Epithelial Stromal Interaction in Breast Cancer PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Epithelial Stromal Interaction in Breast Cancer PDF full book. Access full book title Epithelial Stromal Interaction in Breast Cancer by Eldo Thomas Verghese. Download full books in PDF and EPUB format.
Author: Eldo Thomas Verghese
Publisher:
ISBN:
Category :
Languages : en
Pages : 422
Get Book Here
Book Description
Author: Eldo Thomas Verghese
Publisher:
ISBN:
Category :
Languages : en
Pages : 422
Get Book Here
Book Description
Author: Tianshu Li
Publisher:
ISBN:
Category :
Languages : en
Pages : 130
Get Book Here
Book Description
Breast cancer is the major cause of cancer death among women worldwide. Understanding the mechanisms underlying breast cancer progression remains urgent for developing effective treatment strategies to eliminate breast cancer mortality. Our recent studies have demonstrated that Krüppel-like transcriptional factor 8 (KLF8) plays a critical role for breast cancer progression. Other studies have shown that Epithelial stromal interaction 1 (EPSTI1), a recently identified stromal fibroblast-induced gene in non-invasive breast cancer cells and epidermal growth factor receptor (EGFR) are highly overexpressed in aggressively invasive breast carcinomas including triple negative breast cancers. In this thesis project, we demonstrate high co-overexpression of KLF8 with EPSTI1 as well as EGFR in invasive breast cancer cells and patient tumors. We also show that KLF8 upregulates the expression of EPSTI1 by directly binding and activating the EPSTI1 gene promoter, and KLF8 upregulates the expression of EGFR not only by directly activating the EGFR gene promoter but also by preventing EGFR translation from microRNA141-dependent inhibition. Genetic, signaling and animal cancer model analyses indicate that downstream of KLF8, EPSTI1 promotes the tumor invasion and metastasis by activating NF-[kappa]B through binding valosin containing protein (VCP) and subsequent degradation of I[kappa]B[alpha], whereas EGFR promotes tumor growth and metastasis via activation of ERK. Taken together, these data identify EPSTI1 and EGFR as novel KLF8 targets in breast cancer and suggest that KLF8 may be targeted for new effective treatment of breast cancer.
Author: Alison Sarah Waterworth
Publisher:
ISBN:
Category :
Languages : en
Pages : 334
Get Book Here
Book Description
Author: Sanober Aftab Amin
Publisher:
ISBN:
Category :
Languages : en
Pages : 338
Get Book Here
Book Description
Author: Itzhak D. Goldberg
Publisher: Birkhäuser
ISBN: 3034890702
Category : Science
Languages : en
Pages : 304
Get Book Here
Book Description
The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.
Author: C. Palmieri
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 27
Get Book Here
Book Description
The work done to date has helped to better characterize the breast cancer microenvironment. We have confirmed that the expression normal adjacent tissue is not distinct from healthy breast reduction tissue. The genes specific to normal epithelium also identify basal-like breast tumors, potentially explaining their resistance to treatment. The interactions involving the tumor immune cells have the strongest detectable signals using the methods developed by this project. We are the first group to characterize the expression of the blood vessels in breast cancer. We have confirmed the presence of low-density mature vessels and high-density immature vessels. Surprisingly, the expression from those mature tumor vessels more closely match the characteristics of tumor vessels in other cancers. This will open new roads for a better understanding of neo-vascularization in breast cancer as well as helping to target treatment more effectively. Our work in mouse models has also identified osteoactivin as a potential effector of bone metastasis.
Author: Stephanie Chantal Lebret
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 472
Get Book Here
Book Description
This study determined that the microenvironment influences mammary cellular development and that this microenvironment differs between normal and malignant tissue. Cancer-associated fibroblasts, loss of an extracellular protein and presence of a growth factor were demonstrated to influence cancer cell migration, presenting a basis for the understanding of breast cancer metastasis.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Successful tumor growth requires angiogenesis, or the sprouting of new blood vessels from existing ones, to supply tumor cells with essential nutrients and oxygen. In addition, cancer cells must also establish a productive interaction with their neighboring stroma, which produces a matrix environment conducive to tumor growth and may also help shield tumor cells against systemic immune surveillance. A novel angiogenic factor essential for vascular development, Cyr61, has been recently identified as a marker for invasive breast carcinomas. We have found that the receptor for Cyr61 in breast cancer cells is integrin alpha 6 beta 1. Cyr61 also inhibits the proliferation of normal breast epithelial cells and MCF7 carcinoma cells, in part through enhancing apoptotic pathways. A new hypothesis on the role of Cyr61 in breast cancer cell growth is currently being tested.
Author: Mani T. Valarmathi
Publisher: BoD – Books on Demand
ISBN: 1789849845
Category : Science
Languages : en
Pages : 262
Get Book Here
Book Description
Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.
