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Author: Christina Bolander-Gouaille
Publisher: Springer Science & Business Media
ISBN: 2817808452
Category : Medical
Languages : en
Pages : 261
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Book Description
During the last 10-12 years, the research on homocysteine has become very active. About 1500 of articles are now published each year on homocysteine and the vitamins involved in its metabolism. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalised by treatment with folate and/or vitamines B12 and B6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialised journals. The author has realised the difficulties for the practitioner in keeping updated. This second edition has been thoroughly updated and also offers more data on the vitamins. Over 1600 references are made available.
Author: Christina Bolander-Gouaille
Publisher: Springer Science & Business Media
ISBN: 2817808452
Category : Medical
Languages : en
Pages : 261
Get Book Here
Book Description
During the last 10-12 years, the research on homocysteine has become very active. About 1500 of articles are now published each year on homocysteine and the vitamins involved in its metabolism. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalised by treatment with folate and/or vitamines B12 and B6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialised journals. The author has realised the difficulties for the practitioner in keeping updated. This second edition has been thoroughly updated and also offers more data on the vitamins. Over 1600 references are made available.
Author: Christina Bolander-Gouaille
Publisher: Springer Science & Business Media
ISBN: 2817807596
Category : Medical
Languages : en
Pages : 224
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Book Description
While research on homocysteine and vitamins involved in its metabolism has focused on associations with cardiovascular disease, pregnancy complications and fetal malformations, recent research explores connections between homocysteine metabolism and neuropsychiatric disease, particularly cognitive decline and dementia. If homocysteine-lowering vitamin treatment can reduce the incidence or delay the onset of dementia, the impact would be significant. This book summarises current research, reviews the underlying biochemistry and surveys diagnostic aspects.
Author: Christine Bolander-Gouaille
Publisher: Springer
ISBN: 2817807413
Category : Medical
Languages : en
Pages : 97
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Book Description
During the last 8-10 years the research on homocysteine has become very active. Hundreds of articles are now published each year. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalized by treatment with folate and/or vitamines B 12 and B 6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialized journals. The author has realized the difficulties for the practitioner in keeping updated.
Author: K. Robinson
Publisher: Springer Science & Business Media
ISBN: 9780792362487
Category : Medical
Languages : en
Pages : 480
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Book Description
This state-of-the-art review provides an in-depth and critical summary of homocysteine from its molecular basis to clinical relevance and current clinical trials of folic acid and vitamin B6. Written by leading workers in the field, the book provides an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians and any others engaged in the field. It will also be useful to anyone involved in managing vascular patients or cardiac risk factors, as well as biochemists, pharmacologists, general physicians, cardiologists and clinical and basic researchers with an interest in preventive medicine.
Author: Mostafa I. Waly
Publisher: Springer Nature
ISBN: 3030578399
Category : Medical
Languages : en
Pages : 274
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Book Description
Elevated blood concentrations of homocysteine, B vitamins deficiencies and oxidative stress are etiological factors for many human chronic diseases, yet the etiologic relationship of hyperhomocysteinemia to these disorders remains poorly understood. Clinical trials continue to support the notion that hyperhomocysteinemia is involved in the pathogenesis of oxidative stress and its associated impairment of cellular redox status. Antioxidants, phytochemicals, and bioactive agents are thought to be associated with the reduction of oxidative stress and reducing risk of chronic diseases, yet their role in preventing hyperhomocysteinemia-mediated oxidative stress has not been well covered in the literature. Nutritional Management and Metabolic Aspects and of Hyperhomocysteinemia comprehensively covers the nutritional-based intervention for combating hyperhomocysteinemia-mediated oxidative stress, metabolic regulation of homocysteine-dependent transulfuration and transmethylation pathways, and the identification of novel biomarkers for early diagnosis of hyperhomocysteinemia. The main goal of this text is to address the biochemical and nutritional aspects of hyperhomocysteinemia in relation to increasing risk of chronic diseases, providing insight into the etiology of hyperhomocysteinemia and covering new research on the effective reduction and management of hyperhomocysteinemia-associated chronic diseases. For researchers seeking a singular source for the understanding of the biochemical aspects and nutrition-based combat of hyperhomocysteinemia, its risk factors, preventive measures, and possible treatments currently available, this text provides all of the important needed information in up-to-date and comprehensive form.
Author: Kilmer S. McCully
Publisher: McGraw Hill Professional
ISBN: 9780879839758
Category : Health & Fitness
Languages : en
Pages : 268
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Book Description
More than 30 years ago, a young Harvard pathologist offered the medical community a theory for the cause of one of today's biggest killers-- heart disease. It is called the Homocysteine Theory and is the medical breakthrough that inspired Andrew Weil to label Dr. McCully as a visionary medical pioneer well ahead of his time. This discovery has the potential to save millions, yet ironically destroyed Dr. McCully's medical career. Homocysteine, a byproduct of metabolism, has been discovered to be a better risk indicator of heart disease than high cholesterol. A simple B6 vitamin and folic acid play a major role in controlling homocysteine levels. This proven theory will change the way the medical establishment views and treats heart disease. Today, the medical community is beginning to accept Dr. McCully's findings transforming his story from medical heresy to legitimate medicine. Updated and revised, complete with a new introduction by Walter Wilett, this eye opening book combines Dr. McCully's personal story and scientific philosophy with a fascinating exposition of his discovery and a special program to make use of this information to improve overall health.
