Impulsive Mathematical Models of Endocrine Regulation PDF Download
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Author: Alexander Medvedev
Publisher: Academic Press
ISBN: 9780128130537
Category : Technology & Engineering
Languages : en
Pages : 0
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Book Description
Impulsive Mathematical Models of Endocrine Regulation demonstrates recently-developed mathematical models portraying pulse-modulated regulation in endocrine systems, taking a pragmatic engineering stance by starting with the necessary theoretical background on analytical tools, progressing through a number of mathematical models of increasing complexity, and illustrating the feasibility and fidelity of the mathematical constructs on actual biological data. Compared to a commonplace, theory-oriented book on dynamical systems and control which typically presents a group of design or analysis techniques, the book originates from a real-life problem of fundamental value and introduces mathematical tools that have specifically been devised to solve it. Presents results on impulsive mathematical models of endocrine regulation in a systematic, comprehensive and accessible manner Introduces researchers and engineers specializing in dynamical systems to a rapidly-growing topic Provides biomedical engineering and biological researchers with mathematical modeling and analysis tools for continuous systems using episodic feedback exemplified by non-basal endocrine regulation
Author: Alexander Medvedev
Publisher: Academic Press
ISBN: 9780128130537
Category : Technology & Engineering
Languages : en
Pages : 0
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Book Description
Impulsive Mathematical Models of Endocrine Regulation demonstrates recently-developed mathematical models portraying pulse-modulated regulation in endocrine systems, taking a pragmatic engineering stance by starting with the necessary theoretical background on analytical tools, progressing through a number of mathematical models of increasing complexity, and illustrating the feasibility and fidelity of the mathematical constructs on actual biological data. Compared to a commonplace, theory-oriented book on dynamical systems and control which typically presents a group of design or analysis techniques, the book originates from a real-life problem of fundamental value and introduces mathematical tools that have specifically been devised to solve it. Presents results on impulsive mathematical models of endocrine regulation in a systematic, comprehensive and accessible manner Introduces researchers and engineers specializing in dynamical systems to a rapidly-growing topic Provides biomedical engineering and biological researchers with mathematical modeling and analysis tools for continuous systems using episodic feedback exemplified by non-basal endocrine regulation
Author: Ewart R. Carson
Publisher:
ISBN: 9780783728346
Category :
Languages : en
Pages : 418
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Book Description
Author: Marine Jacquier
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
The regulation of food intake and energy expenditure usually limits important loss or gain of body weight. Hormones (leptin, ghrelin, insulin) and nutrients (glucose, triglycerides) are among the main regulators of food intake. Leptin is also involved in leptin resistance, often associated with obesity and characterized by a reduced efficacy to regulate food intake. Mathematical models describing the dynamics of body weight have been used to assist clinical weight loss interventions or to study an experimentally inaccessible phenomenon, such as starvation experiments in humans. Modeling of the effect of hormones on body weight has however been largely ignored.In this thesis, we first consider a model of body weight regulation by hormones in rats, made of nonlinear differential equations. It describes the dynamics of food intake, body weight and energy expenditure, regulated by leptin, ghrelin and glucose. It is able to reproduce and predict the evolution of body weight and food intake in rats submitted to different patterns of caloric restriction, showing the importance of the adaptation of energy expenditure. Second, we introduce the first model of leptin resistance development, based on the regulation of food intake by leptin and leptin receptors. We show that healthy individuals may become leptin resistant and obese due to perturbations in food intake or leptin concentration. Finally, modifications of these models are presented, characterized by simplified yet realistic body weight dynamics. The models prove able to fit the previous, as well as new sets of experimental data and allow to build a complete model combining both previous models regulatory mechanisms.
