Impedance Based Sensing Principles for Microfluidic Lab-on-a-chip Systems PDF Download
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 163
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Book Description
The rapidly developing field of lab-on-a-chip systems aims at combining various microfluidic components in the construction of fully functional, self-contained devices for robust, portable, large-scale integrated chemical and biological processing and analysis. To-date such devices have demonstrated applications in fundamental cellular and microbiology studies, analytical and combinatorial chemistry for drug discovery and high throughput screening, point-of-care and clinical diagnostics, genomics, proteomics as well as systems for detection of bio-warfare and chemical warfare agents. Existing microfluidic components remain limited in their capabilities, ease of integration, and scope. This work aimed to expand the field by demonstrating innovative techniques that confer functionality without sacrificing simplicity and ease of integration in lab-on-a-chip systems. Impedance-based techniques were developed to monitor volume changes of a sensing element in a microfluidic channel; allowing detection of various useful parameters in a lab-chip. Two systems were designed, fabricated, and tested to demonstrate the principle. The first used an electrolytic bubble sensing element; which is a direct extension of bubble-based microfluidic technologies. The second system relied on biological cells as sensing elements in a microfluidic channel. As such, this work broadly evolved from impedance-based sensing techniques that can be used for closed-loop control of fluid handling components to robust applications in cell-based microfluidic assays. In this thesis, device design considerations, fabrication techniques and characterization are presented. Fundamental studies of bubble growth, dynamics and configuration in a microchannel are described providing the basis for a bubble sensor which can detect effects of pressure and interfacial tension in a microfluidic system. The significance and fundamental principles of cell volume are discussed followed by the development and characterization of a microfluidic cell volume sensor. Using primary rat astrocytes and E. coli, various applications of the sensor are demonstrated, including the ability to study cell volume regulation, screen bioactive reagents and the effects of pharmaceuticals on mammalian and bacterial cells.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 163
Get Book Here
Book Description
The rapidly developing field of lab-on-a-chip systems aims at combining various microfluidic components in the construction of fully functional, self-contained devices for robust, portable, large-scale integrated chemical and biological processing and analysis. To-date such devices have demonstrated applications in fundamental cellular and microbiology studies, analytical and combinatorial chemistry for drug discovery and high throughput screening, point-of-care and clinical diagnostics, genomics, proteomics as well as systems for detection of bio-warfare and chemical warfare agents. Existing microfluidic components remain limited in their capabilities, ease of integration, and scope. This work aimed to expand the field by demonstrating innovative techniques that confer functionality without sacrificing simplicity and ease of integration in lab-on-a-chip systems. Impedance-based techniques were developed to monitor volume changes of a sensing element in a microfluidic channel; allowing detection of various useful parameters in a lab-chip. Two systems were designed, fabricated, and tested to demonstrate the principle. The first used an electrolytic bubble sensing element; which is a direct extension of bubble-based microfluidic technologies. The second system relied on biological cells as sensing elements in a microfluidic channel. As such, this work broadly evolved from impedance-based sensing techniques that can be used for closed-loop control of fluid handling components to robust applications in cell-based microfluidic assays. In this thesis, device design considerations, fabrication techniques and characterization are presented. Fundamental studies of bubble growth, dynamics and configuration in a microchannel are described providing the basis for a bubble sensor which can detect effects of pressure and interfacial tension in a microfluidic system. The significance and fundamental principles of cell volume are discussed followed by the development and characterization of a microfluidic cell volume sensor. Using primary rat astrocytes and E. coli, various applications of the sensor are demonstrated, including the ability to study cell volume regulation, screen bioactive reagents and the effects of pharmaceuticals on mammalian and bacterial cells.
