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Author: Wei Zhang
Publisher: John Wiley & Sons
ISBN: 1119075637
Category : Science
Languages : en
Pages : 471
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Book Description
The first and only exhaustive review of the theory, thermodynamic fundamentals, mechanisms, and design principles of dynamic covalent systems Dynamic Covalent Chemistry: Principles, Reactions, and Applications presents a comprehensive review of the theory, thermodynamic fundamentals, mechanisms, and design principles of dynamic covalent systems. It features contributions from a team of international scientists, grouped into three main sections covering the principles of dynamic covalent chemistry, types of dynamic covalent chemical reactions, and the latest applications of dynamic covalent chemistry (DCvC) across an array of fields. The past decade has seen tremendous progress in (DCvC) research and industrial applications. The great synthetic power and reversible nature of this chemistry has enabled the development of a variety of functional molecular systems and materials for a broad range of applications in organic synthesis, materials development, nanotechnology, drug discovery, and biotechnology. Yet, until now, there have been no authoritative references devoted exclusively to this powerful synthetic tool, its current applications, and the most promising directions for future development. Dynamic Covalent Chemistry: Principles, Reactions, and Applications fills the yawning gap in the world literature with comprehensive coverage of: The energy landscape, the importance of reversibility, enthalpy vs. entropy, and reaction kinetics Single-type, multi-type, and non-covalent reactions, with a focus on the advantages and disadvantages of each reaction type Dynamic covalent assembly of discrete molecular architectures, responsive polymer synthesis, and drug discovery Important emerging applications of dynamic covalent chemistry in nanotechnology, including both material- and bio-oriented directions Real-world examples describing a wide range of industrial applications for organic synthesis, functional materials development, nanotechnology, drug delivery and more Dynamic Covalent Chemistry: Principles, Reactions, and Applications is must-reading for researchers and chemists working in dynamic covalent chemistry and supramolecular chemistry. It will also be of value to academic researchers and advanced students interested in applying the principles of (DCvC) in organic synthesis, functional materials development, nanotechnology, drug discovery, and chemical biology.
Author: Wei Zhang
Publisher: John Wiley & Sons
ISBN: 1119075637
Category : Science
Languages : en
Pages : 471
Get Book Here
Book Description
The first and only exhaustive review of the theory, thermodynamic fundamentals, mechanisms, and design principles of dynamic covalent systems Dynamic Covalent Chemistry: Principles, Reactions, and Applications presents a comprehensive review of the theory, thermodynamic fundamentals, mechanisms, and design principles of dynamic covalent systems. It features contributions from a team of international scientists, grouped into three main sections covering the principles of dynamic covalent chemistry, types of dynamic covalent chemical reactions, and the latest applications of dynamic covalent chemistry (DCvC) across an array of fields. The past decade has seen tremendous progress in (DCvC) research and industrial applications. The great synthetic power and reversible nature of this chemistry has enabled the development of a variety of functional molecular systems and materials for a broad range of applications in organic synthesis, materials development, nanotechnology, drug discovery, and biotechnology. Yet, until now, there have been no authoritative references devoted exclusively to this powerful synthetic tool, its current applications, and the most promising directions for future development. Dynamic Covalent Chemistry: Principles, Reactions, and Applications fills the yawning gap in the world literature with comprehensive coverage of: The energy landscape, the importance of reversibility, enthalpy vs. entropy, and reaction kinetics Single-type, multi-type, and non-covalent reactions, with a focus on the advantages and disadvantages of each reaction type Dynamic covalent assembly of discrete molecular architectures, responsive polymer synthesis, and drug discovery Important emerging applications of dynamic covalent chemistry in nanotechnology, including both material- and bio-oriented directions Real-world examples describing a wide range of industrial applications for organic synthesis, functional materials development, nanotechnology, drug delivery and more Dynamic Covalent Chemistry: Principles, Reactions, and Applications is must-reading for researchers and chemists working in dynamic covalent chemistry and supramolecular chemistry. It will also be of value to academic researchers and advanced students interested in applying the principles of (DCvC) in organic synthesis, functional materials development, nanotechnology, drug discovery, and chemical biology.
Author: Luca D. D'Andrea
Publisher: John Wiley & Sons
ISBN: 1119044103
Category : Science
Languages : en
Pages : 578
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Book Description
Presenting a wide array of information on chemical ligation – one of the more powerful tools for protein and peptide synthesis – this book helps readers understand key methodologies and applications that protein therapeutic synthesis, drug discovery, and molecular imaging. • Moves from fundamental to applied aspects, so that novice readers can follow the entire book and apply these reactions in the lab • Presents a wide array of information on chemical ligation reactions, otherwise scattered across the literature, into one source • Features comprehensive and multidisciplinary coverage that goes from basics to advanced topics • Helps researchers choose the right chemical ligation technique for their needs
Author: Peter J. Cragg
Publisher: Springer Science & Business Media
ISBN: 9048125820
Category : Science
Languages : en
Pages : 267
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Book Description
The aim of this book is to return to the biomimicry and medicinal potential that inspired many of the early supramolecular chemists and to set it in the context of current advances in the field. Following an overview of supramolecular chemistry, the first section considers the efforts made to synthesize artificial systems that mimic biological entities. The second section addresses the application of supramolecular principles to molecular diagnostics with a particular emphasis on the ‘receptor-relayreporter’ motif. Many of the examples chosen have clinical importance. The third section takes the clinical diagnostic theme further and demonstrates the therapeutic applications of supramolecular chemistry through photodynamic therapy, drug delivery, and the potential for synthetic peptides to form antibiotic tubes. The short epilogue considers the potential for supramolecular solutions to be found for further challenges in biomimetic and therapeutic chemistry.
