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Author: Joselin Linder
Publisher: HarperCollins
ISBN: 0062378929
Category : Biography & Autobiography
Languages : en
Pages : 245
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Book Description
A riveting medical mystery about a young woman’s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicine When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.
Author: Joselin Linder
Publisher: HarperCollins
ISBN: 0062378929
Category : Biography & Autobiography
Languages : en
Pages : 245
Get Book Here
Book Description
A riveting medical mystery about a young woman’s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicine When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.
Author: M. Neale
Publisher: Springer Science & Business Media
ISBN: 9401580189
Category : Medical
Languages : en
Pages : 503
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Book Description
Few would dispute the truth of the statement `People are Different', but there is much controversy over why. This book authoritatively explains the methods used to understand human variation, and extends them far beyond the primary `nature or nurture' question. After chapters on basic statistics, biometrical genetics, matrix algebra and path analysis, there is a state-of-the-art account of how to fit genetic models using the LISREL package. The authors explain not only the assumptions of the twin method, but how to test them. The elementary model is expanded to cover sex limitation, sibling interaction, multivariate and longitudinal data, observer ratings, and twin-family studies. Throughout, the methods are illustrated by applications to diverse areas such as obesity, major depression, alcohol comsumption, delinquency, allergies, and common fears.
Author: Ziheng Yang
Publisher: Oxford University Press, USA
ISBN: 0198566999
Category : Medical
Languages : en
Pages : 374
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Book Description
This book describes the models, methods and algorithms that are most useful for analysing the ever-increasing supply of molecular sequence data, with a view to furthering our understanding of the evolution of genes and genomes.
Author: Joram Piatigorsky
Publisher: Harvard University Press
ISBN: 9780674023413
Category : Science
Languages : en
Pages : 434
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Book Description
In Gene Sharing and Evolution Piatigorsky explores the generality and implications of gene sharing throughout evolution and argues that most if not all proteins perform a variety of functions in the same and in different species, and that this is a fundamental necessity for evolution.
Author: Roger S Holmes
Publisher: World Scientific
ISBN: 9814548014
Category :
Languages : en
Pages : 234
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Book Description
Genes exist predominantly as families with related structures and functions, particularly within eucaryotic organisms. The isozyme concept was first introduced by Markert and MØller in 1959, and has formed the basis of large numbers of scientific investigations and conferences on gene families since that time. This volume is based on presentations made by invited Plenary and Symposia speakers at the Eighth International Congress on Isozymes on the topic of Gene Families: Structure, Function, Genetics and Evolution. The major themes for the Congress were in the following areas: molecular evolution; population genetics; enzymology; Australian fauna; biomedical aspects; molecular genetics; cellular compartmentation; gene regulation; and developmental genetics.
Author: Guoxiong Xue
Publisher: World Scientific
ISBN: 9789812810557
Category : Medical
Languages : en
Pages : 338
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Book Description
This archival volume is an invaluable collection of rigorously reviewed articles by experts in the fields of gene families, DNA, RNA and proteins, to commemorate the passing of a giant of science OCo Professor Clement L Markert (1917OCo1999). In 1959, Clement Markert and Freddy Moller developed the concept of the isozyme, which paved the way for extensive studies of enzyme, protein and gene multiplicity across all living organisms. This important scientific discovery has had a profound influence on the biological sciences for more than 40 years, and has provided the basis for regular international meetings to discuss the biological and biomedical implications of enzyme multiplicity. More recently, this concept has been extended to a wide range of gene families of DNA, RNA, proteins and enzymes. Contents: Clement Markert (G L Hammond); Identification of Novel Gene Family Members Based on Efficient Full-Length cDNA Cloning (J Gu et al.); Aldehyde Dehydrogenases of Human Corneal and Lens Epithelial Cells (R S Holmes); X-Chromosome Inactivation During Spermatogenesis: The Original Dosage Compensation Mechanism in Mammals? (J R Mc Carrey); Probing for the Basis of the Low Activity of the Oriental Variant of Liver Mitochondrial Aldehyde Dehydrogenase (B Wei & H Weiner); The Roles of Carbonic Anhydrase Isozymes in Cancer (W R Chegwidden et al.); MHC Class II Suppression by Trophoblast cDNAs (G L Hammond et al.); Molecular Information Fusion for Metabolic Networks (R Hofestndt et al.); Effect of Heterogeneous Sperm and Hybridization of DNA Fragment in Allogynogenetic Silver Crucian Carp (D Xia et al.); Gene Expression During Carrot Somatic Embryogenesis (N Wu); and other papers. Readership: Graduate students, post-docs and experts interested in gene families."
