Identification of Mouse Mammary Tumor Virus-like Sequences in Human Breast Cancer PDF Download
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Author: Yue Wang
Publisher:
ISBN:
Category :
Languages : en
Pages : 109
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Book Description
Author: Yue Wang
Publisher:
ISBN:
Category :
Languages : en
Pages : 109
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Book Description
Author: Shunzo Chiba
Publisher: Springer Science & Business Media
ISBN: 3709165539
Category : Medical
Languages : en
Pages : 301
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Book Description
Recently, rapid developments have occurred in the field of viral gastroenteritis. This book is an update of fundamental and practical aspects of viral gastroenteritis. Among the various agents that cause viral gastroenteritis, group A rotaviruses and caliciviruses are the focus of this volume because of their clinical impact and the significance of new findings about them.
Author: Hong Yin
Publisher:
ISBN: 9789155444372
Category : Health & Fitness
Languages : en
Pages : 50
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Book Description
Author: Moulay Mustapha Ennaji
Publisher: Academic Press
ISBN: 0128149671
Category : Science
Languages : en
Pages : 388
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Book Description
Emerging and Reemerging Viral Pathogens: Applied Virology Approaches Related to Human, Animal and Environmental Pathogens, Volume Two presents new research information on viruses and their impact on the scientific community. It provides a reference book on certain viruses in humans, animals and vegetal, along with a comprehensive discussion on interspecies interactions. The book then looks at the drug, vaccine and bioinformatical strategies that can be used against these viruses, giving the reader a clear understanding of transmission. The book's end goal is to create awareness that the appearance of newly transmissible pathogens is a global risk that requires shared/adoptable policies for prevention and control. Covers most emerging viral disease in humans, animals and plants Provides the most advanced tools and techniques in molecular virology and the modeling of viruses Creates awareness that the appearance of new transmissible pathogens is a global risk Highlights the need to adopt shared policies for the prevention and control of infectious diseases
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
The purpose of this project was to search for mutations that affect susceptibility to breast cancer by screening the progeny of specially-bred mice. The male parent in each case had been treated with ethylnitrosourea (ENU) in the hope of inducing mutations. The female parent was homozygous for the c-neu oncogene under the control of the mouse mammary tumor virus (MMTV) promoter. In previous experiments, female mice that carry the MMTV-neu gene expressed a very high frequency of breast cancer after pregnancy and lactation, which are known to activate the MMTV-neu oncogene. After screening the progeny of 68 treated males, no mutations that affect breast cancer were identified, although mutations that affected other organ systems occurred. However, the major finding of the study was related to one of the control strains. The MN-lO strain carries the MMTV-neu oncogene on the BALB background and had previously demonstrated fairly high susceptibility to breast cancer at our institution. In the current project, its breast cancer rate was very low, and we believe this can be attributed to changes in animal care conditions that occurred since the previous work. The significance of this study was the identification of an ideal mouse model for studying environmental effects on spontaneous mammary tumors.
Author: Edward Robert Medeiros
Publisher:
ISBN:
Category : Mice
Languages : en
Pages : 370
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Author: Peter K. Vogt
Publisher: Springer Science & Business Media
ISBN: 3642747000
Category : Medical
Languages : en
Pages : 139
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Book Description
The newest volume in the Current Topics in Microbiology and Immunology series edited by Dr. Vogt and dealing with oncogenes and retroviruses contains four review articles by international authorities in the field. These articles presenting the latest research results continue the tradition of excellence for which the series is so well known.
Author: Judith Ann St. George
Publisher:
ISBN:
Category :
Languages : en
Pages : 204
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Book Description
Author: P. K. Vogt
Publisher:
ISBN: 9783642693588
Category :
Languages : en
Pages : 116
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Author: Deepa Shankar
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Mouse mammary tumor virus (MMTV) is used as an insertion mutagen in transgenic mice that express the Wnt1 gene in their mammary gland, to produce additional events like activation of a second oncogene. Cloning cellular sequences flanking new proviral insertion from tumor 76 identified a common insertion locus for MMTV. Further analyses of this region identified Fgf3 as the gene activated over a long distance by MMTV. Fgf8 is another oncogene that I identified was activated in 10% of the mammary tumors form these infected Wnt1 transgenic mice. Fgf8 encodes for at least seven different protein isoforms, three of which were isolated by us. These three isoforms (Fgf8a, b & c) differ in their NIH3T3 cell transforming abilities. Fgf8b induces programmed cell death of mammary epithelial cells. This apoptotic property is not confined to Fgf8b but is also seen when mammary epithelial cells are treated with purified human FGF proteins (FGF 1, 2, 4, 6, & 9). Over expression of BCL2 in the mammary epithelial cells delays the onset of FGF induced apoptosis. Female transgenic mice expressing the Fgf8 gene in the mammary gland developed tumors with a latency of 5-6 months. These tumors were found to be adenocarcinomas: benign adenomas to invasive ductal carcinomas. Northern analyses of tumor RNAs show high expression of the transgene.
