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Author: James R. Lupski
Publisher: Springer Science & Business Media
ISBN: 1597450391
Category : Medical
Languages : en
Pages : 419
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Book Description
A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.
Author: James R. Lupski
Publisher: Springer Science & Business Media
ISBN: 1597450391
Category : Medical
Languages : en
Pages : 419
Get Book Here
Book Description
A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1900
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Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author: Aurora Ruiz-Herrera
Publisher: MDPI
ISBN: 3036501568
Category : Science
Languages : en
Pages : 248
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Book Description
Understanding of the origin of species and their adaptability to new environments is one of the main questions in biology. This is fueled by the ongoing debate on species concepts and facilitated by the availability of an unprecedented large number of genomic resources. Genomes are organized into chromosomes, where significant variations in number and morphology are observed among species due to large-scale structural variants such as inversions, translocations, fusions, and fissions. This genomic reshuffling provides, in the long term, new chromosomal forms on which natural selection can act upon, contributing to the origin of biodiversity. This book contains mainly articles, reviews, and an opinion piece that explore numerous aspects of genome plasticity among taxa that will help in understanding the dynamics of genome composition, the evolutionary relationships between species and, in the long run, speciation.
Author:
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Category : Genetics
Languages : en
Pages : 910
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Category : Cells
Languages : en
Pages : 450
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Book Description
Author: Stephen J. O'Brien
Publisher: John Wiley & Sons
ISBN: 0471779040
Category : Science
Languages : en
Pages : 544
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Book Description
A stunning visual collection of the banded metaphase chromosomekaryotypes from some 850 species of mammals, the Atlas of MammalianChromosomes represents an unabridged compendium of the state ofthis genomic art form. Bringing together information currentlyscattered throughout the cytogenetics literature for scores ofpublished and unpublished species, this atlas features high-qualitykaryotype images for nearly every mammal studied to date, making itthe most comprehensive assemblage of high-resolution chromosomephotographs available--a critically invaluable resource for today'scomparative genomics era. For every available species, the Atlas of Mammalian Chromosomespresents the best karyotype produced, the common and Latin name ofthe species, the published citation, and the contributing authors.Most karyotypes are G-banded, revealing the chromosomal bar codesof homologous segments among related species. Addressing the mandate of the Human Genome Project to annotate thegenomes of other organisms as well, the Atlas of MammalianChromosomes offers a step forward in our understanding of speciesformation, of genome organization, and of DNA script for naturalselection. It is an invaluable resource for geneticists,mammalogists, and biologists interested in comparative genomics,systematics, and chromosome structure.
Author: H. Leon Bradlow
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 532
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Book Description
In these proceedings for an October 2003 conference, contributors update topics and relevant issues in cancer research and clinical oncology, such as genetics, genomics, proteomics, signals and translational research in neuroectodermal timors, biomolecular surveying of cell signals, cell-to-cell communication, signals transduced by environmental and endogenous sex steroids, signals and molecular targets in human cancer tissues and cells, cell migration and adhesion, gene expression and silencing, and rational approaches to the design of therapeutics targeting molecular markers in hematologic malignancies. Topics of short papers include the induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors and a report from a registry comparing rates of breast cancer in the city and province of Palermo. Annotation ©2005 Book News, Inc., Portland, OR (booknews.com).
Author:
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ISBN:
Category : Medicine
Languages : en
Pages : 1218
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Author:
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Category : Animals
Languages : en
Pages : 1000
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Book Description
Author: Luca Sineo
Publisher: Firenze University Press
ISBN: 8884533856
Category : Science
Languages : en
Pages : 134
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Book Description
