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Author: Robert H. Kretsinger
Publisher: Springer
ISBN: 9781461415329
Category : Science
Languages : en
Pages : 0
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Book Description
In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.
Author: Robert H. Kretsinger
Publisher: Springer
ISBN: 9781461415329
Category : Science
Languages : en
Pages : 0
Get Book
Book Description
In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.
Author: Ivano Bertini
Publisher: CRC Press
ISBN: 9780824705206
Category : Medical
Languages : en
Pages : 1382
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Book Description
This Handbook on Metalloproteins focuses on the available structural information of proteins and their metal ion coordination spheres. It centers on the metal ions indispensable for life but also considers metal ions used as substitution probes in studies of metalloproteins. Emphasizing the structure-function relationship, the book covers the common and distinct characterstics of metallo- enzymes, proteins, and amino acids bonded to copper, zinc, iron, and more.
Author: Michael K. Johnson
Publisher: John Wiley & Sons
ISBN: 1119159857
Category : Science
Languages : en
Pages : 424
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Book Description
Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.
Author: Ivano Bertini
Publisher: CRC Press
ISBN: 148227082X
Category : Medical
Languages : en
Pages : 1108
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Book Description
This Handbook on Metalloproteins focuses on the available structural information of proteins and their metal ion coordination spheres. It centers on the metal ions indispensable for life but also considers metal ions used as substitution probes in studies of metalloproteins. Emphasizing the structure-function relationship, the book covers the commo
Author: Joseph J. Stephanos
Publisher: John Wiley & Sons
ISBN: 1118801520
Category : Science
Languages : en
Pages : 500
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Book Description
Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.
Author: Christon J. Hurst
Publisher: Springer Nature
ISBN: 3030971856
Category : Science
Languages : en
Pages : 671
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Book Description
This book explains the metabolic processes by which microbes obtain and control the intracellular availability of their required metal and metalloid ions. The book also describes how intracellular concentrations of unwanted metal and metalloid ions successfully are limited. Its authors additionally provide information about the ways that microbes derive metabolic energy by changing the charge states of metal and metalloid ions. Part one of this book provides an introduction to microbes, metals and metalloids. It also helps our readers to understand the chemical constraints for transition metal cation allocation. Part two explains the basic processes which microbes use for metal transport. That section also explains the uses, as well as the challenges, associated with metal-based antimicrobials. Part three gives our readers an understanding that because of microbial capabilities to process metals and metalloids, the microbes have become our best tools for accomplishing many jobs. Their applications in chemical technology include the design of microbial consortia for use in bioleaching processes that recover metal and metalloid ions from industrial wastes. Many biological engineering tasks, including the synthesis of metal nanoparticles and similar metalloid structures, also are ideally suited for the microbes. Part four describes unique attributes associated with the microbiology of these elements, progressing through the alphabet from antimony and arsenic to zinc.
Author: Jack Cazes
Publisher: CRC Press
ISBN: 9780824727871
Category : Science
Languages : en
Pages : 986
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Book Description
A convenient source of information for workers in analytical chemistry, experimental biology, physics, and engineering, the Encyclopedia of Chromatography, Second Edition stands as a quick reference source and clear guide to specific chromatographic techniques and principles. The book offers a basic introduction to the science and technology of the method, as well as additional references on the theory and methodology for analysis of specific chemicals and applications in a range of industries. It contains over 400 cross-referenced articles with more than 80 entirely new articles, including many new discussions on emerging technologies, instrumentation, and applications in chromatography.
Author: Valeria Culotta
Publisher: John Wiley & Sons
ISBN: 1118636864
Category : Science
Languages : en
Pages : 608
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Book Description
Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.
Author: Don Rittner
Publisher: Infobase Publishing
ISBN: 1438109997
Category : Biology
Languages : en
Pages : 417
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Book Description
Contains approximately 800 alphabetical entries, prose essays on important topics, line illustrations, and black-and-white photographs.
Author: Maria Luisa Grilli
Publisher: MDPI
ISBN: 3039437577
Category : Technology & Engineering
Languages : en
Pages : 170
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Book Description
The Special Issue contains ten research papers, three of which review papers. It is a miscellaneous composition encompassing several applications where metal oxides play a key role. Some papers also give insights into novel synthesis methods and processes aiming to reduce negative environmental impacts and increase materials and process efficiency, thus also covering a broader concern of sustainability issues. The topics covered in this issues are: transparent conductive oxides, ceramic composites for tool applications, oxides nanoparticles for A-TIG welding, critical raw materials saving, metallurgical waste treatment, oxides for high temperature applications, nanostructured oxides and composites for gas sensing and desulfuration, and metal oxides sorbents for CO2 capture.