Author: Hugo van den Berg
Publisher: CRC Press
ISBN: 0429643527
Category : Mathematics
Languages : en
Pages : 138
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Book Description
Hormones as Tokens of Selection addresses deep questions in biology: How are biological systems controlled? How can one formulate general theories of homeostasis and control and instantiate such theories in mathematical models? How can one use evolutionary arguments to guide our answers to these questions, recognising that the control mechanisms themselves are a product of evolution? Biological systems are exceptionally varied and extremely difficult to understand, because they are complex and experimentation remains limited relative to the challenges at hand. Moreover, biological phenomena occur at a wide range of temporal and spatial scales. Such a deeply convoluted subject calls for a unifying and coherent theoretical foundation — one which recognises and departs from the primary importance of mathematical modelling and key physicochemical principles to theory formation in the life sciences. This Focus monograph proposes and outlines such a foundation, departing from the deceptively simple proposition that hormones are tokens of evolutionary pressures. Features Provides a coherent and unified approach to a multifaceted problem Pays close attention to both the biological and mathematical modelling aspects of the subject matter, exploring the philosophical background where appropriate Written in a concise and innovative style
Author: Changming Sun
Publisher: Springer
ISBN: 3319109847
Category : Computers
Languages : en
Pages : 286
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Book Description
With an emphasis on applications of computational models for solving modern challenging problems in biomedical and life sciences, this book aims to bring collections of articles from biologists, medical/biomedical and health science researchers together with computational scientists to focus on problems at the frontier of biomedical and life sciences. The goals of this book are to build interactions of scientists across several disciplines and to help industrial users apply advanced computational techniques for solving practical biomedical and life science problems. This book is for users in the fields of biomedical and life sciences who wish to keep abreast with the latest techniques in signal and image analysis. The book presents a detailed description to each of the applications. It can be used by those both at graduate and specialist levels.
Author: Jorge Garza Ulloa
Publisher: Academic Press
ISBN: 0128125950
Category : Technology & Engineering
Languages : en
Pages : 664
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Book Description
Applied Biomechatronics Using Mathematical Models provides an appropriate methodology to detect and measure diseases and injuries relating to human kinematics and kinetics. It features mathematical models that, when applied to engineering principles and techniques in the medical field, can be used in assistive devices that work with bodily signals. The use of data in the kinematics and kinetics analysis of the human body, including musculoskeletal kinetics and joints and their relationship to the central nervous system (CNS) is covered, helping users understand how the complex network of symbiotic systems in the skeletal and muscular system work together to allow movement controlled by the CNS. With the use of appropriate electronic sensors at specific areas connected to bio-instruments, we can obtain enough information to create a mathematical model for assistive devices by analyzing the kinematics and kinetics of the human body. The mathematical models developed in this book can provide more effective devices for use in aiding and improving the function of the body in relation to a variety of injuries and diseases. Focuses on the mathematical modeling of human kinematics and kinetics Teaches users how to obtain faster results with these mathematical models Includes a companion website with additional content that presents MATLAB examples
Author: Ewart R. Carson
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 424
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Book Description
Introduces the concepts, methods and techniques of model formulation, identification, and validation as applicable to metabolic and endocrine processes. Shows how modeling can be used to provide a concise description of complex dynamic processes, to test hypotheses concerning physiological and biochemical structure, and to estimate physiological quantities (parameters) that otherwise would not be directly accessible to measurement. Includes numerous examples and case studies.
Author:
Publisher: ScholarlyEditions
ISBN: 1490108246
Category : Technology & Engineering
Languages : en
Pages : 585
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Book Description
Issues in Systems Engineering / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Systems and Control Engineering. The editors have built Issues in Systems Engineering: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Systems and Control Engineering in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Systems Engineering: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: John A.H. Wass
Publisher: Oxford University Press, USA
ISBN: 0199235295
Category : Medical
Languages : en
Pages : 2158
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Book Description
Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.
Author: Wassim M. Haddad
Publisher: Princeton University Press
ISBN: 1400865247
Category : Mathematics
Languages : en
Pages : 522
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Book Description
This book develops a general analysis and synthesis framework for impulsive and hybrid dynamical systems. Such a framework is imperative for modern complex engineering systems that involve interacting continuous-time and discrete-time dynamics with multiple modes of operation that place stringent demands on controller design and require implementation of increasing complexity--whether advanced high-performance tactical fighter aircraft and space vehicles, variable-cycle gas turbine engines, or air and ground transportation systems. Impulsive and Hybrid Dynamical Systems goes beyond similar treatments by developing invariant set stability theorems, partial stability, Lagrange stability, boundedness, ultimate boundedness, dissipativity theory, vector dissipativity theory, energy-based hybrid control, optimal control, disturbance rejection control, and robust control for nonlinear impulsive and hybrid dynamical systems. A major contribution to mathematical system theory and control system theory, this book is written from a system-theoretic point of view with the highest standards of exposition and rigor. It is intended for graduate students, researchers, and practitioners of engineering and applied mathematics as well as computer scientists, physicists, and other scientists who seek a fundamental understanding of the rich dynamical behavior of impulsive and hybrid dynamical systems.
