Author: Kainickal Cessal Thommachan
Publisher:
ISBN:
Category : Electronic books
Languages : en
Pages : 0
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Book Description
Head and neck squamous cell carcinomas arise from the mucosa of the upper aerodigestive tract and is often driven by risk factors like tobacco and alcohol consumption. Most of the time patients present with locally advanced stages and the outcome is poor, despite recent advances in multi-modality treatment. The epidemiology of the disease has changed over the last decade with the introduction of a separate clinical entity; Human Papillomavirus (HPV) associated head and neck cancer. The tumorigenesis is different from that of tobacco and alcohol-driven malignancies. These tumors have a better response to treatment owing to their inherent genetic makeup and carry an excellent prognosis. The current school of thought is to reduce the long-term morbidities associated with various treatment modalities, as these patients tend to survive longer. The best management of HPV-associated oropharyngeal cancer is under active investigation.
Author: Daniel L. Miller
Publisher: Springer
ISBN: 3319211005
Category : Medical
Languages : en
Pages : 316
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Book Description
Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries. In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection. Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity. This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume. This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem.
Author: Carole Fakhry
Publisher: Springer
ISBN: 8132224132
Category : Medical
Languages : en
Pages : 144
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Book Description
This book serves a snapshot of the current knowledge base in field. As human papillomavirus (HPV) causes a rising number of oropharyngeal cancers, understanding the biological, clinical and social implications of this infection has become increasingly important for head and neck practitioners. This book reflects the multidisciplinary nature of the scientific and clinical questions involved in this disease. Experts in epidemiology, diagnosis and treatment of HPV-related oropharyngeal cancer present in-depth reviews which will help to improve the reader’s understanding of this topic. The authors provide insight for answers of common patient and provider questions about HPV infection and related disease, and highlight remaining questions to be answered in the coming years.
Author: Wojciech Golusiński
Publisher: Springer
ISBN: 3319435809
Category : Medical
Languages : en
Pages : 257
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Book Description
This book is exceptional in presenting an interdisciplinary approach to the subject of human papillomavirus (HPV) infection in the context of head and neck cancer. Leading experts in the field discuss the epidemiology and molecular biology of HPV-positive head and neck squamous cell carcinoma, HPV testing, the nonsurgical and surgical treatment of HPV-positive tumors, predictive factors for outcome and quality of life, and ongoing trials on the effectiveness of vaccination in disease prevention. It also provides recommendations for testing, diagnosis treatment and vaccination. Otolaryngologists, head and neck surgeons, medical oncologists, radiation oncologists, molecular biologists and pathologists will find this book a valuable resource.
Author: Sara I Pai
Publisher: Elsevier Health Sciences
ISBN: 1455747459
Category : Medical
Languages : en
Pages : 200
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Book Description
HPV is a growing epidemic in head and neck cancer and specialists working with these diseases are provided information on shifting trends in HPV in head and neck cancers along with challenges and controversies in treating this disease. With this virus related cancer, there is a different approach to managing this patient population. Novel therapeutic treatments are actively being developed for this type of head and neck cancer. Topics include: Epidemioloygy of HPV-head and neck cancer; Clinical detection of HPV; Clinical evaluation and disease patterns of HPV-related head and neck cancers; Impact of HPV-related head and neck cancer in clinical trials; Molecular biology of HPV and head and neck cancer and targeted therapies; Transoral robotic surgery: new surgical techniques for oropharyngeal cancers; Economic impact of HPV-related cancers; Rehabilitation needs of oropharyngeal cancer patients; Psychosocial care needs of HPV-head and neck cancer patients; and a Multi-disciplinary approach to head and neck cancers.
Author: Adel K. El-Naggar
Publisher: IARC Who Classification of Tum
ISBN: 9789283224389
Category : Medical
Languages : en
Pages : 347
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Book Description
The WHO Classification of Head and Neck Tumours is the ninth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumors. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies evaluating response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. The book, prepared by 135 authors from 35 countries, contains more than 600 color images and tables, and more than 2700 references. This book is in the series commonly referred to as the "Blue Book" series.
