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Author: John R. Samples
Publisher: Kugler Publications
ISBN: 9062998887
Category : Medical
Languages : en
Pages : 376
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Book Description
Foreword Volume 2 of our serial publication continues our desire to address glaucoma with a combination of science and speculation. As science expands, the emphasis is on data, interpretation, and dogma. We disagree; open minds open new approaches. Using methodologies that are primarily molecular and genetic, we seek to refine the causes of glaucoma as well as how it is best treated, especially incorporating thoughts and hypotheses about new methods of treatment. Glaucoma is a complex disease, and genetics proves that a variety of proteins are culpable at one level. At another level, however, there are likely final common pathways and numerous feedback loops which have defied explanations to date. The search for answers goes on in basic science researcher’s laboratories and clinical ophthalmologist’s offices and operating rooms. We are all well-served by understanding that glaucoma is a neurodegenerative disease. Current attempts to solve the disease have focused on two strategic arenas: the trabecular meshwork function and its impact on intraocular pressure as a major risk factor for the disease; and the optic nerve dysfunction leading to visual loss. Genetic mutations have yielded puzzling clues to the cause, but without resolution. For example, mutations in myocilin and optineurin genes are closely connected to the phenotype, but how do they cause the disease? In the next two years, priority areas of research are signaling pathway discoveries, biomarker panels, epigenetic factors, and continued genomic studies to yield answers to the common final pathways of the disease. The final pathways are complex and redundant, such that the overlap of bio-informatics will be challenging. Current promising leads suggest the innate immune system holds important clues to both trabecular meshwork and optic nerve pathophysiology. When the primary open-angle glaucoma disease pathways are unraveled, drug discoveries and new treatment modalities will be available for better regulation of intraocular pressure and neuroprotection for the optic nerve. This volume discusses the glaucoma pipeline from several perspectives as well as future candidate classes. As always, the authors herein are urged to speculate on how the cure of glaucomatous optic nerve damage will yield to new treatments. John R. Samples Clinical Professor, Elson S. Floyd College of Medicine, Washington State University School of Medicine www.glaucomaconcepts.com Paul A. Knepper Associate Professor of Ophthalmology, Feinberg School of Medicine, Northwestern University Medical School Research Scientist, University of Illinois at Chicago
Author: John R. Samples
Publisher: Kugler Publications
ISBN: 9062998887
Category : Medical
Languages : en
Pages : 376
Get Book Here
Book Description
Foreword Volume 2 of our serial publication continues our desire to address glaucoma with a combination of science and speculation. As science expands, the emphasis is on data, interpretation, and dogma. We disagree; open minds open new approaches. Using methodologies that are primarily molecular and genetic, we seek to refine the causes of glaucoma as well as how it is best treated, especially incorporating thoughts and hypotheses about new methods of treatment. Glaucoma is a complex disease, and genetics proves that a variety of proteins are culpable at one level. At another level, however, there are likely final common pathways and numerous feedback loops which have defied explanations to date. The search for answers goes on in basic science researcher’s laboratories and clinical ophthalmologist’s offices and operating rooms. We are all well-served by understanding that glaucoma is a neurodegenerative disease. Current attempts to solve the disease have focused on two strategic arenas: the trabecular meshwork function and its impact on intraocular pressure as a major risk factor for the disease; and the optic nerve dysfunction leading to visual loss. Genetic mutations have yielded puzzling clues to the cause, but without resolution. For example, mutations in myocilin and optineurin genes are closely connected to the phenotype, but how do they cause the disease? In the next two years, priority areas of research are signaling pathway discoveries, biomarker panels, epigenetic factors, and continued genomic studies to yield answers to the common final pathways of the disease. The final pathways are complex and redundant, such that the overlap of bio-informatics will be challenging. Current promising leads suggest the innate immune system holds important clues to both trabecular meshwork and optic nerve pathophysiology. When the primary open-angle glaucoma disease pathways are unraveled, drug discoveries and new treatment modalities will be available for better regulation of intraocular pressure and neuroprotection for the optic nerve. This volume discusses the glaucoma pipeline from several perspectives as well as future candidate classes. As always, the authors herein are urged to speculate on how the cure of glaucomatous optic nerve damage will yield to new treatments. John R. Samples Clinical Professor, Elson S. Floyd College of Medicine, Washington State University School of Medicine www.glaucomaconcepts.com Paul A. Knepper Associate Professor of Ophthalmology, Feinberg School of Medicine, Northwestern University Medical School Research Scientist, University of Illinois at Chicago
Author: P.A. Knepper
Publisher: Kugler Publications
ISBN: 9062999301
Category : Medical
Languages : en
Pages : 282
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Book Description
Author: P.A. Knepper
Publisher: Kugler Publications
ISBN: 9062992471
Category : Medical
Languages : en
Pages : 338
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Book Description
This first volume of the New Concepts in Glaucoma series was conceived as a platform to express new ideas and approaches to understanding and solving primary open-angle glaucoma. The authors have attempted to expand levels of knowledge, present new ideas and challenge existing theories. Although the authors have painted a broad picture, the central theme of the book is to ask the right questions and seek the answers for patients with primary open-angle glaucoma.