Author: Geeta Bhatt
Publisher: CRC Press
ISBN: 100380862X
Category : Technology & Engineering
Languages : en
Pages : 283
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Book Description
This book includes basics of impedance spectroscopy technology, substrate compatibility issues, integration capabilities, and several applications in the detection of different analytes. It helps explore the importance of this technique in biological detection, related micro/nanofabricated platforms and respective integration, biological synthesis schemes to carry out the detection, associated challenges, and related future directions. The various qualitative/quantitative findings of several modules are summarized in the form of the detailed descriptions, schematics, and tables. Features: Serves as a single source for exploring underlying fundamental principles and the various biological applications through impedance spectroscopy. Includes chapters based on nonbiological applications of impedance spectroscopy and IoT-enabled impedance spectroscopy-based methods for detection. Discusses derivations, substrates, applications, and several integrations. Describes micro/nanofabrication of impedance-based biological sensors. Reviews updated integrations like digital manufacturing and IoT. This book is aimed at researchers and graduate students in material science, impedance spectroscopy, and biosensing.
Author: Jaime Castillo-León
Publisher: Springer
ISBN: 3319086871
Category : Technology & Engineering
Languages : en
Pages : 246
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Book Description
This book covers all the steps in order to fabricate a lab-on-a-chip device starting from the idea, the design, simulation, fabrication and final evaluation. Additionally, it includes basic theory on microfluidics essential to understand how fluids behave at such reduced scale. Examples of successful histories of lab-on-a-chip systems that made an impact in fields like biomedicine and life sciences are also provided. This book also: · Provides readers with a unique approach and toolset for lab-on-a-chip development in terms of materials, fabrication techniques, and components · Discusses novel materials and techniques, such as paper-based devices and synthesis of chemical compounds on-chip · Covers the four key aspects of development: basic theory, design, fabrication, and testing · Provides readers with a comprehensive list of the most important journals, blogs, forums, and conferences where microfluidics and lab-on-a-chip news, methods, techniques and challenges are presented and discussed, as well as a list of companies providing design and simulation support, components, and/or developing lab-on-a-chip and microfluidic devices.
Author: Paul C.H. Li
Publisher: CRC Press
ISBN: 142002745X
Category : Medical
Languages : en
Pages : 529
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Book Description
The microfluidic lab-on-a-chip allows scientists to conduct chemical and biochemical analysis in a miniaturized format so small that properties and effects are successfully enhanced, and processes seamlessly integrated. This microscale advantage translates into greater sensitivity, more accurate results, and better information. Microfluidic
Author: Jaime Punter-Villagrasa
Publisher: Springer
ISBN: 3319648012
Category : Science
Languages : en
Pages : 250
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Book Description
The book presents the conception and realization of a pervasive electronic architecture for electrochemical applications, focusing on electronic instrumentation design and device development, particularly in electrochemical Point-of-Care and Lab-on-a-Chip devices, covering examples based on amperometric (DC) and impedance detection (AC) techniques. The presented electronics combine tailored front-end instrumentation and back-end data post-processing, enabling applications in different areas, and across a variety of techniques, analytes, transducers and environments. It addresses how the electronics are designed and implemented with special interest in the flow process: starting from electronic circuits and electrochemical biosensor design to a final validation and implementation for specific applications. Similarly, other important aspects are discussed throughout the book, such as electrochemical techniques, different analytes, targets, electronics reliability and robustness. The book also describes the use of the presented electronics in different electrochemical applications through some examples: instantaneous and non-destructive cellular monitoring and portable glucose monitoring device. Moreover, the book aims to introduce a comprehensive approach to electronic circuits, techniques and electrochemical sensors in POC devices to a general audience of students in biomedical and electronics engineering, scientists, and engineers.
