Immunostimulatory DNA Sequences PDF Download
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Author: E. Raz
Publisher: Springer Science & Business Media
ISBN: 3642568661
Category : Medical
Languages : en
Pages : 202
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Book Description
This volume is a product of a collaborative effort and attempts to provide a wide and up-to-date coverage of information regarding the biology and on the potential application of immunostimulatory DNA. ISS hold great promise for influencing the immune response and the authors anticipate that the high efficacy and low toxicity observed in animal models will translate into success in a variety of human clinical applications.
Author: E. Raz
Publisher: Springer Science & Business Media
ISBN: 3642568661
Category : Medical
Languages : en
Pages : 202
Get Book Here
Book Description
This volume is a product of a collaborative effort and attempts to provide a wide and up-to-date coverage of information regarding the biology and on the potential application of immunostimulatory DNA. ISS hold great promise for influencing the immune response and the authors anticipate that the high efficacy and low toxicity observed in animal models will translate into success in a variety of human clinical applications.
Author: Eyal Raz
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: Ken J. Ishii
Publisher: CRC Press
ISBN: 1420068261
Category : Medical
Languages : en
Pages : 304
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Book Description
Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation
Author: Josef Thalhamer
Publisher: Springer Science & Business Media
ISBN: 3709104394
Category : Medical
Languages : en
Pages : 332
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Book Description
The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.
Author: Nicolay Ferrari
Publisher: John Wiley & Sons
ISBN: 1118537335
Category : Medical
Languages : en
Pages : 576
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Book Description
A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and research Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience. Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. While the idea of antisense oligonucleotides to target single genes dates back to the 1970's, most advances have taken place in recent years. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides. This valuable book reviews the fundamentals of oligonucleotides, with a focus on antisense oligonucleotide drugs, and reports on the latest research underway worldwide. • Helps readers understand antisense molecules and their targets, biochemistry, and toxicity mechanisms, roles in disease, and applications for safety and therapeutics • Examines the principles, practices, and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides • Provides guidelines for scientists in drug design and discovery to help improve efficiency, assessment, and the success of drug candidates • Includes interdisciplinary perspectives, from academia, industry, regulatory and from the fields of pharmacology, toxicology, biology, and medicinal chemistry Oligonucleotide-Based Drugs and Therapeutics belongs on the reference shelves of chemists, pharmaceutical scientists, chemical biologists, toxicologists and other scientists working in the pharmaceutical and biotechnology industries. It will also be a valuable resource for regulatory specialists and safety assessment professionals and an important reference for academic researchers and post-graduates interested in therapeutics, antisense therapy, and oligonucleotides.
Author: Gerald W. Volcheck
Publisher: Springer Science & Business Media
ISBN: 1597453153
Category : Medical
Languages : en
Pages : 502
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Book Description
Allergic diseases affect nearly one-fourth of the population and cause or contribute to significant chronic illness. Allergic diseases are common and are seen by a wide variety of health care providers. In Clinical Allergy: Diagnosis and Management, the author provides a practical clinical overview for the common disorders encountered in the specialty of Allergy. Designed to be easily readable and to provide clinically applicable information for both the nonallergist and allergist, the intent is to unravel the mystery of allergy. The introductory chapters focus on the human immune response, environmental allergens, and the different types of allergy testing. The subsequent chapters focus on the common allergic conditions seen in the office or clinic, including rhinitis and rhinosinusitis, allergic eye disease, asthma, urticaria and angioedema, atopic and contact dermatitis, drug allergy, food allergy, anaphylaxis, and stinging insect allergy. "Cross-talk" between chapters helps show the interrelationships among the various allergic disorders. The chapters begin with a review of pathophysiologic mechanisms and then consider a clinically structured approach to diagnosis and management of the disorders. In addition to pharmacologic treatment, the importance of nonpharmacologic management and patient education is emphasized. At the end of each chapter, clinical vignettes highlight the daily management of the allergic patient. Clinical Allergy: Diagnosis and Management, provides a logical framework for the evaluation and management of allergic disorders in patients.
Author: Tina Rich
Publisher: Springer Science & Business Media
ISBN: 0387274456
Category : Science
Languages : en
Pages : 227
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Book Description
Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. ^ Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ ing it as a ^^MddchenfUr alles," (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to reveal. Toll-Like Receptor (TLR) biology would prove to be one of these secrets. Analyses of the evolution of these receptors (Tolls and TLRs) have also helped us to rethink immune system phylogeny. In the first part of this chapter the history of the discovery of Toll and TLR biology is described. The evolution of the TLR genes and theories of immune function are covered in later sections. The remainder of this book presents work from nine groups active in the field. In the first chapter, "The Function of Toll-Like Receptors", Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors. Zlatko finishes his chapter with a discussion about current immune system models and contributes his own 'integrity model'. Work from the laboratory of Nicholas Gay follows this in "Structures and Motifs Involved in Toll Signaling".
Author: Malak Kotb
Publisher: Springer Science & Business Media
ISBN: 1592593097
Category : Medical
Languages : en
Pages : 425
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Book Description
A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.
Author: Eyal Raz
Publisher: Springer Science & Business Media
ISBN: 3642468675
Category : Medical
Languages : en
Pages : 182
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Book Description
Vaccination has been established as an efficient procedure to prevent infections. Over the past few years, a new method of subunit vaccination has attracted the attention of immunologists. Despite its popularity, it is only recently that the basic mechanisms that drive the immune response to the encoded antigen have begun to unfold. The multidisciplinary approach of this book outlines the basic characteristics of gene (DNA) vaccination, the role of APCs or bone marrow derived cells in the induction of the immune response. It points out the potential applications for various infectious and allergic diseases and describes the multifaceted properties of DNA in initiating and determining the subsequent immune responses to the encoded antigen.
Author: N. Franklin Adkinson Jr.
Publisher: Elsevier Health Sciences
ISBN: 0323076815
Category : Medical
Languages : en
Pages : 1876
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Book Description
This best-selling resource has a worldwide reputation as the leader in its field. Focusing on human immunology and biology, while also reporting on scientific experimentation and advancement, it provides comprehensive coverage of state-of-the-art basic science as well as authoritative guidance on the practical aspects of day-to-day diagnosis and management. This new edition includes 700 full-color illustrations and a new, more accessible format to make finding information a snap for the busy practitioner. And this Expert Consult Edition offers online access to the complete contents of the 2-volume set, fully searchable, and much more. Includes a glossary of allergy and immunology for quick and easy reference. Contains keypoints and clinical pearls highlighted to find important information quickly. links to useful online resources both for you and for your patients. Offers contributions from hundreds of international authorities for world-class expertise in overcoming any clinical challenge. Contains 400 new illustrations, 700 in all, to better illustrate complex immunology. Covers the very latest in the field, including hot topics such as food allergy and immunotherapy. Includes the latest guidelines from The National Asthma Education and Prevention Program (NAEPP). Utilizes a new, more user-friendly full-color format for easier reference. Includes online access to the entire contents of the book, fully searchable, with links to MEDLINE abstracts for all of the references.
