Host Cell Factors Involved in Retrovirus Replication and Disease Pathogenesis PDF Download
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Author: Shannon Beth Seidel
Publisher:
ISBN: 9781267470218
Category :
Languages : en
Pages : 143
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Book Description
Retroviruses are relevant human pathogens affecting the lives of tens of millions of people globally each year and resulting in nearly 2 million deaths annually. Understanding the process of retrovirus infection has wide benefits including the identification of therapeutic targets to treat HIV/AIDS and better understanding of cellular pathways disrupted in diseases, such as cancer and AIDS. Here, I first present my role in a collaborative project that led to the identification of over 200 cellular factors with potentially important roles in the early stages of retrovirus infection. We identified these factors through a genome-wide siRNA screen and through characterization of interactions between host and virus proteins. Additionally, I present my work on ZASC1, a host cell transcription factor that binds to the promoter regions of both HIV-1 and MLV and regulates virus gene expression in cultured established cell lines. I generated a ZASC1 knockout mouse model, showing that this gene is non-essential to development and reproduction. This mouse model was used to characterize the role of ZASC1 in retrovirus replication and disease pathogenesis. I showed that ZASC1 influences myeloid cell differentiation in this compartment and that this transcription factor is required for efficient early Mo-MuLV infection in the bone marrow compartment. Through studies of Mo-MuLV pathogenesis in the ZASC1 knockout mouse model, I show that despite this early defect, tumorigenesis is not regulated by ZASC1.
Author: Shannon Beth Seidel
Publisher:
ISBN: 9781267470218
Category :
Languages : en
Pages : 143
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Book Description
Retroviruses are relevant human pathogens affecting the lives of tens of millions of people globally each year and resulting in nearly 2 million deaths annually. Understanding the process of retrovirus infection has wide benefits including the identification of therapeutic targets to treat HIV/AIDS and better understanding of cellular pathways disrupted in diseases, such as cancer and AIDS. Here, I first present my role in a collaborative project that led to the identification of over 200 cellular factors with potentially important roles in the early stages of retrovirus infection. We identified these factors through a genome-wide siRNA screen and through characterization of interactions between host and virus proteins. Additionally, I present my work on ZASC1, a host cell transcription factor that binds to the promoter regions of both HIV-1 and MLV and regulates virus gene expression in cultured established cell lines. I generated a ZASC1 knockout mouse model, showing that this gene is non-essential to development and reproduction. This mouse model was used to characterize the role of ZASC1 in retrovirus replication and disease pathogenesis. I showed that ZASC1 influences myeloid cell differentiation in this compartment and that this transcription factor is required for efficient early Mo-MuLV infection in the bone marrow compartment. Through studies of Mo-MuLV pathogenesis in the ZASC1 knockout mouse model, I show that despite this early defect, tumorigenesis is not regulated by ZASC1.
Author: Bryan Cullen
Publisher: Oxford University Press
ISBN: 9780199633821
Category : Gene Expression Regulation.
Languages : en
Pages : 220
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Book Description
The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Author: John A.T. Young
Publisher: Springer Science & Business Media
ISBN: 364219012X
Category : Medical
Languages : en
Pages : 250
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Book Description
The articles in this volume provide a comprehensive overview of our current understanding of the roles played by cellular factors in the early steps of retroviral replication. A better understanding of these functions will provide critical new insights into retrovirus-host cell interactions and is likely to prove useful for the future development of effective antiretroviral therapies.
Author: Henry Puerta-Guardo
Publisher: BoD – Books on Demand
ISBN: 085466467X
Category : Medical
Languages : en
Pages : 170
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Book Description
Viruses pose a huge burden on public health systems and the economy worldwide. In the case of humans, viruses make up about two-thirds of all new human pathogens. Both DNA and RNA viruses can cause acute, persistent, or latent infections, as they can integrate their genome into the host DNA, such as the endogenous retroviruses, which can be associated with a wide variety of cancers in animals and humans. In recent years, viruses have emerged not only as a health threat but also as a potential alternative for producing new diagnostic tools as well as prophylactic/therapeutic approaches to defeat viral diseases. This book provides a broadly comprehensive series of reviews describing the replication strategies used for both DNA and RNA viruses, their interaction with the host immune system, and their potential role in tumorigenicity and cancer immunotherapy as applied to various viruses of critical relevance for human or animal diseases.
Author: Reinhard Kurth
Publisher:
ISBN: 9781912530977
Category :
Languages : en
Pages :
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Book Description
Author: A. M. L. Lever
Publisher: World Scientific
ISBN: 9814295302
Category : Science
Languages : en
Pages : 502
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Book Description
There are three major types of human retroviruses, namely HIV, HTLV, and endogenous human retroviruses. This book presents the latest findings on the replication of these human retroviruses. This book is unique in that there has been no comparable book that integrates the findings from the three known classes of human retroviruses. Other books have focused on one of the three classes of human retroviruses individually. An accomplished international team of contributing authors have combined their expertise to provide cutting-edge findings in this important field. The book will be a valuable reference for students, researchers and medical professionals.
Author: Leslie Parent
Publisher: Academic Press
ISBN: 0128111933
Category : Science
Languages : en
Pages : 622
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Book Description
Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics Features important commonalities and differences among retroviral systems
Author: John A T Young
Publisher:
ISBN: 9783642190131
Category :
Languages : en
Pages : 256
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Book Description
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Christopher J. Burrell
Publisher: Academic Press
ISBN: 0123751578
Category : Science
Languages : en
Pages : 604
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Book Description
Fenner and White's Medical Virology, Fifth Edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health practice, scholarly research, and other endeavors. The book presents detailed exposition on the properties of viruses, how viruses replicate, and how viruses cause disease. These chapters are then followed by an overview of the principles of diagnosis, epidemiology, and how virus infections can be controlled. The first section concludes with a discussion on emergence and attempts to predict the next major public health challenges. These form a guide for delving into the specific diseases of interest to the reader as described in Part II. This lucid and concise, yet comprehensive, text is admirably suited to the needs of not only advanced students of science and medicine, but also postgraduate students, teachers, and research workers in all areas of virology. Features updated and expanded coverage of pathogenesis and immunity Contains the latest laboratory diagnostic methods Provides insights into clinical features of human viral disease, vaccines, chemotherapy, epidemiology, and control
