Environmental Effects of Dredging. Evaluation of Sediment Genotoxicity. Workshop Summary and Conclusions PDF Download
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Languages : en
Pages : 10
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Book Description
This Technical Note summarizes the proceedings of a workshop that was held March 6-8,1990, at the Environmental Laboratory, US Army Engineer Waterways Experiment Station. The purpose of the workshop was to gain guidance from recognized authorities for the development of sediment bioassays of genotoxicity, that is, mutagenicity, carcinogenicity, immunotoxicity, teratogenicity, and histopathologic potential. The conclusions of the workshop are being used to identify existing genotoxicity bioassays that show promise for application in evaluating sediments, to recommend modifications for testing sediments, and to help direct subsequent research and development of bioassays of genotoxicity by the US Army Corps of Engineers.
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Publisher:
ISBN:
Category :
Languages : en
Pages : 10
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Book Description
This Technical Note summarizes the proceedings of a workshop that was held March 6-8,1990, at the Environmental Laboratory, US Army Engineer Waterways Experiment Station. The purpose of the workshop was to gain guidance from recognized authorities for the development of sediment bioassays of genotoxicity, that is, mutagenicity, carcinogenicity, immunotoxicity, teratogenicity, and histopathologic potential. The conclusions of the workshop are being used to identify existing genotoxicity bioassays that show promise for application in evaluating sediments, to recommend modifications for testing sediments, and to help direct subsequent research and development of bioassays of genotoxicity by the US Army Corps of Engineers.
Author: Francis J. Reilly
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: G.Allen Burton
Publisher: CRC Press
ISBN: 1351093452
Category : Science
Languages : en
Pages : 362
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Book Description
Sediment Toxicity Assessment provides the latest information regarding how to evaluate sediment contamination and its effects on aquatic ecosystems. It presents an integrated ecosystem approach by detailing effective assessment methods, considerations, and effects to each major component of marine and freshwater systems, including the benthos, plankton, and fish communities. The approaches emphasize defining habitat conditions (physical and chemical), toxicant bioavailability, factors influencing toxicity (lab and field), biomarkers, acute and chronic toxicity, study design, collection methods, and EPA management strategies. The book also explains how to integrate the assessments. Sediment Toxicity Assessment will be useful to to all environmental managers, environmental scientists, ecotoxicologists, environmental regulators, aquatic ecologists, environmental contractors and consultants, instructors, students, conservation commissions, and environmental activist organizations.
Author:
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Category :
Languages : en
Pages : 11
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Book Description
This technical note reports and compares initial results of six genotoxicity bioassays applied to dredged sediments and describes progress toward development of a testing protocol to aid in regulatory decisionmaking when genotoxic chemicals are an issue of concern. The Long-term Effects of Dredging Operations Program work unit Genotoxicity of contaminated Dredged Material was initiated in fiscal year 1990 to develop methods for assessing the genotoxic potential of dredged sediments. The impetus driving this new research and development effort was specific regulatory language in section 103 of the Ocean Dumping Act (Marine Protection, Research, and Sanctuaries Act (MPRsA) of 1972) prohibiting the open-water discharge of mutagenic, carcinogenic, or teratogenic substances in other than trace amounts, and language less specific but of similar intent in section 404 of the Clean Water Act (CWA). pg1. JMD.
Author: U.S. Army Engineer Waterways Experiment Station
Publisher:
ISBN:
Category : Coastal engineering
Languages : en
Pages : 408
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Author:
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Category :
Languages : en
Pages : 6
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This technical note describes an approach for assessing the genotoxic potential of dredged material. The use of integrated batteries of rapid and mechanistically interpretable in vitro and in vivo assays in a tiered approach is fundamental to applied toxicology. The research described here brings this approach to the testing of sediments. Work completed to date and future work will mesh to form an advanced and cost-effective methodology. The purpose of this methodology is to increase the accuracy of environmental risk assessments and facilitate making decisions concerning open-water disposal of dredged material. A great number of the contaminants typically found in dredged material are toxic to exposed organisms through effects on DNA. Such effects are usually the result of low-level chronic exposures. These effects can result in reproductive failure of organisms, impaired growth and development of offspring, and tumors (often cancerous) in vertebrates. Collectively, such effects are called 'genotoxicity' and result from damage to the genome of a cell. The damage is heritable, that is, passed on to future cell generations upon duplication of the affected cells.
Author:
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ISBN:
Category : Science
Languages : en
Pages : 928
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Author:
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ISBN:
Category :
Languages : en
Pages : 14
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This note summarizes the proceedings of a workshop held April 3-5,1990, at the US Army Engineer Waterways Experiment Station, Vicksburg, MS. The purpose of the workshop was to solicit input from technical experts regarding techniques for evaluating the chronic sublethal effects of sediments on aquatic biota. This input will be used to help direct subsequent research and development by the US Army Corps of Engineers.-BKA.
Author:
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Category :
Languages : en
Pages :
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 8
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Book Description
This technical note is the second in a series of three that outline and describe the principal methods that have been developed to test the potential of environmental contaminants for causing mutagenic, carcinogenic, and teratogenic effects. The first in this series (EEDP-04-24) describes methods used to discern genotoxic effects at the subcellular level, while this technical note describes methods used to discern genotoxic effects at the cellular and organ/ organism level. Recent literature citations for each topic are listed in the third technical note (EEDP-04-26) to assist readers in locating source information. A glossary of terms is also provided in Technical Note EEDP-O4-26. The information in these technical notes is intended to provide Corps of Engineers personnel with a working knowledge of the terminology and conceptual basis of genotoxicity testing. To develop an improved understanding of the concepts of genotoxicity, readers are encouraged to review "A Primer in Genotoxicity" (Farvis, Reilly, and Lutz 1993), presented in Volume D-933 of the Environmental Effects of Dredgtng information exchange bulletin.