Author: Benjamin F. Cravatt
Publisher: Springer
ISBN: 3030111431
Category : Medical
Languages : en
Pages : 420
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Book Description
This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
Author: Joost N. H. Reek
Publisher: John Wiley & Sons
ISBN: 9783527629718
Category : Science
Languages : en
Pages : 211
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Book Description
This long-awaited first book on this exciting new field in organic and supramolecular chemistry explains the fundamentals as well as possible applications of DCC. Authored by the "Who's Who" of DCC it spans the whole range of topics: catalysts, sensors, polymers, ligands, receptors, concluding with a look at future developments and perspectives. All set to become the standard text in the field, this one-stop reference contains everything organic, catalytic, polymer, physical and biochemists need to know.
Author: W. Andy Tao
Publisher: John Wiley & Sons
ISBN: 1118970217
Category : Science
Languages : en
Pages : 449
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Book Description
PROVIDES STRATEGIES AND CONCEPTS FOR UNDERSTANDING CHEMICAL PROTEOMICS, AND ANALYZING PROTEIN FUNCTIONS, MODIFICATIONS, AND INTERACTIONS—EMPHASIZING MASS SPECTROMETRY THROUGHOUT Covering mass spectrometry for chemical proteomics, this book helps readers understand analytical strategies behind protein functions, their modifications and interactions, and applications in drug discovery. It provides a basic overview and presents concepts in chemical proteomics through three angles: Strategies, Technical Advances, and Applications. Chapters cover those many technical advances and applications in drug discovery, from target identification to validation and potential treatments. The first section of Mass Spectrometry-Based Chemical Proteomics starts by reviewing basic methods and recent advances in mass spectrometry for proteomics, including shotgun proteomics, quantitative proteomics, and data analyses. The next section covers a variety of techniques and strategies coupling chemical probes to MS-based proteomics to provide functional insights into the proteome. In the last section, it focuses on using chemical strategies to study protein post-translational modifications and high-order structures. Summarizes chemical proteomics, up-to-date concepts, analysis, and target validation Covers fundamentals and strategies, including the profiling of enzyme activities and protein-drug interactions Explains technical advances in the field and describes on shotgun proteomics, quantitative proteomics, and corresponding methods of software and database usage for proteomics Includes a wide variety of applications in drug discovery, from kinase inhibitors and intracellular drug targets to the chemoproteomics analysis of natural products Addresses an important tool in small molecule drug discovery, appealing to both academia and the pharmaceutical industry Mass Spectrometry-Based Chemical Proteomics is an excellent source of information for readers in both academia and industry in a variety of fields, including pharmaceutical sciences, drug discovery, molecular biology, bioinformatics, and analytical sciences.
Author: Miquel Vila-Perelló
Publisher: Humana
ISBN: 9781071604335
Category : Science
Languages : en
Pages : 0
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Book Description
This book provides a comprehensive overview of Expressed Protein Ligation (EPL), detailing methods and protocols to generate site-specifically modified proteins. Chapters include an overview of the protein semi-synthesis field, as well as related areas that have contributed to the development of EPL such as protein splicing and peptide synthesis. Following the introductory chapters, the rest of the book guides readers through protocols to perform EPL reactions, methods to synthesize peptide thioesters and to perform peptide and protein ligations, label proteins inside living cells, protocols for the semi-synthesis of phorphorylated, glycosylated and ubiquitylated proteins, synthesis and assembly of assymetrically modified nucleosomes, use of ligation auxiliaries and synthesis of cyclic proteins, as well as novel desulfurization strategies and use of selective Cys side chain protection to obtain precisely modified proteins.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Expressed Protein Ligation: Methods and Protocols will ensure successful implementation of protein semi-synthesis methods to further study the structure and function of proteins.
Author: Mitsuhiro Ebara
Publisher: William Andrew
ISBN: 0323374999
Category : Technology & Engineering
Languages : en
Pages : 364
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Book Description
Biomaterials Nanoarchitectonics, written from the perspectives of authors form NIMS and other researchers worldwide, provides readers with an explanation of the theory and techniques of nanoarchitectonics, exploring its applications in biomedical fields, including regenerative medicine, drug delivery, and diagnostic and treatment systems based on pathogenic mechanisms. The book also explains the use of nanomaterials that enable 'materials therapy', in which the materials themselves elicit a sustainable, curative effect from living tissue. - Authored by the team that coined the term nanoarchitectonics, who explain their approach to the design of smart/functional nanomaterials and their applications in the biomedical arena - Explores how materials designed and produced with nanoarchitectonics methods can be used to enhance the natural regenerative power of the human body - Enables scientists and researchers to gain a deeper understanding of the specific challenges of materials design at the nanoscale
Author: Richard B. M. Schasfoort
Publisher: Royal Society of Chemistry
ISBN: 1782627308
Category : Science
Languages : en
Pages : 555
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Book Description
Surface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events, this book provides a total system description including optics, fluidics and sensor surfaces for a wide researcher audience.
Author: Vivekkumar K Redasani
Publisher: Academic Press
ISBN: 0128035579
Category : Science
Languages : en
Pages : 84
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Book Description
Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs and their improvement. Prodrug Design reviews marketed compounds, the safety of promoieties, and a detailed classification of prodrugs organized by therapeutic area for easy reference. - Offers unique, detailed overview of Prodrug research and literature - Provides detailed chemical structures - Includes Prodrug listing by therapeutic area
