Emerging Translational Opportunities in Comparative Oncology with Companion Canine Cancers PDF Download
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Author: Mark W. Dewhirst
Publisher: Frontiers Media SA
ISBN: 2889636453
Category :
Languages : en
Pages : 201
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Book Description
Author: Mark W. Dewhirst
Publisher: Frontiers Media SA
ISBN: 2889636453
Category :
Languages : en
Pages : 201
Get Book Here
Book Description
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309379903
Category : Medical
Languages : en
Pages : 83
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Book Description
Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients. Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in animals as models for human disease - as one way to improve cancer drug development and reduce attrition of investigational agents. Tumors that spontaneously develop in pet dogs and other companion animals as a result of normal aging share many characteristics with human cancers, such as histological appearance, tumor genetics, biological behavior, molecular targets, and therapeutic response. In June 2015 the Institute of Medicine hosted a workshop to examine the rationale and potential for integrating clinical trials for pet patients with naturally occurring cancers into translational cancer research and development. Participants discussed the research needs, strategies, and resources to support greater integration of clinical trials for pets with cancer into translational research pathways, and challenges and potential solutions for facilitating that integration. This report summarizes the presentations and discussions from the workshop.
Author: Felisbina Luisa Queiroga
Publisher: Mdpi AG
ISBN: 9783039286171
Category : Science
Languages : en
Pages : 0
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Book Description
Cancer represents a major global challenge for medical practice in humans and companion animals. A plethora of basic and preclinical studies involving cell cultures and animal models have screened novel anti-cancer drugs and innovative treatments such as immunotherapy and gene-based therapy. In addition, emerging alternative translational models based on comparative oncology have shown promising results in anti-cancer drug discovery since companion animals develop spontaneous tumors and share the same environment as humans. Nonetheless, some gaps still exist in pre-clinical and clinical comparative animal models in terms of biological behavior, genetics, molecular pathways, as well as the immunological features of cancer that should be fulfilled to enhance their translational value. This Special Issue of Cancers contributes high-quality scientific evidence through novel data from preclinical and clinical studies performed in humans and/or animals. Thus, we hope that this set of articles will increase readers' knowledge within the scope of comparative and translational oncology and encourage further research into these innovative anti-cancer therapies.
Author: Rebecca A. Krimins
Publisher: CRC Press
ISBN: 0429508492
Category : Medical
Languages : en
Pages : 294
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Book Description
Learning from Disease in Pets: A ‘One Health’ Model for Discovery is the first encompassing reference guide for veterinarians, researchers and physicians on conducting studies using spontaneous models of disease in animals. The study of naturally occurring disease in (pet) animals can help model our understanding of the biology, prevention and therapy of human and animal diseases. Studies of pet dogs, for instance, can aid treatment of complex medical problems such as cancer, orthopedic, cardiopulmonary, and neuro-inflammatory diseases, and zoonotic infections. Each chapter within this novel cross-species approach is contributed by a leader, or leaders, in their field of research. Using clinical trials to learn how pets with real diseases respond to therapy can lead to breakthroughs in human medicine, as well as benefiting pets suffering from otherwise debilitating illness. Despite similarities of diseases across species, there are very few spontaneous models of disease used in research compared with models where disease is induced in healthy laboratory animals. Many medical researchers and veterinarians have a multitude of questions regarding how to use naturally occurring diseases in pets for the discovery of treatments and diagnostics: this book will demonstrate how to safely make this happen. This book encourages veterinarians to build on and disseminate existing findings for the wider benefit of pets and humans. Many pets suffering from incurable illnesses may benefit from clinical trials; the book includes a section on the imperative communication styles necessary within the research environment and with clients, a compelling discussion on the ethics of using pets in veterinary clinical research, comprehensive tables of diseases that spontaneously occur in animals and humans, the regulatory requirements necessary to move therapy from benchside research to patient bedside, as well as intricate details on how to design a robust clinical study.
Author: Katrin Sak
Publisher:
ISBN: 9781536198096
Category : Medical
Languages : en
Pages :
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Book Description
"Cancer is a serious and ever-growing health concern not only in humans but also in dogs. Considering the differences in average lifespans, people commonly experience the loss of their companion dogs, representing a traumatic event to pet owners. On the one hand, better nutrition and improved care with many recent advancements in veterinary medicine have allowed dogs to live longer. On the other hand, this has involved an increased prevalence of aging-related diseases, including different types of malignancies. In fact, cancer afflicts one in every three dogs, being the most common cause of canine death. Hence, dogs with cancer require treatment, but differently from the human oncology, there are only few established standards of care for clinical management of canine tumors, besides the lack of effective drugs. Research into identification of novel efficient anticancer compounds and development of new therapeutic options are therefore highly needed to help man's best friend in combating malignant neoplasms. Over the past few decades, researchers have paid attention to the health benefits of various plant secondary metabolites, leading to the development of several new drugs for human medicine. Proceeding from this success, in this book, the current knowledge about anticancer effects of plant-derived compounds in different canine cancer models is compiled, discussing the role of phytochemicals in vitro canine cancer cell lines, in vivo xenografted mice, and in tumor-bearing dogs. Although still limited, these data reveal a great potential of plant compounds in reducing proliferation and inducing death of cells derived from different types of canine tumors, allowing these natural substances to be considered as promising anticancer drug candidates for dogs. This approach can not only result in the development of more efficient therapeutic agents for canine oncology in the future, but also provide new possibilities for chemopreventive strategies. Finally, considering the high biological, histological, and clinical similarities between canine and human tumors, knowledge on bioactivities of specific phytochemicals in cancer-bearing dogs can ultimately benefit both species, accelerating drug development paths for humans and promoting general advancement of oncological discipline"--
Author: Lorenzo Manti
Publisher: Frontiers Media SA
ISBN: 2889740005
Category : Medical
Languages : en
Pages : 340
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Book Description
Author: Laura Bongiovanni
Publisher: Frontiers Media SA
ISBN: 2832514014
Category : Medical
Languages : en
Pages : 154
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Book Description
Author: Eugenie S. Kleinerman
Publisher: Springer Nature
ISBN: 3030430855
Category : Medical
Languages : en
Pages : 233
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Book Description
This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.
Author:
Publisher: BoD – Books on Demand
ISBN: 1839626542
Category : Science
Languages : en
Pages : 190
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Book Description
The advances being made in veterinary medicine in the modern era are continuously pushing the boundaries of what is presently possible and available. From unraveling canine genetics and gene therapies to understanding the microbiome and the effects parasites have on canine health. Whilst many advances are being made with clinical diagnosis, surgeries, prosthetics, pharmaceuticals, and imaging techniques, preventative medicine is also at the forefront of technology. Our understanding of the medical issues, critical care, pharmaceutics, anatomy, pathology, genetics, and disease are all imperative in making advances in canine medicine. This book covers a diverse range of topics in canine health by highlighting recent and forthcoming canine medicine and health innovations and improvements.
Author: Guido Bocci
Publisher: Springer
ISBN: 3662436043
Category : Medical
Languages : en
Pages : 302
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Book Description
This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
