Ethyl-nitrosourea Induced Mutagenesis in Escherichia Coli PDF Download
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Author: Zhehong Cai
Publisher:
ISBN:
Category :
Languages : en
Pages : 218
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Book Description
Author: Zhehong Cai
Publisher:
ISBN:
Category :
Languages : en
Pages : 218
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Book Description
Author: Kristin A. Eckert
Publisher:
ISBN:
Category :
Languages : en
Pages : 418
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Author: Martinus R. Schaaper
Publisher:
ISBN:
Category :
Languages : en
Pages : 106
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Author: Christian P. Coogan
Publisher:
ISBN:
Category :
Languages : en
Pages : 180
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Book Description
N -ethyl- N -nitrosourea (ENU) is an alkylating agent that forms covalent adducts in DNA. These adducts promote the occurrence of mutations. In a previous study, the frequency of ENU-induced mutations in a strain of Escherichia coli (FX-11) having a palindromic target sequence was asymmetric. This result suggested a possible difference between leading and lagging strand replication complexes in the formation of ENU-induced mutations. In this research, gene inversion was studied by constructing two derivatives of E. coli FX-11 that contained the target allele ( tyr A14) in opposite orientations with respect to the replication fork. ENU-induced mutagenesis produced different base changes in the nonsense defect that restored tyr A14 function (backmutants). Mutation frequency analysis revealed that replication orientation did have an affect on ENU-induced mutagenesis. However, this affect only occurred when the damage was located on the transcribed strand, in which case leading strand synthesis was more mutagenic than lagging strand synthesis.
Author:
Publisher: Springer Science & Business Media
ISBN: 3642747752
Category : Medical
Languages : en
Pages : 617
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Book Description
I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.
Author: Colin S. Cooper
Publisher: Springer Science & Business Media
ISBN: 3642747787
Category : Medical
Languages : en
Pages : 482
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Book Description
I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABETH CA VERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.
Author:
Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages : 366
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Author:
Publisher:
ISBN:
Category : Carcinogenicity testing
Languages : en
Pages : 372
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Author: Manfred Schwab
Publisher: Springer Science & Business Media
ISBN: 3642468705
Category : Medical
Languages : en
Pages : 372
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Book Description
Different cancer types can result from a multiplicity of genetic and environmental factors. In recent years a number of genes have been identified as strong determinants for particular forms of cancer (particularly colon and breast cancer). The incomplete penetrance often evinced by the mutations of these genes has raised the possibility that additional endogenous or exogenous determinants contribute to cancer development or suppression. The major aim of this book is to present an integrated view of the various environmental, epidemiological and genetic determinants that contribute to a disease syndrome collectively known as "cancer".
Author: Jon A. Wolff
Publisher: Springer Science & Business Media
ISBN: 1468468227
Category : Medical
Languages : en
Pages : 431
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Book Description
During the first half century of genetics, coinciding with the first half of this cen tury, geneticists dreamt of the repair of genetic disease by altering or replacing defective genes. H. J. Muller wrote of the great advantages of mutations, "nanoneedles" in his apt term, for delicately probing physiological and chemical processes. In the same spirit, genes could be used to provide treatments of needle point delicacy. Yet, during this period no realistic possibility appeared; it remained but a dream. The situation changed abruptly at the half century. Microbial genetics and its offshoot, cell culture genetics, provided the route. Pneumococcus transformation showed that exogenous DNA could become a permanent part of the genome; yet attempts to reproduce this in animals produced a few tantalizing hints of success, but mostly failures. Transduction, using a virus as mediator, offered a better op portunity. The fITSt reproducible in vivo gene therapy in a whole animal came in 1981. This was in Drosophila, with a transposable element as carrier. Flies were "cured" of a mutant eye color by incorporation of the normal allele, and the effect was transmissible, foreshadowing not only somatic, but germ line gene therapy. At the same time, retroviruses carrying human genes were found to be ex tremely efficient in transferring their contents to the chromosomes of cultured cells.
