Handbook of Clinical Pharmacokinetic Data PDF Download
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Author: David B. Jack
Publisher: Springer
ISBN: 1349224952
Category : Medical
Languages : en
Pages : 160
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Book Description
This compendium of essential drug data helps when planning clinical research projects and choosing drugs with specific properties. As well as covering established drugs, data is presented on compounds about to be marketed or in the last stages of clinical development.
Author: David B. Jack
Publisher: Springer
ISBN: 1349224952
Category : Medical
Languages : en
Pages : 160
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Book Description
This compendium of essential drug data helps when planning clinical research projects and choosing drugs with specific properties. As well as covering established drugs, data is presented on compounds about to be marketed or in the last stages of clinical development.
Author: Larry Bauer
Publisher: McGraw-Hill Medical
ISBN:
Category : Medical
Languages : en
Pages : 502
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Book Description
Designed for pharmacists and clinicians responsible for adjusting drug dosages based on the patient blood serum concentrations and other parameters, this indispensable, portable reference offers a variety of ways to perform pharmacokinetic calculations. Features calculation methods, algorithms for choosing the best calculation method, and case studies.
Author: L. F. Prescott
Publisher:
ISBN:
Category : Bioavailability
Languages : en
Pages : 1216
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Book Description
Author: Soraya Dhillon
Publisher: Pharmaceutical Press
ISBN: 9780853695714
Category : Chemotherapy
Languages : en
Pages : 284
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Book Description
Pharmacokinetics is the study of the process of drug absorption, distribution, metabolism and elimination. The aim of applying pharmacokinetic principles is to individualise the dose of drug, and optimise the outcome achieved in each patient. Its application reduces the chance of under-treatment, inadvertent poisoning, and dose related adverse effects. This new edition is specifically aimed at supporting undergraduate studies in pharmacokinetics, and has a strong emphasis on the application of pharmacokinetics in routine clinical practice. Clinical Pharmacokinetics also includes several case studies and 'questions and answers' to further aid understanding and revision.
Author: Younggil Kwon
Publisher: Springer Science & Business Media
ISBN: 0306468204
Category : Medical
Languages : en
Pages : 302
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Book Description
In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.
Author: Henry Cohen
Publisher: McGraw Hill Professional
ISBN: 0071832769
Category : Medical
Languages : en
Pages : 300
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Book Description
A STEP-BY-STEP APPROACH TO DESIGNING ACCURATE DOSING REGIMENS Casebook in Pharmacokinetics and Drug Dosing uses real-life cases to teach pharmacy students, pharmacists, and clinical pharmacists how to apply pharmacokinetics to formulate proper dosing regimens. In order to be as clinically relevant as possible, the book not only discusses drugs with readily available therapeutic serum levels, but places equal emphasis on high-alert agents with narrow therapeutic indexes. Each drug chapter is written by clinical pharmacists who have hands-on experience in drug dosing and includes an overview of the drug’s pharmacology, including: Indications Mec hanisms of action Toxicities Pharmacokinetics There is comprehensive review and discussion of each drug's bioavailability, volume of distribution, clearance, half-life, therapeutic drug level monitoring, drug interactions, dosing, and availability. Each chapter is enhanced by numerous patient cases with clear step-by-step answers and explanations. Calculations, equations, and dosing recommendations are provided for each case.
Author: Wolfgang A. Ritschel
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 616
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Book Description
Author: John E. Murphy
Publisher:
ISBN: 9781585285365
Category : Pharmacokinetics
Languages : en
Pages : 0
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Book Description
In the evolving practice of pharmacokinetics (PK), it is important to keep on top of the latest advances. John E. Murphy, a well-known leader in the field of clinical pharmacokinetics, has updated and expanded his widely-used textbook and reference. Clinical Pharmacokinetics, Sixth Edition includes the most current information, covering issues such as rational use of drug concentration measurements, changes in dosing obese patients, and considerations for a wider variety of drugs for special populations. There is also a new chapter focused on pharmacogenomics and its impact on pharmacokinetic parameters, as well as discussion of pharmacogenomics throughout the book. The new edition includes everything you need to know about pharmacokinetics today: Drugs, dosing, and therapeutic. Drug concentration measurements. New chapter on the impact of pharmacogenomics. Neonatal, pediatric, obese, and geriatric dosing. Dosing in renal disease and creatinine clearance estimation. Drugs sorted by family and as single drugs. Written in a straightforward style, with numerous charts and lists, the sixth edition makes complicated dosing and monitoring information easy to find and understand. Whether you are a student or practitioner, it is a resource you will turn to for reliable guidance throughout your pharmacy career.
Author: Michael W. Jann
Publisher: Springer
ISBN: 3319278835
Category : Medical
Languages : en
Pages : 597
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Book Description
This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together,or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result. The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology.Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions,isfrequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.
Author: M. Gibaldi
Publisher:
ISBN: 9780683100044
Category :
Languages : en
Pages : 1181
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Book Description
