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Author: Ugo Ripamonti
Publisher: CRC Press
ISBN: 1482216175
Category : Medical
Languages : en
Pages : 210
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Book Description
The effects of the bone morphogenetic proteins (BMPs) family on bone formation are well documented, but the transforming growth factor (TGF)-beta ( isoforms are much less studied. The product of 20 years of study, Induction of Bone Formation in Primates: The Transforming Growth Factor- sums up editor Ugo Ripamonti's research into the osteogenic a
Author: Ugo Ripamonti
Publisher: CRC Press
ISBN: 1482216175
Category : Medical
Languages : en
Pages : 210
Get Book Here
Book Description
The effects of the bone morphogenetic proteins (BMPs) family on bone formation are well documented, but the transforming growth factor (TGF)-beta ( isoforms are much less studied. The product of 20 years of study, Induction of Bone Formation in Primates: The Transforming Growth Factor- sums up editor Ugo Ripamonti's research into the osteogenic a
Author: Ugo Ripamonti
Publisher: CRC Press
ISBN: 0429515308
Category : Medical
Languages : en
Pages : 208
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Book Description
The Geometric Induction of Bone Formation describes new biomimetic biomaterials that offer mechanistic osteogenic surfaces for the autonomous and spontaneous induction of bone formation without the addition of osteogenic soluble molecular signals of the transforming growth factor-β supergene family. The chapters frame our understanding of regenerative medicine in primate species, including humans. The goal is to unravel the fundamental biological mechanisms of bone formation unique to non-human and human primates. The broad target audience dovetails with several disciplines both in the academic and private biotech sectors primarily involved in molecular biology, tissue biology, tissue engineering, biomaterial science, and reconstructive, orthopedic, plastic, and dental surgery. Key Features Includes outstanding images of undecalcified whole mounted sections Summarizes non-human primate research – ideal for clinical translation Reviews methods for creating devices capable of making bone autonomously, i.e. an intrinsically osteo-inductive bioreactor and/or biomaterial Describes the spontaneous induction of bone formation including a whole spectrum of tissue biology, from basic molecular biology to clear-cut morphology and pre-clinical application in non-human primate species Intended for audiences in both academic research and the biotech industry
Author: M. Kathleen Pitirri
Publisher: CRC Press
ISBN: 1000439380
Category : Science
Languages : en
Pages : 271
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Book Description
Many complex traits define the human condition, including encephalization and bipedalism. The specific molecular signals and cellular processes producing these traits are the result of dramatic evolutionary change. At the same time, conservation of many of these developmental programs underlie both structure and function. Novel methodologies and techniques allow analysis of the collective behavior of cells, cell shapes, tissues, and organs. This volume demonstrates the essential role of cellular mechanisms in the evolutionary increase in the size and complexity of the primate brain. In addition, and concordant with encephalization, this book documents changes in the muscles and bones associated with the appearance of bipedalism. Genetic changes are the basis of these evolutionary changes, but transformation of genetic information into phenotypic outcomes occurs at the level of the cell, and this is the focus of the book. The goal is to encourage others to adopt evolutionary cell biology as a novel and necessary approach to the genotype-phenotype map of the diversification of primates, human variation, and human evolution. The contributors to this book utilize advances in genetic analysis, visualization of cells and tissues, and the merging of evolutionary developmental biology with evolutionary cell biology to address questions central to understanding the human and primate evolution. Key Features Explores mechanisms underlying trait distribution, dispersal, variation, and evolution through the direct testing of hypotheses especially with respect to patterns of encephalization, certain sensory modalities, and growth and life history specializations. Documents the advantages for anthropologists to work at the level of cells focusing on how genes provide instructions for cells to make structure and how environmental influences affect the behavior of cells. Illustrates the role cell biology plays with respect to encephalization, neocortical expansion, variation in facial morphology, locomotion, and dexterity. Describes novel methodologies and techniques allowing analysis of how the collective behavior of cells shapes tissues and organs. Related Titles Ripamonti, U., ed. Induction of Bone Formation in Primates: The Transforming Growth Factor-beta 3 (ISBN 978-0-3673-7740-3). Gordon, M. S., et al., eds. Animal Locomotion: Physical Principles and Adaptations (ISBN 978-0-3676-5795-6) Bianchi, L. Developmental Neurobiology (ISBN 978-0-8153-4482-7)