Author: Kevin Gillmann
Publisher: Elsevier
ISBN: 0323884431
Category : Science
Languages : en
Pages : 484
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Book Description
The Science of Glaucoma Management: From Translational Research to Next-Generation Clinical Practice bridges the gap between laboratory research and clinicians by bringing the latest promising research directly from researchers to clinicians long before they translate into clinical advances, and often before they are presented at conferences. Organized as a series of clinically relevant topics written by world-leading experts, this book summarizes the current state of laboratory and translational research and draws on the potential implications for day-to-day clinical practice. It offers new insights and mind-opening statements through contributions from some of the most respected glaucoma research groups. The book allows glaucoma specialists to explore novel ways to refine and rethink their practice based on the latest discoveries in basic sciences and breakthrough technologies, and to gain a better understanding on how their specialty is evolving and how research may shape tomorrow's practice. - Presents a detailed report on the latest translational research and breakthroughs that may transform glaucoma practice - Overviews the specialty from a scientific and clinical point-of-view - Written by world-renowned clinicians and researchers in the field of glaucoma - Includes insights, opinions and recommendations from some of the most prominent scientists and ophthalmologists - Covers hot topics and the latest technologies in glaucoma, such as minimally invasive glaucoma surgery, telemedicine, gene therapy, neuroprotection and artificial intelligence
Author: Tarek M. Shaarawy
Publisher: Elsevier Health Sciences
ISBN: 0702029769
Category : Medical
Languages : en
Pages : 1349
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Book Description
Recent dramatic advances in diagnosis, as well as medical and surgical treatment, mean that you can offer your glaucoma patients more timely and effective interventions. This brand-new clinical reference delivers the comprehensive, expert guidance you need to make optimal use of these new approaches.online, in print, and on video on DVD Get in-depth guidance on all aspects of adult and pediatric glaucoma with one volume devoted to diagnosis and medical treatment, and another that focuses on surgical techniques.
Author: Gyan Prakash
Publisher: Springer Nature
ISBN: 9811591849
Category : Medical
Languages : en
Pages : 478
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Book Description
This third volume, with three supporting editors, broadens its focus on genetic eye research from the Asian to the global scale. New efforts and a new awareness have sparked important discussions on genetic eye research, and new plans are being implemented to identify the genes responsible for numerous eye diseases. The book introduces the latest findings on genetics in eye diseases, gene therapy, and genome-wide association analysis, and the efforts of the Global Eye Genetic Consortium (GEGC). The book’s editors have been instrumental in developing strategies for discovering the new genes involved in many eye diseases. All chapters were written by leading researchers working on eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume III is a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases around the globe.
