Immunobiology and Immunopharmacology of Bacterial Endotoxins PDF Download
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Author: A. Szentivanyi
Publisher: Springer Science & Business Media
ISBN: 1461322537
Category : Medical
Languages : en
Pages : 499
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Book Description
Endotoxins are constituents of all gram negative bacteria, as well as many other microorganisms. Since their original discovery and study at the beginning and middle parts of this century, many investigations have been performed concerning their immunochemistry and physicochemistry, as well as their pharmacologic activities and physiologic effects on the host. It became widely recognized during the beginning of this century that the pyrogenicity of many microbial infections may be associated with endotoxins. Furthermore, some 80 years ago, attempts were begun to "treat" a variety of illnesses including neoplasia, with such "pyrogens", Le. , bacterial endo toxins. Inconclusive results were observed including some detrimental ones as well as, in some cases, beneficial ones. It became widely accepted that during infections with many gram negative organisms the fever occurring in patients, as well as many of the untoward pathophysiological effects of the infections, seemed to be due to the endotoxin the bacteria contained or released. In this regard, septic shock has been studied in detail by many clinicians, physiologists and pharmacologists and attempts have been made to relate the devastating effects of infection on metabolic and physiologic alterations caused by endotoxins. Recently, however, many beneficial effects of endotoxin have also been studied.
Author: A. Szentivanyi
Publisher: Springer Science & Business Media
ISBN: 1461322537
Category : Medical
Languages : en
Pages : 499
Get Book Here
Book Description
Endotoxins are constituents of all gram negative bacteria, as well as many other microorganisms. Since their original discovery and study at the beginning and middle parts of this century, many investigations have been performed concerning their immunochemistry and physicochemistry, as well as their pharmacologic activities and physiologic effects on the host. It became widely recognized during the beginning of this century that the pyrogenicity of many microbial infections may be associated with endotoxins. Furthermore, some 80 years ago, attempts were begun to "treat" a variety of illnesses including neoplasia, with such "pyrogens", Le. , bacterial endo toxins. Inconclusive results were observed including some detrimental ones as well as, in some cases, beneficial ones. It became widely accepted that during infections with many gram negative organisms the fever occurring in patients, as well as many of the untoward pathophysiological effects of the infections, seemed to be due to the endotoxin the bacteria contained or released. In this regard, septic shock has been studied in detail by many clinicians, physiologists and pharmacologists and attempts have been made to relate the devastating effects of infection on metabolic and physiologic alterations caused by endotoxins. Recently, however, many beneficial effects of endotoxin have also been studied.
Author: H. Friedman
Publisher: Springer Science & Business Media
ISBN: 1475751400
Category : Medical
Languages : en
Pages : 689
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Book Description
This volume is based on the proceedings of the International Symposium on Bacterial Endotoxins held in Japan. May 11-14. 1988 and sponsored by the International Endotoxin Society and the International Society for Immuno pharmacology. Speakers and participants of this symposium provided new information concerning fundamental and clinical aspects of endotoxin research conducted over the last half decade or so. Advances have been made in understanding the structure and nature of endotoxin molecules and their effects on a wide variety of both cellular and subcellular aspects, of immunity. metabolism and physiology. both in vivo and in vitro. Endotoxins are constituents of gram negative bacteria. Since their original discovery in the nineteenth century. many laboratories studied their chemical composition. their physico- and immunochemica1 properties. as well as their pharmacological and physiological effects on the host. Much is now known about the chemical structure of the endotoxins. There is also a grow ing body of information concerning the multiple effects of endotoxins on the host including immune mechanisms. Some effects have been found to be benefi cial to the host and endotoxins are being used more frequently to induce important mediators of immunity as well as increasing resistance against infections by many microorganisms as well as inhibiting growth of tumors in experimental animal models and in man.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1028
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Book Description
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1712
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Book Description
First multi-year cumulation covers six years: 1965-70.
Author: Helmut Brade
Publisher: CRC Press
ISBN: 1000110389
Category : Science
Languages : en
Pages : 968
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Book Description
Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.
Author: Max Sussman
Publisher: Cambridge University Press
ISBN: 9780521453615
Category : Medical
Languages : en
Pages : 664
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Book Description
This topical compilation surveys the role of Escherichia coli in health and disease, including food poisoning.