Author: Matthew Goldsmith
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
"Animals in space exploration studies serve both as a model for human physiology and as a mean to understand the physiological effects of microgravity. Animal experiments provided several advantages over human studies as they allow for post-mortem analysis of experimental subjects and larger sample sizes making statistical significance easier to achieve. To quantify the microgravity-induced changes to bone health in animals, we systematically searched Medline, Embase, Web of Science, BIOSIS, and NASA Technical reports. We selected 40 papers focusing on the bone health of 95 rats, 61 mice and 9 resus monkeys from 22 space missions ranging from 4 to 39 days in duration. The percentage difference from ground control in rodents was -24.1% [Confidence interval: -43.4,-4.9] for trabecular bone volume fraction and -5.9% [-8.0, -3.8] for cortical area, suggesting that trabecular bone is more affected than cortical bone by spaceflight in rodents. In primates, trabecular bone volume fraction was lower by -25.2% [-35.6, -14.7] in spaceflight animals compared to GC. Bone formation indices in rodent trabecular and cortical bone were significantly lower in microgravity. In contrast, osteoclast numbers were not affected in rats, and were variably affected in mice. Thus, microgravity induces bone deficits in rodents and primates likely through the suppression of bone formation"--
Author: Christian R. Abee
Publisher: Academic Press
ISBN: 0123978386
Category : Medical
Languages : en
Pages : 867
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Book Description
The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. - Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research - Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information - Includes four color images throughout
Author: Christian R. Abee
Publisher: Academic Press
ISBN: 0124159729
Category : Science
Languages : en
Pages : 3435
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Book Description
The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The publication emphasizes the biology and management, diseases, and biomedical models for nonhuman primate species most commonly used in research. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. The Biology and Management volume provides basic information on the natural biology of nonhuman primates and the current state of knowledge regarding captive management. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. - Now in four color throughout, making the book more visually stimulating to enhance learning and ease of use - Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in biomedical research - Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information
Author: T. Sam Lindholm
Publisher: World Scientific
ISBN: 9812706577
Category : Medical
Languages : en
Pages : 479
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Book Description
The bone morphogenetic protein (BMP) is a special growth factor for the induction of new bone formation. Today, the extract of the BMP originating from bone tissue as well as genetically modified BMPs, particularly BMP-2 and -7, can be used.Though the BMP as an implant is as yet an unregistered drug or medical tool in Europe and the US, specialists are confident that it will obtain final government approval based on the results of clinical tests conducted on more than 3000 patients.This important book focuses mainly on the clinical BMP treatment of patients OCo namely in orthopaedic cases (fractures, bone transplants, non-unions and pseudoarthroses), maxillofacial surgery (sinus lift before dental implantation), dental surgery (filling out of cavities) and spinal surgery (using a BMP implant instead of the patient's own bone)."
Author: Yuehuei H. An
Publisher: CRC Press
ISBN: 1420073567
Category : Medical
Languages : en
Pages : 650
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Book Description
The mechanical properties of whole bones, bone tissue, and the bone-implant interfaces are as important as their morphological and structural aspects. Mechanical Testing of Bone and the Bone-Implant Interface helps you assess these properties by explaining how to do mechanical testing of bone and the bone-implant interface for bone-related research
Author: Murugan Ramalingam
Publisher: CRC Press
ISBN: 1439881863
Category : Medical
Languages : en
Pages : 577
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Book Description
Through the integration of strategies from life science, engineering, and clinical medicine, tissue engineering and regenerative medicine hold the promise of new solutions to current health challenges. This rapidly developing field requires continual updates to the state-of-the-art knowledge in all of the aforementioned sciences. Tissue Engineering
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 776
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Book Description
