Environmental and Lifestyle Influences on Breast Cancer Risk PDF Download
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Author: Mary-Claire King
Publisher:
ISBN:
Category :
Languages : en
Pages : 22
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Book Description
Women with inherited mutations in BRCAl or BRCA2 have significantly elevated risks of breast cancer. However, not all women with inherited BRCAl or BRCA2 mutations develop breast or ovarian cancer, and among those who do, ages at cancer onset vary widely even within the same family. If a woman with a BRCAl or BRCA2 mutation remains free of breast cancer for many years, it is possible that her status is due to chance, to modifying genes segregating in some families, or to environmental factors that influence risk. In this project, we evaluate environmental and lifestyle factors that could influence the impact of mutations in BRCA I and BRCA2 on disease risk. It is possible that such co-factors identified among genetically predisposed women may be generalized to women who have not inherited predisposition to breast or ovarian cancer, because clinically and biologically, inherited cancer is virtually indistinguishable from its far more common, non-inherited counterpart.
Author: Mary-Claire King
Publisher:
ISBN:
Category :
Languages : en
Pages : 22
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Book Description
Women with inherited mutations in BRCAl or BRCA2 have significantly elevated risks of breast cancer. However, not all women with inherited BRCAl or BRCA2 mutations develop breast or ovarian cancer, and among those who do, ages at cancer onset vary widely even within the same family. If a woman with a BRCAl or BRCA2 mutation remains free of breast cancer for many years, it is possible that her status is due to chance, to modifying genes segregating in some families, or to environmental factors that influence risk. In this project, we evaluate environmental and lifestyle factors that could influence the impact of mutations in BRCA I and BRCA2 on disease risk. It is possible that such co-factors identified among genetically predisposed women may be generalized to women who have not inherited predisposition to breast or ovarian cancer, because clinically and biologically, inherited cancer is virtually indistinguishable from its far more common, non-inherited counterpart.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 19
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Book Description
This project aims to identify potentially preventable environmental influences on breast and ovarian cancer by focusing on a population of women with genetically inherited predisposition to the disease. This is an extension of our ongoing research into the genetics of breast and ovarian cancer among Jewish women in the New York City area. The IDEA project centered on female relatives of breast cancer patients with confirmed mutations in BRCAl or BRCA2. Each relative provided a blood sample for mutation testing and completed an extensive questionnaire addressing epidemiologic factors in breast cancer risk. Among participants, inherited mutations in BRCAl and BRCA2 were more frequent in women with a younger breast cancer diagnosis and in women with a breast and/or ovarian cancer family history. Breast cancer risks increased over time among women with mutations, suggesting the influence of environmental factors. The experiences and exposures of women with mutations who did and did not develop breast or ovarian cancer were compared to identify factors that ameliorate or exacerbate risk in this high-risk group. These risk factors may be generalized to women without inherited vulnerability to breast or ovarian cancer, as inherited cancer is virtually indistinguishable, clinically and biologically, from its non inherited counterpart.
Author: American Institute for Cancer Research
Publisher: Springer Science & Business Media
ISBN: 1461525101
Category : Medical
Languages : en
Pages : 190
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Book Description
The fourth annual American Institute for Cancer Research (AICR) conference on diet, nutrition and cancer was held at the L'Enfant Plaza Hotel in Washington, D. C. , September 2~3, 1993. In keeping with present concerns and in line with current trends, the theme was "Diet and Breast Cancer. " This proceedings volume is comprised of chapters from the platform presentations of the two day conference and abstracts from the poster session held at the end of the first day. Experimentally, there is sufficient evidence to support a relationship between dietary fat and the risk of breast cancer. A meta-analysis was provided by data from 114 experiments with over 10,000 animals, divided into groups fed ad libitum on diets with different levels or sources of fat, or different levels of energy restriction. This exercise suggested that linoleic acid was a major determinant of mammary tumor development but that other fatty acids also enhanced mammary tumor development in animals. However, as mentioned by several speakers, results from epidemiological studies often are conflicting, thus leading to confusion among both health professionals and the public. Surveys of specific populations which have migrated from countries with low breast cancer rates to those with higher rates are often some of the most compelling studies with respect to a high fat diet-breast cancer association. Nonetheless, various cohort and prospective studies, some quite large, did not appear to show a relationship between consumption of fat (any type) and breast cancer.
Author: Canadian Breast Cancer Initiative. Working Group on Primary Prevention of Breast Cancer
Publisher:
ISBN: 9780662308171
Category : Breast
Languages : en
Pages :
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Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309220696
Category : Medical
Languages : en
Pages : 468
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Book Description
Breast cancer remains the most common invasive cancer among women. The primary patients of breast cancer are adult women who are approaching or have reached menopause; 90 percent of new cases in U.S. women in 2009 were diagnosed at age 45 or older. Growing knowledge of the complexity of breast cancer stimulated a transition in breast cancer research toward elucidating how external factors may influence the etiology of breast cancer. Breast Cancer and the Environment reviews the current evidence on a selection of environmental risk factors for breast cancer, considers gene-environment interactions in breast cancer, and explores evidence-based actions that might reduce the risk of breast cancer. The book also recommends further integrative research into the elements of the biology of breast development and carcinogenesis, including the influence of exposure to a variety of environmental factors during potential windows of susceptibility during the full life course, potential interventions to reduce risk, and better tools for assessing the carcinogenicity of environmental factors. For a limited set of risk factors, evidence suggests that action can be taken in ways that may reduce risk for breast cancer for many women: avoiding unnecessary medical radiation throughout life, avoiding the use of some forms of postmenopausal hormone therapy, avoiding smoking, limiting alcohol consumption, increasing physical activity, and minimizing weight gain. Breast Cancer and the Environment sets a direction and a focus for future research efforts. The book will be of special interest to medical researchers, patient advocacy groups, and public health professionals.
Author: Canadian Breast Cancer Reserch Initiative. Working Group on Primary Prevention of Breast Cancer
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Canada. Working Group on Primary Prevention of Breast Cancer
Publisher:
ISBN:
Category :
Languages : en
Pages : 82
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Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309169240
Category : Science
Languages : en
Pages : 160
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The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.
Author: Johng S. Rhim
Publisher: Springer Science & Business Media
ISBN: 1461402549
Category : Science
Languages : en
Pages : 239
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Book Description
Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including: · Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems · Oncogenes · Tumor suppressor genes · Viral transformation · In vitro model systems for viral, chemical and radiation carcinogenesis · Cell aging · The multistep nature of human carcinogenesis · The role of stem cells and the microenvironment in tumorigenesis · The genes involved in multistep carcinogenesis Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area! Features ؠ Multistep models ؠ Breast cancer/Stem cells ؠ Prostate cancer/Stem cells ؠ Multistep / Genes
Author: Canada. Population and Public Health Branch
Publisher:
ISBN: 9780662661924
Category :
Languages : en
Pages : 39
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