Genetics of Colorectal Cancer PDF Download
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Author: John D. Potter
Publisher: Springer
ISBN: 9780387095677
Category : Medical
Languages : en
Pages : 309
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Book Description
Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.
Author: John D. Potter
Publisher: Springer
ISBN: 9780387095677
Category : Medical
Languages : en
Pages : 309
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Book Description
Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.
Author: Miguel A. Rodriguez-Bigas
Publisher: Springer Science & Business Media
ISBN: 144196603X
Category : Medical
Languages : en
Pages : 615
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Book Description
Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.
Author: Lauri A. Aaltonen
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 320
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Book Description
An authoritative guide to the histological and genetic typing of human tumours of the digestive system. Prepared by 113 experts from 17 countries, the book covers neoplasms of the entire gastrointestinal tract, liver, biliary system, and exocrine pancreas. In view of their increasingly recognized importance, inherited tumour syndromes involving the digestive system are also described. Over 2200 references are included in this authoritative international tool. The book is organized according to ten groups of tumours. Each tumour is introduced with a concise definition and discussion of nomencl.
Author: B.A. Ponder
Publisher: Springer Science & Business Media
ISBN: 9401106770
Category : Medical
Languages : en
Pages : 222
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Book Description
It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.
Author: Nereo Segnan
Publisher:
ISBN:
Category : Colon (Anatomy)
Languages : en
Pages : 452
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Book Description
Recoge: 1. Introduction -- 2. Organisation -- Guiding principles for organising a colorectal cancer screening programme -- 3. Evaluation and interpretation of screening outcomes -- 4. Faecal occult blood testing -- 5. Quality assurance in endoscopy in colorectal cancer screening and diagnosis -- 6. Professional requirements and training -- 7. Quality assurance in pathology in colorectal cancer screening and diagnosis -- 8. Management of lesions detected in colorectal cancer screening -- 9. Colonoscopic surveillance following adenoma removal --10. Communication -- Appendices.
Author: Scott R. Steele
Publisher: Springer
ISBN: 3319259709
Category : Medical
Languages : en
Pages : 1269
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Book Description
This third edition text provides a completely revised and updated new version of this unique, modern, practical text that covers the strategic evaluation, specific approaches, and detailed management techniques utilized by expert colorectal surgeons caring for patients with complex problems–whether they result from underlying colorectal disease or from complications arising from previous surgical therapy. The format follows that of both a “how to” manual as well as an algorithm-based guide to allow the reader to understand the thought process behind the proposed treatment strategy. By making use of evidence-based recommendations, each chapter includes not only background information and diagnostic/therapeutic guidelines, but also provides a narrative by the author on his/her operative technical details and perioperative “tips and tricks” that they utilize in the management of these complex surgical challenges. Distinctive to this book, is the reliance on experts in the field including past presidents of the ASCRS, as well as multiple other national and internationally recognized surgeons, to lend their personal insight into situations where data may be more sparse, but individual and collective experience is paramount to making sound decisions and thereby optimizing patient outcomes. The text includes chapters on the assessment of risk and methods utilized to minimize perioperative complications. In addition, it incorporates sections covering the medical and surgical therapies for abdominal, pelvic and anorectal disease. Moreover, the technical challenges of managing complications resulting from the original or subsequent operations is addressed. The underlying focus throughout the text is on providing pragmatic and understandable solutions that can be readily implemented by surgeons of varying experience to successfully treat complex colorectal problems. However, it also goes beyond the technical aspects of colorectal surgery and includes special sections highlighting the essence of a surgeon; covering aspects involving the medical-legal, ethical, and economic challenges confronting surgeons. Throughout the text, each author provides an ongoing narrative of his/her individual surgical techniques along with illustrations and diagrams to “personally” take the reader through the crucial steps of the procedure, and key points of patient care inherent to that topic. Additionally, where appropriate, links to online videos give the reader an up-front look into technical aspects of colorectal surgery.
Author: Hideyuki Ishida
Publisher: Springer
ISBN: 9811330506
Category : Medical
Languages : en
Pages : 142
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Book Description
This book examines the latest indications and techniques for various endoscopic and surgical colorectal cancer treatments, discussing not only on the standard lymph node dissection technique, but also on laparoscopic and robotic surgery. It particularly focuses on the treatment of rectal cancer, with chapters on radiation therapy and sphincter preservation, which is analyzed from Asian perspectives that differ from those of Western treatment. Further, it presents the results of combining chemotherapy and oral drugs, as well as the treatment of hereditary cancer using next-generation sequencing for genetic diagnosis. Edited by surgeons who have pioneered the research and treatment of colorectal cancer, Recent Advances in the Treatment of Colorectal Cancer presents extensive information for clinicians such as endoscopic surgeons, colorectal surgeons, as well as oncologists and researchers specializing in this field. Providing a foundation for new ideas, it enables advanced surgeons to further develop their skills and offers thought-provoking, instructive and informative reading for residents, students and medical staff.
Author: Perry J. Pickhardt
Publisher: Elsevier Health Sciences
ISBN: 1437719732
Category : Medical
Languages : en
Pages : 545
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Book Description
In CT Colonography, Perry Pickhardt and David Kim present techniques for quicker evaluation and diagnosis of colon cancer through the pioneering, specialty-changing imaging technique of virtual colonoscopy (VC). This combination of sophisticated X-rays and CT scans of the abdomen offers patients an alternative to colonoscopy that is cost effective and reduces the need for unnecessary polyp removal. Abundantly illustrated in full color, this pioneering book describes CT colonography from pathogenesis, staging and treatment through indications, technique, and interpretation for the most common pathologies. Covers principles, techniques, and interpretations for the most common pathologies in a logical, practical organization. Presents tips from the authors on setting up a VC practice to provide a personal, instructive guide. Provides over 1000 full-color, high-resolution anatomic images throughout for the clearest, most accurate picture of colorectal cancer, its natural history, and its diagnosis by VC. Focuses on images, with the text serving as context for the proper use and understanding of VC.
Author: Martin Keuchel
Publisher: Springer
ISBN: 3662440628
Category : Medical
Languages : en
Pages : 584
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Book Description
This book is simultaneously a superb atlas and a detailed guide to all aspects of video capsule endoscopy. History, technique, performance, reading, indications, contraindications, outcomes, complications and alternative methods are described systematically by a large panel of experts. In addition, the full range of small bowel diseases, from the common to the rare, are described and illustrated using a unique and exhaustive collection of capsule endoscopy images that are accompanied by corresponding images of enteroscopy, surgery, radiology and histology whenever possible. The newest technology of colon capsule endoscopy is included and exciting potential future developments are also considered. This book will be indispensable for all who use the technique or are considering establishing a video capsule endoscopy service.
Author: Antonio Russo
Publisher: Springer Nature
ISBN: 3030560511
Category : Medical
Languages : en
Pages : 1104
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Book Description
This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology. Providing a systematic overview of all types of solid tumors, including epidemiology and cancer prevention, genetic aspects of hereditary cancers, differential diagnosis, typical signs and symptoms, diagnostic strategies and staging, and treatment modalities, it also discusses new and innovative cancer treatments, particularly targeted therapy and immunotherapy. Expert commentaries at the end of each chapter highlight key points, offer insights, suggest further reading and discuss clinical application using case descriptions. This textbook is an invaluable, practice-oriented tool for medical students just beginning their clinical oncology studies, as well as for medical oncology residents and young professionals.
