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Author: S. J. Baum
Publisher: Springer Science & Business Media
ISBN: 1461298954
Category : Medical
Languages : en
Pages : 247
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Book Description
It is perhaps not too much of an exaggeration to claim that experimental hematology as it flourishes today originated largely from the pioneering attempts to protect lethally radiated animals (1) by shielding of hemopoietic tissues by L.O. Jacobson (9), and (2) by treatment with bone marrow suspensions by E. Lorenz and his col laborators (12). The site chosen for this annual meeting of the International Society for Experi mental Hematology is given a special historic sig nificance by the fact that it was 25 years ago that the first publication on this subject by Lorenz ap peared from his laboratory at the National Insti tutes of Health. Lorenz's discovery marked the beginning of a period which lasted until 1956, during which the protection afforded by hemopoietic cell suspensions was confirmed by many. This soon led to an intensive scientific de bate on the mechanism of this protective effect: was it due to a humoral factor produced and pro vided by the bone marrow-as Lorenz The Appearance of postulated-or to transplantation and subsequent proliferation of hemop- etic cells? This question was defini- 1 the Multipotential tively answered in 1956 by evidence from three different laboratories (7, 15, 26), which demonstrated the origin of the cells Hemopoietic in the repopulated tissues using a variety of cellu lar and immunologic markers. By the same token, these contributions marked the birth of radiation Stem Cell chimeras.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1442
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Book Description
First multi-year cumulation covers six years: 1965-70.
Author: Clifford Smith
Publisher: John Wiley & Sons
ISBN: 1405171073
Category : Medical
Languages : en
Pages : 164
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Book Description
A vital resource on blood and bone marrow cell morphology in laboratory animal medicine. This fully revised new edition is an essential reference for clinical pathologists in diagnostic laboratories, and medical or veterinary research. The atlas contains over 400 color images of cells from the peripheral blood and bone marrow from a variety of animals encountered in laboratory animal medicine, in health and disease. Key features: New chapter on flow cytometry and its application in terms of routine analyses as a means of identifying abnormalities in cell marker expression, which is of particular relevance for pre-clinical safety assessment Covers the most recent developments in laboratory animal hematology, including parameters measured by the latest generation of analyzers Coverage of a wide range of laboratory animal species, as well as those used in clinical veterinary trials Photomicrographs present normal and abnormal blood cells from a variety of hematological conditions along with descriptive text
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1516
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Book Description
A keyword listing of serial titles currently received by the National Library of Medicine.
Author: Mehdi Tavassoli
Publisher: Springer Science & Business Media
ISBN: 1461244943
Category : Medical
Languages : en
Pages : 469
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Book Description
In 1868, Ernst Neumann recognized that blood cells re quire continuous replenishment during postnata1life. Before him, the assumption was that cells of the blood, like nerves once formed in the embryo, remain in the body throughout life. Neumann also recognized that this process occurred within the bone marrow, because this tissue provided a fa vorable environment for proliferation and differentiation of blood cell precursors. Vera Danchakoff, the Russian embryologist working in the US, in 1916 made an analogy to the soil and the seed. Bone marrow forms the soil, providing a favorable environment for the growth of seed, the hemopoietic stem cell, and other progenitor cells. Imagine in the remote past a heap of similar tree seeds. These seeds develop in our moderate climate into a tall and many branched tree. Suppose the wind bears a part of the seeds away and brings them to a land possessing different environmental conditions, we will say the arc tic lands. There the seeds may develop but they may pro duce trees no higher than our moss.
Author: S. Thierfelder
Publisher: Springer Science & Business Media
ISBN: 3642673198
Category : Medical
Languages : en
Pages : 418
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Book Description
Bone marrow transplantation, the goal which integrates hemato logists, immunologists, geneticists, oncologists and specialists of several other fields, has overcome its state of stagnation in recent years. Clinically as well as experimentally new approaches to old problems and new conclusions from recent findings proliferate: bone marrow transplantation in leukemic remission, bone marrow growth in cell culture, bone marrow manipulation with antisera, bone marrow differentiation in histoincompatible hosts, immuno suppression with partial body irradiation to cite just a few. These and other new developments were discussed by experts from 12 countries in and outside the European Community during an international seminar held on March 8-10, 1979 by the "Institut fur Hamatologie, GSF", under the auspices of the European Communities. The editors thank both the contributors to this symposium, who made it a successful meeting and submitted their manuscripts punctually, and the publishers, who have provided a volume of high quality in good time. They are also grateful for the valuable cooperation from numerous colleagues at the Institut fur Hamato logie.