Author: Young H. Kwon
Publisher: Fep International
ISBN: 9780979707513
Category : Medical
Languages : en
Pages : 0
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Book Description
The Patient's Guide to Glaucoma is a very useful educational resource. The authors have done an excellent job of covering the pertinent aspects of glaucoma from the patient's perspective. It provides more complete explanations of aspects of glaucoma care than any other presently available resource. It will be very helpful to patients who want more information about medications, laser, trabeculectomy, tube-shunt surgery, and many other subjects. John S. Cohen, MD Director, Glaucoma Service Cincinnati Eye Institute, Volunteer Clinical Professor University of Cincinnati Drs. Kwon, Greenlee and Fingert are to be congratulated for creating this outstanding educational program on glaucoma. These materials provide an excellent overview of the disease and its treatment. The guide can be read in its entirety or searched to answer specific questions. It is aimed at the intelligent patient seeking to understand his or her disease. The ophthalmologist's best ally in battling glaucoma is a well-informed patient and this guide will serve to develop patients who truly understand their disease. W.L.M. Alward, MD The Frederick C. Blodi Chair in Ophthalmology, Professor of Ophthalmology, Vice-Chair, Dept of Ophthalmology & Visual Sciences, University of Iowa
Author: Malik Kahook
Publisher: CRC Press
ISBN: 9781617116001
Category : Medical
Languages : en
Pages : 0
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Book Description
With a revolution in the surgical management of mild to moderate glaucoma, new procedures allow for the use of microinvasive techniques that avoid disruption of the conjunctiva and formation of a bleb. These approaches range from laser therapies targeting the outflow system of the eye to the implantation of miniature devices in Schlemm's canal or the suprachoroidal space. The emergence of this new branch of glaucoma surgery, often coupled with micro-incisional cataract surgery, requires the practicing surgeon to learn about anatomical nuances to ensure success. MIGS: Advances in Glaucoma Surgery will aid the novice resident as well as the seasoned ophthalmic surgeon facing these new issues in glaucoma treatment. The book addresses preoperative patient selection advice, intraoperative pearls for success, and post operative management skills, which are some of the important aspects of the process towards the adoption of MIGS. Why you will want to read MIGS: Advances in Glaucoma Surgery: * Forward thinking contributions from seasoned MIGS experts who have intimate knowledge of the devices benefits and potential pitfalls in their use * Basic knowledge is provided that will allow each surgeon to tailor their treatment plan while leveling the learning curve * Assists in indentifying patients with a milder form of the disease and higher target pressures who may benefit from the MIGS devices MIGS: Advances in Glaucoma Surgery is the first book of its kind to cover the range of devices in this arena using expert contributors and offering real world pearls for practice that can be used in the operating room. Practicing cataract and glaucoma physicians, residents, and fellows will benefit from this timely resource as the thought process for how to treat glaucoma has advanced.
Author: J.R. Samples
Publisher: Kugler Publications
ISBN: 9062999077
Category : Medical
Languages : en
Pages : 327
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Book Description
Successful interventional glaucoma remains a sought-after goal for the glaucoma clinician for many reasons. Medical costs, compliance, and adherence remain major barriers for the treatment of our patients. A truly definitive treatment for glaucoma is most likely to be largely surgical, as it is doubtful that patients will continue to use glaucoma drugs in the future for anything other than transient lowering of intraocular pressure. In the coming era, it seems probable that neuroprotection and neurorestoration will be combined with MIGS to lower pressure. The different types of MIGS are increasing in proportion to their efficacy. To date, there are no fewer than 12 choices available to glaucoma specialists. Choice of procedure depends on the underlying anatomy as well as the patient’s individual characteristics. Truthfully, the number of available surgeries depends upon their taxonomy. Most are based on the outflow system and the canal, as illustrated in this book.
Author: Elizabeth Hodapp
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 226
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Book Description
This text provides a practical and expert problem-solving approach to the diagnosis and management of the glaucoma patient. The authors place emphasis on an approach to chronic, year-in, year-out care of the glaucoma patient - one of the most challenging management issues of the general ophthalmologists' practice. The first section of the book reviews the differential diagnosis of the patients who present with signs and symptoms suggestive of glaucoma, such as elevated pressure, abnormal optic nerve head, abnormal visual field and abnormal anterior chamber angle. The second section focuses on the chronic management of glaucoma. The authors describe the thought process/clinical decisions used to formulate and monitor treatment. In particular, they describe: how to determine the vigour with which to treat and monitor the individual patient; and how to determine if treatment is adequate and/or successful.