Author: Itai Yanai
Publisher: Harvard University Press
ISBN: 0674425022
Category : Science
Languages : en
Pages : 295
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Book Description
Nearly four decades ago Richard Dawkins published The Selfish Gene, famously reducing humans to “survival machines” whose sole purpose was to preserve “the selfish molecules known as genes.” How these selfish genes work together to construct the organism, however, remained a mystery. Standing atop a wealth of new research, The Society of Genes now provides a vision of how genes cooperate and compete in the struggle for life. Pioneers in the nascent field of systems biology, Itai Yanai and Martin Lercher present a compelling new framework to understand how the human genome evolved and why understanding the interactions among our genes shifts the basic paradigm of modern biology. Contrary to what Dawkins’s popular metaphor seems to imply, the genome is not made of individual genes that focus solely on their own survival. Instead, our genomes comprise a society of genes which, like human societies, is composed of members that form alliances and rivalries. In language accessible to lay readers, The Society of Genes uncovers genetic strategies of cooperation and competition at biological scales ranging from individual cells to entire species. It captures the way the genome works in cancer cells and Neanderthals, in sexual reproduction and the origin of life, always underscoring one critical point: that only by putting the interactions among genes at center stage can we appreciate the logic of life.
Author: Robert L. Nussbaum
Publisher:
ISBN: 9788131243145
Category :
Languages : en
Pages : 532
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Book Description
Updated to reflect the newest changes in genetics, Thompson & Thompson's Genetics in Medicine returns as one of the most favored texts in this fascinating and rapidly evolving field. By integrating the classic principles of human genetics with modern molecular genetics, this medical reference book utilizes a variety of learning tools to help you understand a wide range of genetic disorders. Acquire the state-of-the-art knowledge you need on the latest advances in molecular diagnostics, the Human Genome Project, pharmacogenetics, and bio-informatics. Better understand the relationship between basic genetics and clinical medicine with a variety of clinical case studies. Recognize a wide range of genetic disorders with visual guidance from more than 240 dynamic illustrations and high-quality photos.
Author: Gene Edward Veith Jr.
Publisher: Crossway
ISBN: 1433524090
Category : Religion
Languages : en
Pages : 258
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Book Description
What does it mean to be called as a husband, a wife, a parent, a child? How does the grace of the gospel impact how we carry out our particular calling? How does God's presence influence the struggles that families face? Gene Veith joins forces with his daughter Mary Moerbe to explore these kinds of questions as well as the roles of calling and vocation in family life. Though we have little control over who is in our family (other than choosing a spouse and deciding to have children), God has placed us with specific people for specific reasons. Veith and Moerbe show how our roles are distinct and important to God's plan for our lives—and that when we have a biblical understanding of those roles in our families, we can move away from common dysfunctions and toward forgiveness and healing. Writing with sensitivity and wisdom, Veith and Moerbe address the common problems facing contemporary families: the crosses, the weaknesses, and the uncertainties. They articulate a compelling, biblical paradigm for creating and sustaining loving and forgiving families who maintain hope in the face of cultural pressure. This book is an important resource for all Christians, including pastors, counselors, and those working in family ministry.
Author: Katharina Dittmar
Publisher: John Wiley & Sons
ISBN: 1118148096
Category : Science
Languages : en
Pages : 350
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Book Description
Gene duplication has long been believed to have played a major role in the rise of biological novelty through evolution of new function and gene expression patterns. The first book to examine gene duplication across all levels of biological organization, Evolution after Gene Duplication presents a comprehensive picture of the mechanistic process by which gene duplication may have played a role in generating biodiversity. Key Features: Explores comparative genomics, genome evolution studies and analysis of multi-gene families such as Hox, globins, olfactory receptors and MHC (immune system) A complete post-genome treatment of the topic originally covered by Ohno's 1970 classic, this volume extends coverage to include the fate of associated regulatory pathways Taps the significant increase in multi-gene family data that has resulted from comparative genomics Comprehensive coverage that includes opposing theoretical viewpoints, comparative genomics data, theoretical and empirical evidence and the role of bioinformatics in the study of gene duplication This up-to-date overview of theory and mathematical models along with practical examples is suitable for scientists across various levels of biology as well as instructors and graduate students.