Author: A. Hagenbeek
Publisher: Springer Science & Business Media
ISBN: 9400942737
Category : Medical
Languages : en
Pages : 407
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Book Description
Relapse of leukemia following successful remission-induction therapy remains a major obstacle in the treatment of patients with acute leukemia. Leukemia recurs most frequently in patients with acute myeloblastic leukemia (AML) and high risk acute lymphoblastic leukemia (ALL) following chemotherapy and less often in patients with low risk ALL and particularly in patient groups> submitted to allogeneic marrow transplantation. ' It is likely that the great majority of these recurrences originate from residual leukemic cells that survive initial remission-induction chemotherapy. Today, several research groups throughout the world place emphasis on studies concerned with the detection and treatment of 'minimal residual disease' (MRD). These investigations are conducted with the common objective to tackle the remaining cells. 'Minimal Residual Disease in Acute Leukemia: 1986' summarizes the fast advancements in this area. Several disciplines are concerned with the analysis of leukemic cells. The perspectives of cytogenetic and molecular genetic approaches for applica tion in the detection of MRD are reviewed. In this respect, modern cyto genetics provide highly specific tumor markers. The resolution of cyto genetic methods can be particularly improved when combined with other techniques which select relevant subpopulations of cells. Characterization of oncogenes and gene rearrangements, including those of immunoglobulin and T-cell receptor genes, and the measurement of gene products, have been established. Techniques based on these approaches offer interesting tools for the detection of MRD. New possibilities of employing monoclonal anti bodies are also presented.
Author: J.J. Broerse
Publisher: Springer Science & Business Media
ISBN: 9400960484
Category : Medical
Languages : en
Pages : 233
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Book Description
J.J. Broerse, Radiobiological Institute TNO, Rijswijk, The Netherlands, and T .J. MacVittie, Armed Forces Radiobiology Research Institute, Bethesda, MD, USA. During the past decade, relatively few new studies have been initiated on the response of different species to high-dose, total-body irradia tion. For information on the LDSO/30d (the dose which produces 50 percent lethality within 30 days), one is generally referred to the older literature (e. g., Bond, Fliedner and Archambeau, 1965). Compari son of experimental data reveals considerable variations in LDSD values even after total-body irradiation with conventional X rays, ranging from 4 to 6 Gy in the monkey, 7.1 to 9 Gy in the rat and from 6.4 to 9 Gy in the mouse (see also Hall, 1978). Part of the discrepancy in the LDso values can possibly be attributed to inadequacies in the dosimetry procedures and exposure arrangements employed. As far as clinical experience is concerned, there is now an appreciable amount of information available about the effect of total body irradiation as a conditioning treatment for bone marrow transplan tation in patients suffering from leukaemia or aplastic anaemia. The results from different centres, including the incidence of complications such as radiation pneumonitis, are considerably different. This can part I y be connected with the application of different radiation sched ules: large single dose versus fractionated or protracted irradiation.
Author: Alton L. Boynton
Publisher: Academic Press
ISBN: 148327666X
Category : Science
Languages : en
Pages : 529
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Book Description
Control of Animal Cell Proliferation, Volume II discusses how animal cells become proliferatively autonomous, which results in malignant behavior. This book begins with trends and issues on membrane structure and teratocarcinoma research. The structure and function of several growth factors and their receptors such as thrombin, transferrin, glucocorticoid, and B and T cell factors are also discussed. This text likewise covers the mechanism of information transduction that includes intracellular pH and calcium. The aspects of genome organization and gene transcription are deliberated in the last chapters. This publication provides biologists and students with a coherent picture of cell proliferation.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 952
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Book Description
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 988
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Book Description
