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Author: A. Pullman
Publisher: Springer Science & Business Media
ISBN: 9400954662
Category : Science
Languages : en
Pages : 334
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Book Description
In 1980. a distinguished group of scientists gathered In Washington. D. C. for an International Symposium on Aging and Cancer. Among the recommendations of this Symposium was to convene a future meeting to discuss the molecular basis for Interrelationships between aging and cancer when the appropriate scientific knowledge was available. That same year. the 13th Jerusalem Symposium on Quantum Chemistry and Biochemistry entitled ·Carcl nogenesls : Fundamental Mechanisms and Environmental Effects·. was held. attended by some 50 International authorities In this field. At this meeting. It became clear that the fundamental process of carcinogenesis 15 Intimately associated with differentiation. which must also be mechanistically related to aging. It was therefore proposed that the next Jerusalem Symposium on Cancer could provide the appropriate forum for the study on the Interrelationship among cancer. aging and differentiation. The Impressive advances In our knowledge of the nature of the genome through molecular genetic and physical chemical techniques have now provided the opportunity to examine the Interrelationships between these complex biolo gical processes. Through the Isolation. cloning and rearranging of genes we are able to dissect and manipulate the genome In a fashion that was unanticipated only a decade ago. At the same time. the Increase In longevity and the Increased numbers of Individuals entering the last decades of life where cancer Incidences are highest raise the profound and practical question of whether aging and cancer are linked through common mechanisms.
Author: A. Pullman
Publisher: Springer Science & Business Media
ISBN: 9400954662
Category : Science
Languages : en
Pages : 334
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Book Description
In 1980. a distinguished group of scientists gathered In Washington. D. C. for an International Symposium on Aging and Cancer. Among the recommendations of this Symposium was to convene a future meeting to discuss the molecular basis for Interrelationships between aging and cancer when the appropriate scientific knowledge was available. That same year. the 13th Jerusalem Symposium on Quantum Chemistry and Biochemistry entitled ·Carcl nogenesls : Fundamental Mechanisms and Environmental Effects·. was held. attended by some 50 International authorities In this field. At this meeting. It became clear that the fundamental process of carcinogenesis 15 Intimately associated with differentiation. which must also be mechanistically related to aging. It was therefore proposed that the next Jerusalem Symposium on Cancer could provide the appropriate forum for the study on the Interrelationship among cancer. aging and differentiation. The Impressive advances In our knowledge of the nature of the genome through molecular genetic and physical chemical techniques have now provided the opportunity to examine the Interrelationships between these complex biolo gical processes. Through the Isolation. cloning and rearranging of genes we are able to dissect and manipulate the genome In a fashion that was unanticipated only a decade ago. At the same time. the Increase In longevity and the Increased numbers of Individuals entering the last decades of life where cancer Incidences are highest raise the profound and practical question of whether aging and cancer are linked through common mechanisms.
Author: A. Pullman
Publisher:
ISBN: 9789400954670
Category :
Languages : en
Pages : 356
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Book Description
Author: A. Pullman
Publisher: Springer Science & Business Media
ISBN: 9401137285
Category : Science
Languages : en
Pages : 595
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Book Description
One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.
Author: A. Pullman
Publisher: Springer Science & Business Media
ISBN: 9401127182
Category : Science
Languages : en
Pages : 500
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Book Description
The 25th Jerusalem Symposium represents a most significant highlight in the development and history of these meetings. Living within the decimal system we have celebrated with much pleasure the lath and the 20th Jerusalem Symposia. With this one we experience a feeling of particular satisfaction because 25 years is different from, is more than, two decades and a half. It is a quarter of a century. It seems thus as if we have changed the dimension of our endeavour. In no way do we loose the sense of modesty with respect to the significance of these meetings. For the organizers, however, they do represent a continuity of efforts which we feel happy to have been able to carry out. At this occasion it seems useful to say a few words about the origin of the Jerusalem Symposia and to recall the name of a colleague who played an essential role in their creation and has been a most efficient and devoted co organizer of the seven first of them. This was Professor Ernst Bergmann, one of the most distinguished founders of Israeli Science and a world famous physico-organic chemist.
Author: Joshua Jortner
Publisher: Springer Science & Business Media
ISBN: 9401107866
Category : Science
Languages : en
Pages : 562
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Book Description
The Twenty Sixth Jerusalem Symposium reflected the high standards of these distinguished scientific meetings, which convene once a year at the Israel Academy of Sciences and Humanities in Jerusalem to discuss a specific topic in the broad area of quantum chemistry and biochemistry. The topic at this year's Jerusalem Symposium was reaction dynamics in clusters and condensed phases, which constitutes a truly interdisciplinary subject of central interest in the areas of chemical dynamics, kinetics, photochemistry and condensed matter chemical physics. The main theme of the Symposium was built around the exploration of the interrelationship between the dynamics in large finite clusters and in infinite bulk systems. The main issues addressed microscopic and macroscopic sol vation phenomena, cluster and bulk spectroscopy, photodissociation and vibrational predissociation, cage effects, interphase dynamics, reaction dynamics and energy transfer in clusters, dense fluids, liquids, solids and biophysical systems. The interdisciplinary nature of this research area was deliberated by intensive and extensive interactions between modern theory and advanced experimental methods. This volume provides a record of the invited lectures at the Symposium.