Author: Eric M. Genden
Publisher: Thieme
ISBN: 163853229X
Category : Medical
Languages : en
Pages : 1553
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Book Description
Thieme congratulates Dr. Eric M. Genden on being chosen by New York magazine for its prestigious 'Best Doctors 2018' list! Head and Neck Cancer: Management and Reconstruction, 2nd Edition by Eric M. Genden masterfully blends two lauded Thieme books, Reconstruction of the Head and Neck, focusing on defect repair, and Head and Neck Cancer, a multidisciplinary, evidence-based approach to treatment. A significant increase in the incidence of oropharyngeal cancer in the U.S. and other countries, especially among men, is attributed to high-risk subtypes of the human papillomavirus (HPV). HPV associated tonsillar cancer and base of tongue cancer account for 90% of all oropharyngeal squamous cell carcinoma. Internationally renowned authors share the latest knowledge on HPV and other causes of head and neck cancers, from diagnosis to cutting-edge treatments. Thirty richly illustrated chapters feature open and endoscopic ablative techniques for treating a full spectrum of carcinomas and associated defects of the buccal, mandible and composite, laryngeal, hypopharyngeal, and parotid. The book encompasses the nuances of each pathology, step-by-step procedural guidance, clinical pearls, and the latest reconstructive techniques such as 3-D. For each disease, the authors discuss management concepts followed by principles of reconstruction and functional rehabilitation. Special topics include patient surveillance, monoclonal antibodies and immunotherapy, microvascular reconstruction, and minimizing wound complications. Key Features State-of-the-art management of carcinomas impacting the oral and nasal cavities, salivary glands, oropharynx, hypopharynx, larynx, thyroid, anterior skull base, skin, and more A chapter devoted to transoral robotic management of the oropharynx includes epidemiology, etiology, anatomy, staging, clinical presentation, diagnosis, work-up, and case studies More than 300 high-quality illustrations and photos elucidate complex anatomy and surgical approaches Concise videos posted online in the Thieme MediaCenter provide insightful hands-on surgical guidance This is the definitive, one-stop resource on the use of ablative and reconstructive approaches for head and neck cancers. Residents, fellows, and veteran practitioners in otolaryngology—head and neck surgery, radiation oncology, and medical oncology will benefit from this comprehensive reference.
Author: Jeffrey N. Myers
Publisher: Elsevier Health Sciences
ISBN: 0323186327
Category : Medical
Languages : en
Pages : 280
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Book Description
While cancers of the oral cavity and oropharynx were overwhelming found in smokers and drinkers, a dramatic shift is occurring with a dramatic rise in the incidence of HPV-associated oropharyngeal cancers while oral cavity cancers and HPV-negative oropharyngeal cancers appear to be declining in incidence, reflecting the reduction in cigarette smoking. These trends also have implications for how Otolaryngologists prevent, diagnose, workup, treat, and follow these patients. The focus of information in this issue is on oral cavity and oropharyngeal cancer and the implications of the HPV epidemic on this disease. Amongst the medical community during this period of trying to better grasp the association of HPV with oropharyngeal cancers, there are misconceptions and a lack of knowledge of these important shifts which are addressed by Guest Editors Jeffrey Myers and Erich Sturgis of the University of Texas, MD Anderson Cancer Center. Topics include: Epidemiology- Control of a tobacco epidemic? But emergence of a HPV epidemic?; Oral cavity and Oropharyngeal Cancer Genomics; Why Otolaryngologists need to be aware of Fanconi anemia; Impact on HPV on Orpharyngeal Cancer Biology and Response to Therapy-Implications for Treatment; Oral premalignancy- The roles of early detection and chemoprevention; Evaluation and staging- Limitations despite technological breakthroughs; 7) Surgical treatment innovations; Radiotherapy- The “Particle-rs of energy, dose, and delivery method; Systemic Treatment- Its role before, during, and after definitive treatment; How to maximize functional assessment/rehabilitation; Standardizing treatment for Cancers – An approach to cancer care or crisis?; Survivorship in Oral Cancer- Competing mortalities, morbidities, and second malignancies.
Author: Steven J Frank
Publisher: Elsevier Health Sciences
ISBN: 0323733506
Category : Medical
Languages : en
Pages : 422
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Book Description
As proton therapy treatment centers become smaller and more cost-effective, education and training for today’s multi-disciplinary oncology teams are more important than ever before. This state-of-the-art reference brings you fully up to date with all aspects of proton therapy, with guidance you can trust from MD Anderson Cancer Center, the largest and most experienced proton therapy center in the world. Led by Drs. Steven J. Frank and W. Ronald Zhu, Proton Therapy provides a unique opportunity to benefit from the unsurpassed knowledge and expertise of an esteemed team of leaders in the field. Covers all cancers for which proton therapy is used most often, including prostate, head and neck, pediatrics, central nervous system, gastrointestinal, sarcomas, lungs, breast, lymphomas, and gynecologic cancers. Provides up-to-date information on radiobiology, treatment planning and quality assurance, indications for proton therapy, management approaches, and outcomes after proton therapy by disease site. Discusses technologic advances such as spot scanning and treatment planning systems for the management of solid tumors; radiobiology of proton therapy, including DNA damage and repair mechanisms and acute and late effects on normal tissues; and multifield optimized intensity-modulated proton therapy (MFO-IMPT) for optimizing the distribution of linear energy transfer (LET) of proton beams within target volumes and away from critical normal structures. Includes a special section on head and neck cases in the e-book that photographically illustrates the full cycle of proton therapy care.
Author: Xiaoying Zhou
Publisher: BoD – Books on Demand
ISBN: 1789852641
Category : Medical
Languages : en
Pages : 250
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Book Description
Pharynx - Diagnosis and Treatment provides scientific views from international experts on the latest studies and consensus in pharynx diseases, in particular pharyngeal tumors, including oropharyngeal carcinoma, nasopharyngeal carcinoma, hypopharyngeal carcinoma, and others. The book also addresses non-tumoral pharyngeal diseases such as nasopharyngeal angiofibroma and obstructive sleep apnea. The chapters present guidelines and standards commonly used in clinics for the pharynx diseases mentioned, as well as new updates covering recent scientific findings and translational research on the approaches of diagnosis and treatment.
