
ISBN: 9780861964369
Category : Medical
Languages : en
Pages : 568
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Book Description
Idiopathic generalised epilepsies are characterised by strong genetic factors and multiple clinical phenotypes; animal models of untreated epilepsies are relevant to some of the clinical syndromes found in humans. This volume is the first to confront human clinical, animal (experimental) as well as basic and applied genetic data. Main section headings: Current approaches; Familial neonatal and infantile convulsions; Absence seizures and absence epilepsy; Juvenile myoclonic epilepsy and related syndromes; Photosensitivity; Pathophysiology of convulsive seizures; Fundamental and therapeutic aspects.
Author: James N. C. Kew
Publisher:
ISBN: 0199296758
Category : Medical
Languages : en
Pages : 586
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Book Description
Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.
Author: Peter C. Ruben
Publisher: Springer Science & Business Media
ISBN: 3642415881
Category : Medical
Languages : en
Pages : 328
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Book Description
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Author: Simone Furini
Publisher: Frontiers Media SA
ISBN: 2832509541
Category : Science
Languages : en
Pages : 142
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Book Description
Author: Bernat Soria
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 498
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Book Description
The improved understanding of ion channel structure, achieved through the use of molecular biology techniques, has opened the way for the development of new drugs targeted at specific types of ion channels. This book provides a comprehensive, single-volume overview of the effects of different drugs and toxins on ionic channels. The first part of the book deals with the development of ion channels, while subsequent chapters detail the electrophysiological properties and pharmacology of eight different types of ion channels, including intracellular, cyclic nucleotide-gated, and receptor operated channels. Drug effects in various cell types, along with the potential use of channels in therapeutics, are discussed for each channel type. Comprehensive and up-to-date, Ion Channel Pharmacology is an essential reference for every investigator in this fast-growing area of research.
Author: Bernd Nilius
Publisher: Springer
ISBN: 3319314920
Category : Medical
Languages : en
Pages : 132
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Book Description
Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