Author: Joshua Jortner
Publisher: Springer Science & Business Media
ISBN: 9401126429
Category : Science
Languages : en
Pages : 566
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Book Description
The Twenty Fourth Jerusalem Symposium reflected the high standards of these distinguished scientific meetings, which convene once a year at the Israel Academy of Sciences and Humanities in Jerusalem to discuss a specific topic in the broad area of quantum chemistry and biochemistry. The topic at this year's Jerusalem Symposium was mode selective chemistry, which constitutes a truly interdisciplinary subject of central interest in the areas of chemical physics, photochemistry and photobiology. The main theme of the Symposium was built around the exploration of the possibility and conditions for non-statistical reaction dynamics in molecules, van der Waals molecules, clusters and condensed phases. The main issues addressed photoselective and coherent excitation modes, bottlenecks for intramolecular vibrational energy redistribution, the consequences of the internal structure of many-atom systems and of rotational vibrational level structure for intramolecular dynamics, bond selective photodissociation, ultrafast chemical clocks for energy disposal, coherent control of photochemical reactions and nonstatistical unimolecular reaction dynamics. The interdisciplinary nature of this research area was deliberated by intensive and extensive interactions between theory and experiment. This volume provides a record of the invited lectures at the Symposium.
Author: Joshua Jortner
Publisher: Springer Science & Business Media
ISBN: 9400904894
Category : Science
Languages : en
Pages : 442
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Book Description
The Twenty-Second Jerusalem Symposium reflected the high standards of these distinguished scientific meetings, which convene once a year at the Israel Academy of Sciences and Humanities in Jerusalem to discuss a specific topic in the broad area of quantum chemistry and 'biochemistry. The topic at this year's Jerusalem Symposium was Perspectives in Photosynthesis, which constitutes a truly interdisciplinary subject of central interest to biophysicists, and biologists. chemists The main theme of the Symposium was built around a conceptual framework for the acquisition, storage and useful disposal of energy in photosynthetic reaction centres. Emphasis was placed on the elucidation of primary charge separation processes in photosynthesis and their exploration within the framework of the electron transfer theory, on the interrelationship between structural data, inter actions and electron transfer kinetics, and on the role of protein dynamics in primary processes in photosynthesis. The interdisciplinary nature of these research areas was deliberated by intensive and extensive interactions between scientists from different disciplines and between theory and experiment. This volume provides a record of the invited lectures at the Symposium.
Author: A. Pullman
Publisher: Springer Science & Business Media
ISBN: 9400930755
Category : Science
Languages : en
Pages : 558
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Book Description
The Symposium on "Transport through Membranes : Carriers. Channels and Pumps" Inaugurates the third decade of the Jerusalem Symposia. It enlarges substantially their conceptual scope by Introducing a new subject not treated there previously. In fact. It Is a topic particularly well suited for the general object of these International meetings which Is to reassemble In an exhaustive Interdisciplinary discussion chemists. physicists and biologists. theoreticians and experimentalists. The main theme of the Symposium was the presentation and evaluation of the most up-to-date data on the structural and dynamic aspects of transport through membranes within the three main pathways: through carriers. channels and pumps. This goal was fully achieved thanks to the participation of a most outstanding assembly of world's experts In the field. We wish to thank Madame Pullman. the real organizer and mainspring of this meeting. for having composed a most exciting and excellent program and for carrying It out successfully. As the twenty preceding ones this Symposium was held under the auspices of the Israel Academy of Sciences and Humanities and the Hebrew University of Jerusalem. It was sponsored by the Instltut de Blologle Physlco Chimique. Fondatlon Edmond de Rothschild of Paris. We wish to express once again our gratitude to the Baron Edmond de Rothschild for his constant and generous support which makes this continuous endeavour possible.
Author: Francisco Feo
Publisher: Springer Science & Business Media
ISBN: 1475796404
Category : Science
Languages : en
Pages : 646
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Book Description
About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.
Author: Jean-Paul Behr
Publisher: John Wiley & Sons
ISBN: 0470511400
Category : Science
Languages : en
Pages : 336
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Book Description
Published 100 years after Emil Fischer first proposed the lock-and-key principle, this volume provides a complete review of the subject to date and offers suggestions for futher research. The major impact of the lock-and-key principle on the chemical, biomedical and materials sciences is discussed by leaders in the field, with chapters dedicated to molecular recognition, nucleic acid and protein chemistry, crystallography and the development of Emil Fischer's initial ideas. The Lock-and-Key Principle is the most up-to-date review of progress in supramolecular chemistry and the lock-and-key principle and will become the essential guide to the past, present and future of this remarkable principle.
