Health Risk Assessment of Trichloroethylene (TCE) in California Drinking Water PDF Download
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Author:
Publisher:
ISBN:
Category : Drinking water
Languages : en
Pages : 306
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Book Description
Author:
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ISBN:
Category :
Languages : en
Pages : 297
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Book Description
Author:
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ISBN:
Category : Chlorofluoromethane
Languages : en
Pages : 192
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Book Description
Author:
Publisher:
ISBN:
Category : Drinking water
Languages : en
Pages : 226
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Author:
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ISBN:
Category : Carbon tetrachloride
Languages : en
Pages : 182
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Book Description
Author:
Publisher:
ISBN:
Category : Drinking water
Languages : en
Pages : 178
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Book Description
Author:
Publisher:
ISBN:
Category : Drinking water
Languages : en
Pages : 120
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Book Description
Author:
Publisher:
ISBN:
Category : Drinking water
Languages : en
Pages : 202
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Book Description
Author:
Publisher:
ISBN:
Category : Chlorofluoromethane
Languages : en
Pages : 184
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Book Description
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309102839
Category : Science
Languages : en
Pages : 449
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Book Description
Trichloroethylene is a chlorinated solvent widely used as a degreasing agent in industrial and manufacturing settings. It is also used as a chemical intermediate in making other chemicals and is a component of products such as typewriter correction fluid, paint removers, adhesives, and spot removers. In 2001, EPA issued a draft health risk assessment and proposed exposure standards for trichloroethylene. PA's Scientific Advisory Board (SAB) reviewed the draft and it was issued for public comment. A number of scientific issues were raised during the course of these reviews. Assessing the Human Health Risks of Trichloroethylene identifies and assesses the key scientific issues relevant to analyzing the human health risks of trichloroethylene, considering pertinent toxicologic, epidemiologic, population susceptibility, and other available information, including relevant published scientific literature, EPA's 2001 draft health risk assessment of trichloroethylene, scientific and technical comments received by EPA from public and private sources, and additional relevant information to be provided by the sponsoring agencies. This report highlights issues critical to the development of an objective, realistic, and scientifically balanced trichloroethylene health risk assessment. Guidance for hazard characterization of trichloroethylene is presented in Chapters 2 through 10. Chapter 2 provides guidance for evaluating large sets of epidemiologic data. In Chapter 3, the committee applies this guidance as an example in its evaluation of the epidemiologic data on trichloroethylene and kidney cancer, and this example should help guide evaluations of other cancer risks. Chapter 3 also assesses new information on the kidney toxicity of trichloroethylene and its metabolites and potential modes of action. Chapters 4, 5, 6, 7, and 8 evaluate the key issues regarding liver toxicity and cancer, reproductive and developmental toxicity, neurotoxicity, respiratory tract toxicity and cancer, and immunotoxicity, respectively. However, the committee's review focused on mode-of-action information to understand how trichloroethylene might affect certain processes differently in different species. Chapter 9 discusses susceptibility to trichloroethylene and its metabolites, and Chapter 10 describes important factors in considering trichloroethylene in mixtures. Physiologically based pharmacokinetic models are evaluated in Chapter 11, and guidance is provided on future directions for model development. Finally, Chapter 12 considers issues related to dose-response assessment and quantitative assessment of risk.
Author: Rhoda G.M. Wang
Publisher: CRC Press
ISBN: 100010494X
Category : Technology & Engineering
Languages : en
Pages : 543
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Book Description
This volume examines every potential means of exposure to water contaminants, provides in-depth discussions on toxicology, and explains up-to-date techniques for evaluating human health risk. It develops a methodology for assessing the cumulative absorbed dose of contaminants through all routes of exposure, including ingestion, inhalation and dermal. Federal and state efforts to monitor and treat water are examined.