Author: Ralph Carmel
Publisher: Cambridge University Press
ISBN: 9780521653190
Category : Medical
Languages : en
Pages : 558
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Book Description
This is an unusually comprehensive 2001 account of the broad range of medical implications of homocysteine.
Author: Saurabh Mehta
Publisher: CRC Press
ISBN: 1351058185
Category : Medical
Languages : en
Pages : 326
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Book Description
The world continues to lose more than a million lives each year to the HIV epidemic, and nearly two million individuals were infected with HIV in 2017 alone. The new Sustainable Development Goals, adopted by countries of the United Nations in September 2015, include a commitment to end the AIDS epidemic by 2030. Considerable emphasis on prevention of new infections and treatment of those living with HIV will be needed to make this goal achievable. With nearly 37 million people now living with HIV, it is a communicable disease that behaves like a noncommunicable disease. Nutritional management is integral to comprehensive HIV care and treatment. Improved nutritional status and weight gain can increase recovery and strength of individuals living with HIV/AIDS, improve dietary diversity and caloric intake, and improve quality of life. This book highlights evidence-based research linking nutrition and HIV and identifies research gaps to inform the development of guidelines and policies for the United Nations’ Sustainable Development Goals. A comprehensive approach that includes nutritional interventions is likely to maximize the benefit of antiretroviral therapy in preventing HIV disease progression and other adverse outcomes in HIV-infected men and women. Modification of nutritional status has been shown to enhance the quality of life of those suffering HIV/AIDS, both physically in terms of improved body mass index and immunological markers, and psychologically, by improving symptoms of depression. While the primary focus for those infected should remain on antiretroviral treatment and increasing its availability and coverage, improvement of nutritional status plays a complementary role in the management of HIV infection.
Author: Prodromos A. Prodromou
Publisher:
ISBN:
Category : Cardiovascular system
Languages : en
Pages : 266
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Book Description
Author: Maria Victoria Medina
Publisher:
ISBN: 9781124907765
Category :
Languages : en
Pages :
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Book Description
Homocysteine is a risk factor for vascular disease, though the mechanism by which homocysteine contributes to vascular disease has not been definitively established. Recent studies suggest that elevated blood levels of homocysteine cause endothelial injury. High levels of homocysteine have been shown to upregulate VCAM-1 expression and adhesion of monocytes to the endothelium in cultured endothelial cells, animals, and humans. Elevated expression of vascular adhesion molecules are often observed in sickle cell disease (SCD) and diabetes patients and may contribute to the vascular morbidity observed in these conditions. Elevated homocysteine is also observed in SCD and diabetes patients, and thus may contribute to vascular disease in these patients through mechanisms involving vascular adhesion molecules. The dissertation research presented in this thesis sought to elucidate mechanisms of homocysteine in vascular disease by exploring the associations between homocysteine, B vitamins, and adhesion molecules in patients with SCD and diabetes via three studies. The first study assessed associations between vitamin B6, homocysteine, and inflammatory markers in adult SCD patients. SCD patients had lower plasma pyridoxal-5'-phosphate (PLP) and higher plasma homocysteine, CRP and sVCAM-1 compared with age, sex, and ethnicity matched controls. No significant correlations were observed between homocysteine and these inflammatory markers. However, a significant inverse correlation was found between PLP and sVCAM-1 in the patients, which suggests that low B6 status may contribute to vascular complications in SCD patients through a VCAM-1-mediated mechanism. The second study assessed whether there was an association between homocysteine and markers of inflammation and endothelial dysfunction in diabetic patients. In a cross-sectional study, we found that mean plasma homocysteine, soluble sVCAM-1 and soluble intercellular adhesion molecule-1 (sICAM-1) concentrations in Type 1 and Type 2 diabetic patients were significantly higher than in healthy controls. Although homocysteine did not correlate with either sICAM-1 or C-reactive protein (CRP), sVCAM-1 was directly correlated with homocysteine in all three groups. The last study sought to evaluate whether a multi B vitamin supplement could reduce homocysteine and inflammatory markers. B vitamin supplementation (folic acid, vitamin B12, vitamin B6, vitamin B2, and choline) was administered in a placebo-controlled, double-blind, randomized study to patients with Type 2 diabetes for three months. Although homocysteine concentrations modestly decreased in response to supplementation, there was no significant effect on sVCAM-1, sICAM-1, or CRP. Most of the subjects had homocysteine levels that were in the normal range prior to treatment. However, two patients had markedly elevated homocysteine concentrations and these two subjects had the highest baseline sVCAM-1 levels of the entire cohort. One subject responded to supplementation with a 50% decrease in homocysteine levels and a 16% reduction in sVCAM-1 concentration while the other patient, who was given the placebo, showed increases in both homocysteine (10%) and sVCAM-1 (17%) concentration. These findings indicate that lowering homocysteine levels when in the normal range does not affect markers of endothelial dysfunction or inflammation in patients with Type 2 diabetes. However, the findings do not rule out the possibility that supplementation with B vitamins may be effective for patients with diabetes who have markedly elevated homocysteine levels. Future studies that assess the efficacy of B vitamin supplementation in reducing markers of inflammation and thereby vascular disease in adult patients with SCD and diabetic patients who have elevated concentrations of homocysteine may be clinically beneficial.
