Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System PDF Download
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Author: Andrzej T. Slominski
Publisher: Springer Science & Business Media
ISBN: 3642196837
Category : Medical
Languages : en
Pages : 128
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Book Description
The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.
Author: Andrzej T. Slominski
Publisher: Springer Science & Business Media
ISBN: 3642196837
Category : Medical
Languages : en
Pages : 128
Get Book Here
Book Description
The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.
Author: Barbara A. Gilchrest
Publisher: Springer Science & Business Media
ISBN: 3540329536
Category : Medical
Languages : en
Pages : 205
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Book Description
The topic of skin aging is of growing importance to all working in the field of dermatology, aesthetic medicine and cosmetic medicine. Two internationally well-known and leading experts in the field present a comprehensive state-of-the-art review on all aspects of skin aging. With its clear, concise and reader-friendly format this book has all the potential to become the Bible of skin aging. Every specialist interested in dermatology, aesthetic medicine, cosmetic science, cutaneous biology and aging research will find indispensable information of great value for his or her daily work.
Author: Georg T. Wondrak
Publisher: Springer
ISBN: 9783319827506
Category : Medical
Languages : en
Pages : 0
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Book Description
It is now established that the interplay between environmental exposure and molecular stress response pathways plays a critical role in skin health and disease, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit patients in the near future. Coauthored by recognized international leaders in molecular and clinical biomedical sciences, this novel book provides a comprehensive perspective on environmental exposure-induced skin stress response pathways. Focusing on molecular opportunities targeting skin stress response pathways that are involved in cutaneous barrier function and repair, antimicrobial defense, immune regulation, inflammation, and malignant progression, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in skin health and disease with implications for small molecule therapeutic development.
Author: L. Kanerva
Publisher: Springer Science & Business Media
ISBN: 3662076772
Category : Medical
Languages : en
Pages : 1311
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Book Description
A highly practical approach to occupational dermatoses combined with the skill and experience of specialists in clinical and experimental dermatology. Great care is taken throughout to provide the information urgently needed for daily patient management, with concise tables, algorithms, and figures on how to optimise the diagnostic procedure for high-quality patient care and expert opinion. This handbook provides the relevant job descriptions, job-specific diagnostic algorithms and a detailed description of allergens and irritants such that readers can master even difficult and unusual problems in occupational dermatology.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9289021926
Category : Medical
Languages : en
Pages : 497
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Book Description
This book presents revised guideline values for the four most common air pollutants - particulate matter, ozone, nitrogen dioxide and sulfur dioxide - based on a recent review of the accumulated scientific evidence. The rationale for selection of each guideline value is supported by a synthesis of information emerging from research on the health effects of each pollutant. As a result, these guidelines now also apply globally. They can be read in conjunction with Air quality guidelines for Europe, 2nd edition, which is still the authority on guideline values for all other air pollutants. As well as revised guideline values, this book makes a brief yet comprehensive review of the issues affecting the application of the guidelines in risk assessment and policy development. Further, it summarizes information on: . pollution sources and levels in various parts of the world, . population exposure and characteristics affecting sensitivity to pollution, . methods for quantifying the health burden of air pollution, and . the use of guidelines in developing air quality standards and other policy tools. Finally, the special case of indoor air pollution is explored. Prepared by a large team of renowned international experts who considered conditions in various parts of the globe, these guidelines are applicable throughout the world. They provide reliable guidance for policy-makers everywhere when considering the various options for air quality management.
Author: T. Agner
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318055867
Category : Medical
Languages : en
Pages : 172
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Book Description
Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.
Author: Rebecca Gowland
Publisher: Cambridge University Press
ISBN: 1139619187
Category : Social Science
Languages : en
Pages : 237
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Book Description
Few things are as interesting to us as our own bodies and, by extension, our own identities. In recent years, there has been a growing interest in the relationship between the body, environment and society. Reflecting upon these developments, this book examines the role of the body in human identification, in the forging of identities, and the ways in which it embodies our social worlds. The approach is integrative, taking a uniquely biological perspective and reflecting on current discourse in the social sciences. With particular reference to bioarchaeology and forensic science, the authors focus on the construction and categorisation of the body within scientific and popular discourse, examining its many tissues, from the outermost to the innermost, from the skin to DNA. Synthesising two, traditionally disparate, strands of research, this is a valuable contribution to research on human identification and the embodiment of identity.
Author: Hywel Williams
Publisher: John Wiley & Sons
ISBN: 9781444300178
Category : Medical
Languages : en
Pages : 740
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Book Description
Evidence-based Dermatology, Second Edition is aunique book in the field of clinical dermatology. Written andedited by some of the world’s leading experts inevidence-based dermatology, it takes a highly evidence-basedapproach to the treatment of all major and many of the less commonskin conditions. The toolbox at the beginning of the book explaining how tocritically appraise different studies, along with the comprehensivereviewing and appraisal of evidence in the clinical chapters makesthis book distinctive in its field as do the treatmentrecommendations which are based on the discussion of the bestavailable evidence using a question-driven approach and a commonstructure on dealing with efficacy, drawbacks and implications forclinical practice.
Author: Katlein França
Publisher: Springer
ISBN: 3319463527
Category : Medical
Languages : en
Pages : 257
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Book Description
Dermatological conditions are intimately related to stress. Stress can affect, reveal or even exacerbate a number of skin disorders, including alopecia, seborrheic dermatitis, psoriasis, atopic dermatitis, pruritus, herpes, lichen planus, rosacea and urticarial. On the other hand, the skin disease itself could induce a secondary stress for the patient, influencing his or her quality of life. There is increasing evidence that stress influences disease processes and contributes to inflammation through the modulating hypothalamicpituitary- adrenal axis – releasing neuropeptides, neurotrophins, lymphokines and other chemical mediators from nerve endings to dermal cells. This is one of the first books published on this topic, focusing more on the basic science aspects of stress in dermatopathology (oxidants, antioxidants, and oxidative injury in dermatopathology, dermatopharmacology, and dermatotoxicology.) Most Psychodermatology texts adopt a practical approach to identify all types of Psychodermatology disorders, focusing on clinical treatment. This concise title offers a comprehensive and didactic approach to skin diseases caused or exacerbated by stress, as well as covers the immunology, role and effect of stress on skin disease, and quality of life in dermatology. In the current programs of medical residency in dermatology, little is taught about the relationship between stress and skin diseases and this book is an important tool for young dermatologists and psychodermatologists in training.
Author: Nathalie Boulanger
Publisher: Academic Press
ISBN: 0128114371
Category : Science
Languages : en
Pages : 500
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Book Description
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