Author: Rolando Guidelli
Publisher: John Wiley & Sons
ISBN: 1119271053
Category : Science
Languages : en
Pages : 356
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Book Description
Invaluable to biochemists, biophysicists, and pharmacological scientists; this book provides insights into the essential principles required to understand why and how electrochemical and electrophysiological tools are fundamental in elucidating the mode of ion transport across biomembranes. • Describes the essential electrochemical basics required to understand why and how electrochemical and electrophysiological tools are fundamental in elucidating the mode of ion transport across biomembranes • Requires only basic physical chemistry and mathematics to be understood, without intermediate stumbling blocks that would discourage the reader from proceeding further • Develops contents in a step-by-step approach that encourages students and researchers to read from beginning to end
Author: R Guidelli
Publisher: Springer Science & Business Media
ISBN: 940112566X
Category : Science
Languages : en
Pages : 604
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Book Description
Electrified interfaces span from metaVsemiconductor and metaVelectrolyte interfaces to disperse systems and biological membranes, and are notably important in so many physical, chemical and biological systems that their study has been tackled by researchers with different scientific backgrounds using different methodological approaches. The various electrified interfaces have several common features. The equilibrium distribution of positive and negative ions in an electrolytic solution is governed by the same Poisson-Boltzmann equation independent of whether the solution comes into contact with a metal, a colloidal particle or a biomembrane, and the same is true for the equilibrium distribution of free electrons and holes of a semiconductor in contact with a different conducting phase. Evaluation of electric potential differences across biomembranes is based on the same identity of electrochemical potentials which holds for a glass electrode and which yields the Nernst equation when applied to a metal/solution interface. The theory of thermally activated electron tunneling, which was developed by Marcus, Levich, Dogonadze and others to account for electron transfer across metaVelectrolyte interfaces, is also applied to light induced charge separation and proton translocation reactions across intercellular membranes. From an experimental viewpoint, the same electrochemical and in situ spectroscopic techniques can equally well be employed for the study of apparently quite different electrified interfaces.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Peter C. Ruben
Publisher: Springer Science & Business Media
ISBN: 3642415881
Category : Medical
Languages : en
Pages : 328
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Book Description
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Author: ROLANDO. GUIDELLI
Publisher:
ISBN: 9781527599703
Category :
Languages : en
Pages : 0
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Book Description
This volume provides a unified treatment that interprets the salient features of the experimental relationship between the structure and function of ion channels. This treatment encompasses both the voltage-gated ion channels in charge of excitable membranes and the smaller antimicrobial peptide ion channels. The book requires only an understanding of basic physical chemistry and mathematics, and will be accessible to graduate students, research workers, and teachers in biophysics, bioelectrochemistry, biology, biochemistry, pharmacology, physiology, bioanalytical chemistry, and related disciplines. It provides insights into the basic principles required to understand why and how a combination of electrophysiological and electrochemical concepts and tools is essential in clarifying the mode of ion transport across biomembranes through ion channels. In this respect, this book bridges the gap arising from the difficulties encountered by biologists in understanding concepts of electrochemistry, and vice-versa, to the benefit of all life scientists.
Author: Mohammad Ashrafuzzaman
Publisher: CRC Press
ISBN: 100045164X
Category : Science
Languages : en
Pages : 459
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Book Description
This book provides a comprehensive review of the biophysics and nanotechnology of ion channels. It details the biological and physiological entities of ion channels in cells and addresses various physical perspectives of ion channel structures and functions. Naturally inbuilt and artificial applicable nanotechnologies of ion channels are modelled and explored. It discusses various methods that can be utilized toward understanding ion channel-based cellular diseases. Physical, biochemical, biomedical, and bioinformatics techniques are taken into consideration to enable the development of strategies to address therapeutic drug discovery and delivery. This book will be of interest to advanced undergraduate and graduate students in biophysics and related biomedical sciences in addition to researchers in the field and industry. Features: Provides a stimulating introduction to the structures and functions of ion channels of biological cell membranes and discusses the biophysics of ion channels in condensed matter state and physiological condition Addresses natural processes and nanotechnology opportunities for their purposeful manipulation Lays the groundwork for vitally important medical advances Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate about investigating biological and biochemical processes utilizing the principles and techniques of physics. He is an associate professor at King Saud University’s Biochemistry Department of College of Science, Riyadh, Saudi Arabia, the co-founder of MDT Canada Inc., and the founder of Child Life Development Institute, Edmonton, Canada. He also authored Nanoscale Biophysics of the Cell and Membrane Biophysics.
Author: François Chaumont
Publisher: Springer
ISBN: 3319493957
Category : Science
Languages : en
Pages : 354
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Book Description
Aquaporins are channel proteins that facilitate the diffusion of water and small uncharged solutes across cellular membranes. Plant aquaporins form a large family of highly divergent proteins that are involved in many different physiological processes. This book will summarize the recent advances regarding plant aquaporins, their phylogeny, structure, substrate specificity, mechanisms of regulation and roles in various important physiological processes related to the control of water flow and small solute distribution at the cell, tissue and plant level in an ever-changing environment.
Author: Fatima Shad Kaneez
Publisher: BoD – Books on Demand
ISBN: 1789842271
Category : Science
Languages : en
Pages : 204
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Book Description
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Author: Wilfred D. Stein
Publisher: Elsevier
ISBN: 0124165834
Category : Science
Languages : en
Pages : 423
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Book Description
An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in health and disease are also considered. - Provides an introduction to the properties of transport proteins: channels, carriers, and pumps - Presents up-to-date information on the structure of transport proteins and on their function and regulation - Includes introductions to transport kinetics and to the cloning of genes that code transport proteins - Furnishes a link between the experimental basis of the subject and theoretical model building
Author: Stephen H White
Publisher: Garland Science
ISBN: 1000508536
Category : Medical
Languages : en
Pages : 565
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Book Description
The central themes of Cell Boundaries concern the structural and organizational principles underlying cell membranes, and how these principles enable function. By building a biological and biophysical foundation for understanding the organization of lipids in bilayers and the folding, assembly, stability, and function of membrane proteins, the book aims to broaden the knowledge of bioscience students to include the basic physics and physical chemistry that inform us about membranes. In doing so, it is hoped that physics students will find familiar territory that will lead them to an interest in biology. Our progress toward understanding membranes and membrane proteins depends strongly upon the concerted use of both biology and physics. It is important for students to know not only what we know, but how we have come to know it, so Cell Boundaries endeavours to bring out the history behind the central discoveries, especially in the early chapters, where the foundation is laid for later chapters. Science is far more interesting if, as students, we can appreciate and share in the adventures—and misadventures—of discovering new scientific knowledge. Cell Boundaries was written with advanced undergraduates and beginning graduate students in the biological and physical sciences in mind, though this textbook will likely have appeal to researchers and other academics as well. Highlights the history of important central discoveries Early chapters lay the foundation for later chapters to build on, so knowledge is amassed High-quality line diagrams illustrate key concepts and illuminate molecular mechanisms Box features and spreads expand on topics in main text, including histories of discoveries, special techniques, and applications