Author: David C. Morrison
Publisher: CRC Press
ISBN: 9780849367885
Category : Science
Languages : en
Pages : 484
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Book Description
Bacterial Endotoxic Lipopolysaccharides provides an up-to-date, two-volume review of the latest information regarding bacterial lipopolysaccharide structure and activities. These volumes cover the biochemistry, pharmacology, and pathophysiologic properties of endotoxins. The volumes also thoroughly discuss the strengths and weaknesses of new therapies for septic shock that are based on an immunological attack on endotoxins and the cytokines induced by endotoxins. All scientists involved in endotoxin research, clinical infectious disease specialists, and medical students interested in the pathogenesis of septic shock will find Bacterial Endotoxic Lipopolysaccharides invaluable as a reference resource.
Author: Robert Ader
Publisher: Academic Press
ISBN: 1483258904
Category : Medical
Languages : en
Pages : 1263
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Book Description
Psychoneuroimmunology, Second Edition presents reports on the relationship between the nervous and immune systems. The book is divided into four sections. The first section details the role of neural structures and neurotransmitter signals in communication with the immune system. It documents the extensive neural connections with organs of the immune system; the dynamics of noradrenergic sympathetic innervation of spleen and thymus; and the evidence for immune signaling of the CNS. Part II elaborates the role of hormones in the modulation of immune functions; the basis for bidirectional communication between the neuroendocrine and immune systems; and the potential physiological implications of these neuroendocrine-immune system interactions. The third part addresses behavioral influences on immune response; the effects of conditioning, stress and social interactions in modulating immune responses; and the behavioral consequences of experimentally altered or genetically determined immunologic states. The final section presents the effects of psychosocial factors on immune responses and the potential impact of behavioral interventions in modulating immunity in healthy human subjects and in patients with AIDS. Neuroscientists, endocrinologists, and immunologists will find the book interesting.
Author: Steven Specter
Publisher: Springer Science & Business Media
ISBN: 1468455834
Category : Medical
Languages : en
Pages : 486
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Book Description
It is now widely acknowledged that at the beginning of this century Claude von Pirquet first pointed out that a viral disease, i. e. , measles, resulted in an anergy or depression of preexisting immune response, namely, delayed continuous hypersensitivity to PPD derived from Mycobacterium tuberculosis. Thereafter ob servations that viral infections may result in immunosuppression have been recorded by many clinicians and infectious disease investigators for six or seven decades. Nevertheless, despite sporadic reports that infectious diseases caused by viruses may result in either transient or prolonged immunodepression, investigation of this phenomenon languished until the mid-1960s, when it was pointed out that a number of experimental retroviral infections of mice with tumor viruses may result in marked immunosuppression. However, it was not until the recognition of the new epidemic of acquired immunodeficiency syn drome (AIDS) caused by the human immunodeficiency virus and related vi ruses that acquired immunodeficiencies associated with virus infection became general knowledge among biomedical investigators as well as the lay public. A number of reviews published during the past decade or so pointed out that numerous viruses may affect humoral and cellular immune responses. Furthermore, expanding knowledge about the nature and mechanisms of both humoral and cellular immunity and pathogenesis of viral infections has pro vided clinical and experimental models for investigating in depth how and why viruses of man and animals profoundly affect immune responses.
Author: Dale R. Spriggs
Publisher: CRC Press
ISBN: 9780849357190
Category : Medical
Languages : en
Pages : 172
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Book Description
Topics in Vaccine Adjuvant Research provides a concise, focused review of the immunological basis of adjuvant activity. The first section of the book contains several chapters that discuss key issues in cellular immunology, such as antigen processing and presentation, cytokine regulation of immune responses, and mucosal immunology. The second section consists of brief chapters on the mechanism of action of several adjuvants, including IL-2, nonionic block polymers, and cholera toxin. The major goals of this book are to define what is known about the mechanisms of adjuvant activity, show how research in cellular immunology can be used to help understand adjuvant action, and define possible areas where adjuvants might be useful probes for dissecting basic immunological processes. Immunologists, microbiologists, and infectious disease researchers will find this book an invaluable addition to their reference library.
