Investigation of the Calcium Binding Protein (calbindin-D28k) Gene PDF Download
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Author: Anthony M. Iacopino
Publisher:
ISBN:
Category :
Languages : en
Pages : 294
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Book Description
Author: Anthony M. Iacopino
Publisher:
ISBN:
Category :
Languages : en
Pages : 294
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Book Description
Author: Anthony Norman
Publisher: Elsevier
ISBN: 0323141420
Category : Medical
Languages : en
Pages : 650
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Book Description
Calcium-Binding Proteins in Health and Disease includes the papers prepared by the invited speakers as well as many of the free communications. The contributions are grouped according to their general subject matter, based on the classification made by the authors, e.g., Extracellular Metabolism: Calcium Homeostasis; Low-Affinity Calcium-Binding Proteins. There can be little doubt that calcium-binding proteins is a field of scientific endeavor which will continue to produce results of great interest to modern biology. This book is divided into eight sections, the first of which, tackle extracellular calcium metabolism or calcium homeostasis. The next sections focus on topics such as low-affinity calcium-binding proteins; calcium and membranes, channels and transport (pumps); the role of calcium in complex metabolic processes; and gene structure of calcium-binding proteins and their expression. Other chapters cover physical studies on calcium-binding proteins, including X-ray, crystallography, and NMR; structure-function relationships of calcium-binding proteins and their targets; and calcium-binding proteins in health and disease. This book will be of interest to practitioners in the fields of biology and medicine.
Author: Eugene Permyakov
Publisher: John Wiley & Sons
ISBN: 1118099540
Category : Science
Languages : en
Pages : 456
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Book Description
Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography. The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins. It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.
Author: Valerie Lynn Leathers
Publisher:
ISBN:
Category : Calcium in the body
Languages : en
Pages : 556
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Book Description
Author: R. Pochet
Publisher: Springer Science & Business Media
ISBN: 1468457543
Category : Science
Languages : en
Pages : 212
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Book Description
Proceedings of the First European Symposium held in Brussels, Belgium, April 20--22, 1989
Author: Felix Bronner
Publisher: CRC Press
ISBN: 9780849301889
Category : Medical
Languages : en
Pages : 182
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Book Description
Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine presents thinking and front-line research addressing calcium and phosphate homeostasis and related clinical problems. Major topics include calcium and phosphate transport in the mammalian body and some of its defects; several aspects of hormonal control of calcium and phosphorus metabolism, including PTH-related peptide; and basic and clinical aspects of bone and bone diseases. Other topics include calcium entry and extrusion mechanisms, secondary osteoporosis, how bone cells translocate phosphate needed to bone mineral, and the culture of renal and intestinal cells capable of transporting calcium in vitro. The book also features two prize-winning contributions; one deals with the characterization of a major calcium transport protein, calbindin D-9K, while the other discusses how the osteoclast, the bone-resorbing cell, is feedback-regulated. Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine provides plenty of useful information for basic and clinical scientists alike, including biochemists, physiologists, cell biologists, pharmacologists, internists, orthopedic surgeons, dentists, and pathologists.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
The studies described here involve the structural and functional characterization of two proteins, calbindin-D28k and ComAC. Calbindin-D28k is a calcium binding protein that plays a unique role in eukaryotic cells, acting as both a calcium buffer and sensor. Upon binding calcium, calbindin-D28k transitions from an ordered apo- state into a disordered state as calcium is bound. Once fully loaded with four calcium ions it again takes on an ordered state. The high resolution NMR solution structure of holo- calbindin-D28k has been solved. The structure of the apo- calbindin-D28k, however, remains to be solved. In the absence of a high resolution structure of apo- calbindin-D28k it has not been possible to compare the three-dimensional structure of the two states, making it impossible to analyze how this change affects the function of calbindin-D28k. This study uses differential surface modification analyzed by mass spectrometry to probe the tertiary structural changes that occur upon calcium binding. This comparison provides the first look at the conformational change of calbindin-D28k upon calcium binding. In the second study, the structure and function of the C-terminal DNA binding domain of ComA (ComAC) from Bacillus subtilis was investigated. ComA is a response regulator protein involved in the two-component signal transduction system regulating the development of genetic competence. The protein can be divided into two distinct domains, an N-terminal regulatory domain and a C-terminal effector domain. The C-terminal domain, ComAC, is a DNA binding domain responsible for binding to target operons, including the srfA operon. The transcriptional activation of the srfA operon ultimately controls the expression of the genes responsible for expressing the protein machinery that bind to and take up exogenous DNA. This research determined the high resolution solution structure of ComAC using NMR. This structure was then used in conjunction with SPR, NMR DNA titration studie.
Author: Constance Hammond
Publisher: Elsevier
ISBN: 0323986137
Category : Psychology
Languages : en
Pages : 602
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Book Description
Cellular and Molecular Neurophysiology, Fifth Edition is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in graduate-level courses on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field. The new edition contains new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction, and a section containing exercises for further learning. This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. Authoritative foundational coverage of basic cellular and molecular neurophysiology Includes new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction Provides fifteen appendices that describe how neurobiological techniques are interspersed in the text Presents enhanced coverage of new methodologies and experimental techniques
Author: Juergen K Mai
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 284
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Book Description
Accompanying DVD-ROM contains ... "the atlas in electronic format, but also a 3-D visualization software that allows easy browsing of the images, and a feature to allow direct retrieval of brain areas using coordinates obtained in magnetic resonance imaging."--P. [4] of cover.
Author: Robert T. Gerlai
Publisher: Academic Press
ISBN: 0128041161
Category : Mathematics
Languages : en
Pages : 710
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Book Description
Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts
