Genetic Approaches to Studying Coronary Heart Disease in SR-BI/apoE Double Knockout Mice PDF Download
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Author: Sharon Liz Karackattu
Publisher:
ISBN:
Category :
Languages : en
Pages : 286
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Book Description
(cont.) This reduction in atherosclerosis is associated with delayed onset and/or progression of hypertrophy, myocardial infarction and cardiac dysfunction as well as a 37% extension in lifespan. Both of these studies, along with others, suggest SR-BI/apoE dKO mice experience atherosclerotic coronary-occlusion-induced ischemic heart disease and that they may be a valuable tool in which to investigate the etiology of as well as influences of genetic, environmental and pharmacologic manipulations on CHD.
Author: Sharon Liz Karackattu
Publisher:
ISBN:
Category :
Languages : en
Pages : 286
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Book Description
(cont.) This reduction in atherosclerosis is associated with delayed onset and/or progression of hypertrophy, myocardial infarction and cardiac dysfunction as well as a 37% extension in lifespan. Both of these studies, along with others, suggest SR-BI/apoE dKO mice experience atherosclerotic coronary-occlusion-induced ischemic heart disease and that they may be a valuable tool in which to investigate the etiology of as well as influences of genetic, environmental and pharmacologic manipulations on CHD.
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 886
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Book Description
Author: Arnold von Eckardstein
Publisher: Springer
ISBN: 9783319096643
Category : Medical
Languages : en
Pages : 0
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Book Description
In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.
Author: Sara L. Torres
Publisher:
ISBN:
Category : Disease susceptibility
Languages : en
Pages : 322
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Book Description
A genetic predisposition is a genetic effect which influences the phenotype of an organism but which can be modified by the environmental conditions. Genetic testing is able to identify individuals who are genetically predisposed to certain health problems such as cancer or other life altering diseases. This book discusses the determination of the genetic basis of health problems that will help the precise mechanisms of health problem such as a disease or physical disorder.
Author: Elena Aikawa
Publisher: BoD – Books on Demand
ISBN: 9535111507
Category : Medical
Languages : en
Pages : 544
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Book Description
Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.
Author: John Betteridge
Publisher: CRC Press
ISBN: 9780340552698
Category : Medical
Languages : en
Pages : 1328
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Book Description
This comprehensive work deals with the major health problem of high lipid levels in blood, a cause of serious heart and vascular disease. Formerly the province only of the chemical pathologist, cardiologists and general physicians are now offering treatment as new 'lipid-lowering' drugs become available. The area is also of considerable interest to public health physicians as changes in lifestyle (such as dietary and smoking habits) have significant effects on lipid levels. A prestigious team of contributors covers all aspects of the topic, from molecular biology to practical dietary management to help reduce lipid levels.
Author: Arnold von Eckardstein
Publisher: Springer Nature
ISBN: 3030860760
Category : Atherosclerosis
Languages : en
Pages : 537
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Book Description
This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs' reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets.
Author: Leonardo Pantoni
Publisher: Cambridge University Press
ISBN: 1107031664
Category : Medical
Languages : en
Pages : 375
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Book Description
Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.
Author: Georg Wick
Publisher: Springer Science & Business Media
ISBN: 370910338X
Category : Medical
Languages : en
Pages : 628
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Book Description
It has been known for over 150 years that hallmarks of inflammation can be observed in the wall of atherosclerotic vessels. It was, however, not clear if this inflammation is the cause or the consequence of atherogenesis. More recently, it has become evident that inflammation mediated both by innate and adaptive immunity is instrumental even in the earliest stages of the development of atherosclerotic lesions, i.e., that it plays an important pathogenetic role. In this volume, international experts in the field discuss the pathogenetic, diagnostic, preventive and possible therapeutic relevance of inflammation in atherogenesis. This book is intended for researchers and physicians in the fields of vascular biology, immunology and atherosclerosis.
Author: P. Michael Conn
Publisher: Academic Press
ISBN: 0124159125
Category : Science
Languages : en
Pages : 1109
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Book Description
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease
