Quadruplex Nucleic Acids As Targets For Medicinal Chemistry PDF Download
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Author:
Publisher: Academic Press
ISBN: 0128210184
Category : Science
Languages : en
Pages : 564
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Book Description
The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series
Author:
Publisher: Academic Press
ISBN: 0128210184
Category : Science
Languages : en
Pages : 564
Get Book Here
Book Description
The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series
Author: Mary H. Dickson
Publisher: Routledge
ISBN: 1134033974
Category : Technology & Engineering
Languages : en
Pages : 430
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Book Description
Geothermal energy refers to the heat contained within the Earth that generates geological phenomena on a planetary scale. Today, this term is often associated with man's efforts to tap into this vast energy source. Geothermal Energy: utilization and technology is a detailed reference text, describing the various methods and technologies used to exploit the earth's heat. Beginning with an overview of geothermal energy and the state of the art, leading international experts in the field cover the main applications of geothermal energy, including: electricity generation space and district heating space cooling greenhouse heating aquaculture industrial applications The final third of the book focuses upon environmental impact and economic, financial and legal considerations, providing a comprehensive review of these topics. Each chapter is written by a different author, but to a set style, beginning with aims and objectives and ending with references, self-assessment questions and answers. Case studies are included throughout. Whilst written primarily for professionals and students interested in learning more about geothermal energy, the book also offers those new to the field and the general geothermal community an opportunity to understand and review the potential of this exciting alternative energy source. Published with UNESCO
Author: Nasir El Bassam
Publisher: Newnes
ISBN: 0123971780
Category : Science
Languages : en
Pages : 418
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Book Description
It is estimated that more than two billion people worldwide lack access to modern energy resources. Renewable energy has the potential to bring power to these many communities and individuals who function off the grid. This book describes the latest advances in distributed and off-grid renewable energy technologies and offers strategies and guidelines for planning and implementation of sustainable, decentralized energy supply. Coverage includes wind, solar, geothermal, and biomass systems planning and integration, economic assessment models and the role of legislative structures. -- Back Cover.
Author: Dawn Ades
Publisher: Yale University Press
ISBN: 9780300045611
Category : Art
Languages : en
Pages : 400
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Book Description
This authoritative and beautiful book presents the first continuous narrative history of Latin American art from the years of the Independence movements in the 1820s up to the present day. Exploring both the indigenous roots and the colonial and post-colonial experiences of the various countries, the book investigates fascinating though little-known aspects of nineteenth and twentieth-century art and also provides a context for the contemporary art of the continent.
Author: Carol L. Schmid Professor of Sociology Guilford Technical Community College
Publisher: Oxford University Press, USA
ISBN: 0195350219
Category : Social Science
Languages : en
Pages : 230
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Book Description
Important aspects of the history of language in the United States remain shrouded in myth and legend. The notion of "one nation, one language" is part of the idealized history of the United States, although in its short history it has probably been host to more bilingual people than any other country in the world. Language is more than a means of communication. It brings into play an entire range of experiences and attitudes toward life. Furthermore, language is a potent symbolic issue because it links power and political claims of ownership with psychological demands for group worth. How people belonging to different language and cultural communities live together in the same political community and how political and structural tensions arise to divide them along language lines, are questions addressed in The Politics of Language. This book analyzes the historical background and recent controversy over language in the United States and compares it to two official multilingual societies: Canada and Switzerland. It's accessibility as a survey of this topic makes it ideal for courses in linguistics, political science, and sociology.
Author: Parviz M. Pour
Publisher: Springer Science & Business Media
ISBN: 4431683119
Category : Medical
Languages : en
Pages : 451
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Book Description
The classification of tumors is important for understanding tumor histogenesis, for predicting prognosis, for differential diagnosis, and for recommending appropriate therapy. Since 1836, when pancreatic cancer was first described, progress has been made in pancreatic cancer morphology, and a number of classifications have been proposed. All of these classifications are mainly based on morphological characteristics. Some are too detailed to be of practical use while others are more pragmatic. Some of the inherent problems in the previous classifications included difficulties in obtaining an adequate number of pan creatic tumors for examination and insufficient clinical data and follow-up. With the increasing incidence of pancreatic cancer in many parts of the world during the past six decades, and with the availability of more tumors to patho logists, advances have been made in pancreatic tumor studies. Classifications by Cubilla and Fitzgerald and by Kloppel, which are generally similar, mostly considered prominent morphological features and their histogenesis. These pathology-oriented classifications, although complete, were not practical from the standpoint of clinicians concerned with the prognosis of individual tumors.
Author: Agustín Barrios Mangoré
Publisher: Alfred Music
ISBN: 9781457494895
Category : Music
Languages : en
Pages : 16
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Book Description
A lovely haunting exercise in tremolo.
Author: Adrian Krainer
Publisher: IRL Press
ISBN:
Category : Language Arts & Disciplines
Languages : en
Pages : 408
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Book Description
This volume focuses on the major aspects of post-transcriptional mRNA processing in the nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper gene expression and can also serve as a control point for regulating the expression of many genes, for example duringembryonic development or in different cell types. The different chapters review the assembly of newly synthesized nuclear mRNA transcripts into hnRNP particles and catalytically active spliceosomes; the structure and mechanism of action of small nuclear ribonucleoprotein particles and proteinfactors that catalyse pre-mRNA splicing in mammalian cells and in yeast; the regulation of gene expression and generation of protein isoform diversity by alternative splicing; the mechanisms of 3' end cleavage and polyadenylation; the architecture of the cell nucleus in relation to these processesand to the localization of the relevant substrates and factors; the diverse mechanisms of RNA processing by ribozymes and their potential relevance for nuclear mRNA processing; the mechanism of spliced-leader addition by trans-splicing in nematodes and trypanosomes; and the process ofinsertion/deletion mRNA editing in kinetoplasmid protozoa. In each chapter, leading researchers have provided detailed, critical reviews of the history, experimental approaches, major advances, current ideas and models, as well as future directions, for each of these active areas of research.
Author: Joe D. Batten
Publisher: Wipf and Stock Publishers
ISBN: 1725201275
Category : Religion
Languages : en
Pages : 238
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Book Description
Sound advice that can be adapted by managers at all levels." 'B/M Book Review' The excellence of the book lies in the basic information it has to give the relatively new manager." 'Personnel Psychology' Must reading for anyone who thinks all management books are just a rehash of planing, organizing, staffing, controlling, etc.... Especially recommended...." 'NRHA Magazine' A totally fresh description of how to turn MBO into a 'living system'...practical and highly motivational. 'Buffalo Law Journal' Many useful suggestions to offer the executive." 'West Coast Review of Books'
Author: Agustín Barrios Mangoré
Publisher: Alfred Music
ISBN: 9781457494864
Category : Music
Languages : en
Pages : 12
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Book Description
A great virtuoso showpiece.
