Immunosurveillance, Immunodeficiencies and Lymphoproliferations PDF Download
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Author: S.H. Oertel
Publisher: Springer Science & Business Media
ISBN: 364256352X
Category : Medical
Languages : en
Pages : 436
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Book Description
This book covers lymphoproliferative disorders in patients with congenital or acquired immunodeficiencies. Acquired immunodeficiencies are caused by infections with the human immunodeficiency virus or arise following immunosuppressive therapy administered after organ transplantation or to treat connective tissue diseases such as rheumatoid arthritis. It was recently discovered that various diseases or therapeutic modalities that induce a state of immunosuppression may cause virally driven lymphoproliferations. This book summarizes for the first time this group of immunodeficiency-associated lymphoproliferations.
Author: S.H. Oertel
Publisher: Springer Science & Business Media
ISBN: 364256352X
Category : Medical
Languages : en
Pages : 436
Get Book Here
Book Description
This book covers lymphoproliferative disorders in patients with congenital or acquired immunodeficiencies. Acquired immunodeficiencies are caused by infections with the human immunodeficiency virus or arise following immunosuppressive therapy administered after organ transplantation or to treat connective tissue diseases such as rheumatoid arthritis. It was recently discovered that various diseases or therapeutic modalities that induce a state of immunosuppression may cause virally driven lymphoproliferations. This book summarizes for the first time this group of immunodeficiency-associated lymphoproliferations.
Author: S.H. Oertel
Publisher: Springer Science & Business Media
ISBN: 9783540422822
Category : Medical
Languages : en
Pages : 436
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Book Description
This book covers lymphoproliferative disorders in patients with congenital or acquired immunodeficiencies. Acquired immunodeficiencies are caused by infections with the human immunodeficiency virus or arise following immunosuppressive therapy administered after organ transplantation or to treat connective tissue diseases such as rheumatoid arthritis. It was recently discovered that various diseases or therapeutic modalities that induce a state of immunosuppression may cause virally driven lymphoproliferations. This book summarizes for the first time this group of immunodeficiency-associated lymphoproliferations.
Author: Macfarlane Burnet
Publisher: Elsevier
ISBN: 1483159221
Category : Medical
Languages : en
Pages : 289
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Book Description
Immunological Surveillance
Author: Richard T. Smith
Publisher: Elsevier
ISBN: 0323146260
Category : Nature
Languages : en
Pages : 553
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Book Description
Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.
Author: Amos Etzioni
Publisher: Academic Press
ISBN: 0124115543
Category : Medical
Languages : en
Pages : 377
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Book Description
Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future. This book provides an understanding of the process going from clinical problem to lab and back to the clinic, based on historical experiences. Its chapters proceed from the discovery of the T and B cell lineages through the first BMT for immunodeficiency disorder; lab investigation and gene therapy for PID; the discovery of the gene for AT and its function; understanding cytokine defects; and many other stops along the way. - Facilitates communication among physicians and other investigators concerned with immunological and inflammatory diseases - Summarizes for the first time all the known facts from 60 years of primary immunodeficiency research, and teaches how an important field in medicine was established - Provides stimulating discussions on developing new medical therapiesHighlights the importance of studying humans to understand mechanisms of disease that affect humans
Author: David T. Purtilo
Publisher: Springer Science & Business Media
ISBN: 1468447602
Category : Medical
Languages : en
Pages : 489
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Book Description
The discoveries of Burkitt, Epstein, and Henle have laid the foundation for continuing generation of information regarding the mechanisms of induction of diseases by Epstein-Barr virus. The discovery of the virus two decades ago resulted from clinical and basic science collaborative studies on Burkitt lymphoma. Subse quently, nasopharyngeal carcinoma and infectious mononucleosis have been linked etiologically with the virus. During the first decade of research following the discovery of the virus, the mechanisms for the induction of BL, NPC, and IM were sought. At that time one prevailing view was that individual oncogenic strains of EBV were responsible for the different disorders. Paralleling the development of immunology in the 1970's was the accrual of knowledge about immunological events occurring during IM. These studies suggest that immune defense mechanisms deter mine the outcome of this viral infection rather than different viral strains. During the early 1970's, Starzl and Penn and Gatti and Good had noted an increased frequency of malignancy in renal allograft recipients and children with primary immune deficiency disorders, respectively. These observations provoked investigators to restudy the role of immune surveillance against malignancy. At that time immune surveillance was thought to occur against tumor-specific antigens; thereby neoplasms were eliminated.
Author: Maria A. Proytcheva
Publisher: Cambridge University Press
ISBN: 0521881609
Category : Medical
Languages : en
Pages : 591
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Book Description
An accurate and up-to-date guide to the diagnosis of benign and malignant hematologic disorders of childhood, this is an excellent reference to ensure accurate diagnoses when evaluating peripheral blood, bone marrow, and lymph node disease. It will be a valuable tool in the practice of pathologists, pediatric pathologists, and hematopathologists.
Author: Edward J. Moticka
Publisher: Newnes
ISBN: 0123983754
Category : Medical
Languages : en
Pages : 396
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Book Description
A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. - Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles - Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology - Presents concepts such as the division of lymphocytes into functionally different populations in their historical context - Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells
Author: Jacques Descotes
Publisher: Elsevier
ISBN: 0080472990
Category : Science
Languages : en
Pages : 414
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Book Description
This is a review of clinical adverse effects on the human immune system that may occur following drug treatments and chemcical exposures. Current and prospective models and assays that can be used to predict these adverse effects in animal toxicity studies or in human beings are described.
Author: George Fedoriw
Publisher: Elsevier Health Sciences
ISBN: 0323416683
Category : Medical
Languages : en
Pages : 201
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Book Description
Dr. George Fedoriw leads the second issue presented in the Surgical Pathology Clinics on Hematopathology. Topics in this issue include: Evidence-based, high-value hematopathology; The expanding spectrum of follicular lymphoma; Lymphoid proliferations in the immunocompromised host; Reporting clinically relevant biomarkers of intermediate/high grade B-cell lymphomas; Transformation of lymphomas; T-cell lymphoproliferations: distinguishing benign from malignant; Lymphoma microenvironment and immunotherapy; Differentiating low grade lymphomas with non-specific immunophenotype; Molecular markers of myeloid leukemias and myelodysplastic syndromes; Update of myeloproliferative neoplasms; Mimics of myeloid neoplasms; Therapy effect: impact on bone marrow morphology. Each topic is written by a leader in pathology with expertise in hematopathology. The focus on these articles, as all in the series, is on Differential Diagnosis, with histologic images and tips for working with the most challenging aspects of these pathologies.
