Introduzione alla diagnostica per immagini in ortopedia e traumatologia. Con CD-ROM PDF Download
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Author: Nicola Baldini
Publisher:
ISBN: 9788849124583
Category : Medical
Languages : it
Pages : 67
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Book Description
Author: Nicola Baldini
Publisher:
ISBN: 9788849124583
Category : Medical
Languages : it
Pages : 67
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Book Description
Author: Federico Grassi
Publisher: Elsevier srl
ISBN: 9788821429187
Category : Medical
Languages : it
Pages : 388
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Book Description
Author: Ygal Haupt
Publisher: Frontiers Media SA
ISBN: 2889199614
Category : Medicine (General)
Languages : en
Pages : 99
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Book Description
TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation.
Author: Paolo Capodaglio
Publisher: Springer Science & Business Media
ISBN: 3642359728
Category : Medical
Languages : en
Pages : 307
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Book Description
Obesity is currently regarded as one of the major health challenges of the developed world. Excess body weight is an important risk factor for morbidity and mortality from cardiovascular diseases, diabetes, cancer, musculoskeletal disorders and even psychiatric problems and is estimated to cause nearly 3 million deaths per year worldwide. Obesity is not necessarily associated with comorbidities: there are indeed metabolically healthy obese individuals. Thus, we need to consider individuals presenting simple with obesity separately from those at risk of developing or who have already developed complex clinical states potentially leading to disability. Comorbidities can tip the balance of independence in patients who already have functional limitations mainly due to the excess of mass itself or who develop conditions such as diabetes, cardiovascular conditions, non-alcoholic fatty liver disease, where an abnormal metabolism of adipose tissue prevails. Morbid obesity with comorbidities leading to disability represents a real social and economic burden for National Health Systems worldwide. The presence of multiple and associated comorbidities often represents an obstacle to being admitted to hospitals for the treatment of metabolic diseases. On the other hand, clinical units with optimal standards for the treatment of pathological conditions in normal-weight patients are often structurally and technologically inadequate for the care of patients with extreme obesity. The aim of this book is to focus on the pathophysiological and rehabilitative aspects of disabling obesity, highlighting multidisciplinary rehabilitation interventions as key to counteracting the disabling aspects of complicated obesity.
Author: Wilma Bucci
Publisher: Guilford Press
ISBN: 9781572302136
Category : Psychology
Languages : en
Pages : 388
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Book Description
Although psychoanalytic concepts underlie most forms of psychotherapy practiced today, the basic Freudian theory of mind the metapsychology does not mesh with current scientific views in psychology and related fields. As a result, despite its many strengths, psychoanalysis has been relegated to the periphery by clinicians and researchers alike. Filling a significant void, this book from cognitive scientist and psychoanalytic researcher Wilma Bucci proposes a new model of psychological organization that integrates psychoanalytic theory with the investigation of mental processes. Solidly rooted in current cognitive science, multiple code theory recognizes the focus on meanings and motives that is intrinsic to psychoanalytic clinical work. The theory points to parallel functions underlying free association and dreams, as well as conceptual development in children and creative work in sciences and the arts, and provides a strong foundation for empirical research on the psychoanalytic treatment process.
Author: Zygmunt Bauman
Publisher: John Wiley & Sons
ISBN: 1509515356
Category : Social Science
Languages : en
Pages : 133
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Book Description
We have long since lost our faith in the idea that human beings could achieve human happiness in some future ideal state—a state that Thomas More, writing five centuries ago, tied to a topos, a fixed place, a land, an island, a sovereign state under a wise and benevolent ruler. But while we have lost our faith in utopias of all hues, the human aspiration that made this vision so compelling has not died. Instead it is re-emerging today as a vision focused not on the future but on the past, not on a future-to-be-created but on an abandoned and undead past that we could call retrotopia. The emergence of retrotopia is interwoven with the deepening gulf between power and politics that is a defining feature of our contemporary liquid-modern world—the gulf between the ability to get things done and the capability of deciding what things need to be done, a capability once vested with the territorially sovereign state. This deepening gulf has rendered nation-states unable to deliver on their promises, giving rise to a widespread disenchantment with the idea that the future will improve the human condition and a mistrust in the ability of nation-states to make this happen. True to the utopian spirit, retrotopia derives its stimulus from the urge to rectify the failings of the present human condition—though now by resurrecting the failed and forgotten potentials of the past. Imagined aspects of the past, genuine or putative, serve as the main landmarks today in drawing the road-map to a better world. Having lost all faith in the idea of building an alternative society of the future, many turn instead to the grand ideas of the past, buried but not yet dead. Such is retrotopia, the contours of which are examined by Zygmunt Bauman in this sharp dissection of our contemporary romance with the past.
Author: G.A. Fava
Publisher: Karger Medical and Scientific Publishers
ISBN: 331805822X
Category : Psychology
Languages : en
Pages : 164
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Book Description
Well-Being Therapy (WBT) is the psychotherapeutic approach developed by Giovanni Fava, a world-renowned psychiatrist and psychotherapist, and the editor-in-chief of Psychotherapy and Psychosomatics. WBT is an innovative strategy that is based on monitoring psychological well-being, whereby the patient progressively learns how to make it grow. This type of therapy has enjoyed much success and is increasing in popularity around the world. The first part of this long-awaited book describes how the idea for WBT was formed, the first patient treated, and the current evidence that supports this approach. In Part II, Giovanni Fava provides the treatment manual of WBT, describing what each session entails, and includes many examples from his own cases. The last part covers some of the specific conditions for which WBT can be used and how sessions can be conducted. It includes sections on depression, mood swings, generalized anxiety disorder, panic and agoraphobia, and posttraumatic stress disorder. There is also information on the application of WBT in interventions in school settings. Throughout the book, Dr. Fava keeps things interesting by peppering his narrative with anecdotes from his medical career. The primary audience for this book is professionals within psychology, psychiatry, and other fields of medicine (e.g., family practice, pediatrics, and rehabilitation). However, the book is written in a relaxed, clear, and accessible style that also makes it of interest to counselors, educators, and family and friends of patients, not to mention patients themselves.
Author: Neil E. Green
Publisher: Saunders
ISBN:
Category : Medical
Languages : en
Pages : 648
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Book Description
This fully revised and updated pediatric companion to Browner et al.'s SKELETAL TRAUMA, 2nd Edition presents the most advanced techniques for managing musculoskeletal injuries in children and adolescents. State-of-the-art coverage by leading experts in pediatric orthopaedics and musculoskeletal trauma includes growth and development, pathology, and complications. The 2nd Edition features new chapters on soft tissue injuries and outcome assessment as well as expanded coverage of child abuse.
Author: Cesare Segre
Publisher: Bloomington : Indiana University Press
ISBN:
Category : Literary Criticism
Languages : en
Pages : 360
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Book Description
Author: Paolo Santangelo
Publisher: BRILL
ISBN: 9789004123601
Category : Social Science
Languages : en
Pages : 632
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Book Description
A pionering inquiry on the role, perception and representation of emotional sphere in traditional Chinese culture provides a fascinating contribution on a key anthropological problem, in order to understand not only pre-modern private history, but also contemporary Chinese society. The importance of this work goes beyond Chinese studies.