Author: Wing Cheung Mak
Publisher: Elsevier
ISBN: 012823847X
Category : Technology & Engineering
Languages : en
Pages : 370
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Book Description
Microfluidic Biosensors provides a comprehensive overview covering the most recent emerging technologies on the design, fabrication, and integration of microfluidics with transducers. These form various integrated microfluidic biosensors with device configurations ranging from 2D to 4D levels. Coverage also includes advanced printed microfluidic biosensors, flexible microfluidics for wearable biosensors, autonomous lab-on-a-chip biosensors, CMOS-base microanalysis systems, and microfluidic devices for mobile phone biosensing. The editors and contributors of this book represent both academia and industry, come from a varied range of backgrounds, and offer a global perspective. This book discusses the design and principle of microfluidic systems and uses them for biosensing applications. The microfluidic fabrication technologies covered in this book provide an up-to-date view, allowing the community to think of new ways to overcome challenges faced in this field. The focus is on existing and emerging technologies not currently being analyzed extensively elsewhere, providing a unique perspective and much-needed content. The editors have crafted this book to be accessible to all levels of academics from graduate students, researchers, and professors working in the fields of biosensors, microfluidics design, material science, analytical chemistry, biomedical devices, and biomedical engineering. It can also be useful for industry professionals working for microfluidic device manufacturers, or in the industry of biosensors and biomedical devices. - Presents an in-depth overview of microfluidic biosensors and associated emerging technologies such as printed microfluidics and novel transducers - Addresses a range of microfluidic biosensors with device configurations ranging from 2D to 4D levels - Includes the commercialization aspects of microfluidic biosensors that provide insights for scientists and engineers in research and development
Author: Francesco Piraino
Publisher: CRC Press
ISBN: 1351650483
Category : Technology & Engineering
Languages : en
Pages : 226
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Book Description
This book provides a current view of the research and commercial landscape of diagnostics devices, particularly those that utilize microscale technologies, intended for both patient and laboratory use. Common diagnostic devices that are based on microfluidic principles include glucose sensors for diabetic patients and over-the-counter pregnancy tests. Other diagnostic devices are being developed to quickly test a patient for bacterial and viral infections, and other diseases. The chapters, written by experts from around the world, discuss how to fabricate, apply, and market microfluidic diagnostic chips – for lab and at-home use. Most importantly, the book also contains a discussion of topics relevant to the private sector, including patient-focused, market-oriented development of diagnostics devices. Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 3.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781498772938_oachapter9.pdf
Author: Arpana Parihar
Publisher: Royal Society of Chemistry
ISBN: 1837673489
Category : Technology & Engineering
Languages : en
Pages : 694
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Book Description
The global miniature devices market is poised to surpass a valuation of $12–$15 billion USD by the year 2030. Lab-on-a-chip (LOC) devices are a vital component of this market. Comprising a network of microchannels, electrical circuits, sensors, and electrodes, LOC is a miniaturized integrated device platform used to streamline day-to-day laboratory functions, run cost-effective clinical analyses and curb the need for centralized instrumentation facilities in remote areas. Compact design, portability, ease of operation, low sample volume, short reaction time, and parallel investigation stand as the pivotal factors driving the widespread acceptance of LOC within the biomedical community. In this book, the Editors meticulously explore LOC through three key ‘Ts’: Theories (microfluidics, microarrays, instrumentation, software); Technologies (additive manufacturing, artificial intelligence, computational thinking, smart consumables, scale-up tactics, and biofouling); and Trends (biomedical analysis, point-of-care diagnostics, personalized healthcare, bioactive synthesis, disease diagnosis, and space applications) This comprehensive text not only provides readers with a thorough understanding of the current advancements in the LOC domain but also offers valuable insights to support the utilization of miniaturized devices for enhanced healthcare practices. Aimed at career researchers looking for instruction in the topic and newcomers to the area, the book is also useful for undergraduate and postgraduate students embarking on new studies or for those interested in reading about the LOC platform.
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 924
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Book Description
Author: Fatima H Labeed
Publisher: Royal Society of Chemistry
ISBN: 1849737606
Category : Science
Languages : en
Pages : 295
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Book Description
The concept of a miniaturised laboratory on a disposable chip is now a reality, and in everyday use in industry, medicine and defence. New devices are launched all the time, prompting the need for a straightforward guide to the design and manufacture of lab-on-a-chip (LOC) devices. This book presents a modular approach to the construction and integration of LOC components in detection science. The editors have brought together some of the leading experts from academia and industry to present an accessible guide to the technology available and its potential. Several chapters are devoted to applications, presenting both the sampling regime and detection methods needed. Further chapters describe the integration of LOC devices, not only with each other but also into existing technologies. With insights into LOC applications, from biosensing to molecular and chemical analysis, and presenting scaled-down versions of existing technology alongside unique approaches that exploit the physics of the micro and nano-scale, this book will appeal to newcomers to the field and practitioners requiring a convenient reference.
