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Author:
Publisher: Elsevier
ISBN: 0080862152
Category : Medical
Languages : en
Pages : 561
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Book Description
GABA in the Retina and Central Visual System
Author:
Publisher: Elsevier
ISBN: 0080862152
Category : Medical
Languages : en
Pages : 561
Get Book Here
Book Description
GABA in the Retina and Central Visual System
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: Hubert Vaudry
Publisher: Springer Science & Business Media
ISBN: 9781402073069
Category : Medical
Languages : en
Pages : 432
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Book Description
Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.
Author:
Publisher:
ISBN:
Category : Retina
Languages : en
Pages : 408
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Book Description
Author: Josh Dubnau
Publisher: Cambridge University Press
ISBN: 1107009030
Category : Medical
Languages : en
Pages : 309
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Book Description
A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Author: Ron Douglas
Publisher: Springer Science & Business Media
ISBN: 9400904118
Category : Science
Languages : en
Pages : 531
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Book Description
A question often asked of those of us who work in the seemingly esoteric field of fish vision is, why? To some of us the answer seems obvious - how many other visual scientists get to dive in a tropical lagoon in the name of science and then are able to eat their subjects for dinner? However, there are better, or at least scientifically more acceptable, reasons for working on the visual system of fish. First, in terms of numbers, fish are by far the most important of all vertebrate classes, probably accounting for over half (c. 22 000 species) of all recognized vertebrate species (Nelson, 1984). Furthermore, many of these are of commercial importance. Secondly, if one of the research aims is to understand the human visual system, animals such as fish can tell us a great deal, since in many ways their visual systems, and specifically their eyes, are similar to our own. This is fortunate, since there are several techniques, such as intracellular retinal recording, which are vital to our understanding of the visual process, that cannot be performed routinely on primates. The cold blooded fish, on the other hand, is an ideal subject for such studies and much of what we know about, for example, the fundamentals of information processing in the retina is based on work carried out on fish (e. g. Svaetichin, 1953).
Author: William Benjamin Barkis
Publisher:
ISBN: 9781109368604
Category :
Languages : en
Pages : 55
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Book Description
Neural circuits rely on the interaction between excitation and inhibition to process information and require an appropriate balance between the two to avoid pathological consequences. Gamma-aminobutyric acid (GABA) is the principal neurotransmitter mediating inhibition in the adult central nervous system (CNS). However, during development GABAergic transmission is excitatory. Understanding the transition from excitatory to inhibitory GABA provides insight into the development of mature brain function as well as devising treatments for diseases involving imbalanced excitation and inhibition. A leading hypothesis is that neural activity plays a critical role in the transition from excitatory to inhibitory GABAergic transmission. Here I studied the role of neural activity in regulating the timing of the GABA switch in neurons in the ganglion cell layer of the mouse retina. I used three different knockout mice to demonstrate that the timing of the GABA switch is independent of nicotinic cholinergic activity, retinal waves, and glutamatergic activity. To further explore the role of activity in regulating the GABA switch, I developed a retinal explant model system in which neural activity could be pharmacologically manipulated. Blockade of GABA receptor-mediated activity did not prevent the transition from excitatory to inhibitory GABA, in contrast to previous observations in hippocampus and retina. Further, sustained blockade of glutamate receptors, GABA receptors, nicotinic acetylcholine receptors, glycine receptors, voltage-gated sodium channels, gap junctions, and L-type voltage-gated calcium channels (VGCCs) did not alter the transition. These results suggest that neuronal activity is not required for the transition from excitatory to inhibitory GABA in the mouse retina. To determine if the GABA switch is independent of signaling from other cell types, I cultured purified retinal ganglion cells (RGCs) in isolation. I found that purified RGCs did not develop an inhibitory response to GABA. These results indicate that unlike other parts of the nervous system, the transition from excitatory to inhibitory GABA signaling in mouse RGCs does not depend on activity but requires activity-independent signaling from another cell type.
Author: Robert Shapley
Publisher: MIT Press
ISBN: 9780262193399
Category : Contrast sensitivity (Vision)
Languages : en
Pages : 370
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Book Description
The seventeen contributions present current research in visual signal processing, in the retina and central pathways, and in the study of contrast sensitivity in humans. The seventeen contributions present current research in visual signal processing, in the retina and central pathways, and in the study of contrast sensitivity in humans.
Author: Evelyne Sernagor
Publisher: Cambridge University Press
ISBN: 1139459732
Category : Medical
Languages : en
Pages : 369
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Book Description
This advanced text, first published in 2006, takes a developmental approach to the presentation of our understanding of how vertebrates construct a retina. Written by experts in the field, each of the seventeen chapters covers a specific step in the process, focusing on the underlying molecular, cellular, and physiological mechanisms. There is also a special section on emerging technologies, including genomics, zebrafish genetics, and stem cell biology that are starting to yield important insights into retinal development. Primarily aimed at professionals, both biologists and clinicians working with the retina, this book provides a concise view of vertebrate retinal development. Since the retina is 'an approachable part of the brain', this book will also be attractive to all neuroscientists interested in development, as processes required to build this exquisitely organized system are ultimately relevant to all other parts of the central nervous system.
Author: Maria A. Patestas
Publisher: John Wiley & Sons
ISBN: 1118677358
Category : Medical
Languages : en
Pages : 544
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Book Description
Newly revised and updated, A Textbook of Neuroanatomy, Second Edition is a concise text designed to help students easily master the anatomy and basic physiology of the nervous system. Accessible and clear, the book highlights interrelationships between systems, structures, and the rest of the body as the chapters move through the various regions of the brain. Building on the solid foundation of the first edition, A Textbook of Neuroanatomy now includes two new chapters on the brainstem and reflexes, as well as dozens of new micrographs illustrating key structures. Throughout the book the clinical relevance of the material is emphasized through clinical cases, questions, and follow-up discussions in each chapter, motivating students to learn the information. A companion website is also available, featuring study aids and artwork from the book as PowerPoint slides. A Textbook of Neuroanatomy, Second Edition is an invaluable resource for students of general, clinical and behavioral neuroscience and neuroanatomy.
