Effects of Osteoporosis and Drugs on Bone Biomechanics PDF Download
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Author: Anne-Marie Bagnall
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Anne-Marie Bagnall
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Abdelwahed Barkaoui
Publisher: BoD – Books on Demand
ISBN: 1837680140
Category : Technology & Engineering
Languages : en
Pages : 157
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Book Description
Dive into the intricate realm of osteoporosis through the lens of biomechanics with Biomechanical Insights into Osteoporosis. This pioneering volume offers a comprehensive exploration of this debilitating condition, providing an in-depth understanding of its biomechanical foundations and implications. Osteoporosis, characterized by reduced bone mineral density and heightened susceptibility to fractures, stands as a global health challenge. This book brings together leading experts in the field, who rigorously analyze the multifaceted aspects of osteoporosis, offering invaluable knowledge for researchers, clinicians, and students alike. Key Highlights: •Biomechanical Foundations: Gain profound insights into the biomechanical basis of bone fractures and fracture osteosynthesis in small animals. Explore the fundamental principles that shape our understanding of osteoporotic biomechanics. •Non-Glucocorticoid Drug-Induced Osteoporosis: Investigate the mechanisms, risk factors, and therapeutic approaches for osteoporosis induced by medications other than glucocorticoids. •Vascular Remodeling and Bone Destruction: Discover the common pathogenetic links between vascular remodeling and bone tissue destruction in postmenopausal women with arterial hypertension. This holistic perspective illuminates bone health dynamics. •Genetic Targets and Future Directions: Explore promising genetic targets that have the potential to revolutionize osteoporosis treatment. Get a glimpse into the future of research and treatment strategies. •Biomarkers and Metabolism: Delve into the latest research progress surrounding bone mineral density and bone metabolism biomarkers, offering valuable insights into diagnostics and monitoring. •Impact of Diseases and Medical Treatments: Understand the intricate interplay between diseases and medical treatments on bone mineral density. Gain a comprehensive understanding of how various factors influence skeletal health. This book represents a significant milestone in deciphering the complexities of osteoporosis from a biomechanical perspective. Join us in this scientific journey to explore the fascinating facets of osteoporosis. Biomechanical Insights into Osteoporosis is an essential resource for anyone seeking a deeper understanding of this critical health issue and the biomechanical aspects that underlie it.
Author: Sarah Kathleen Easley
Publisher:
ISBN:
Category :
Languages : en
Pages : 210
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Book Description
Anti-fracture therapies for the treatment of osteoporosis have been shown clinically to reduce the incidence of fracture; however, standard clinical measurements of bone density cannot sufficiently explain these large reductions. Therefore, the overall goal of this research is to develop a better understanding of the mechanisms through which anti-fracture therapies improve bone strength -- a critical determinant of fracture risk -- which should lead to improved assessment of treatment efficacy. Combining the latest advances in micro-computed tomography and high-resolution micro-CT-based finite element modeling, we used repeated measures and parameter variations to isolate specific biomechanical effects of various bone characteristics that can be altered by disease and treatment. Specifically, we found that simulated microcavities in trabecular bone from a wide range of bone volume fraction and microarchitecture reduced the strength and altered the relationship between strength and bone volume fraction. While this effect was greater in low-density bone and when the microcavities were targeted to regions of high tissue strain, an appreciable biomechanical effect persisted for all types of bone. Since previous work with antiresorptive-treated canine bone did not find such an effect, questions remain regarding accurate representation of the morphology and micromechanics of actual resorption-induced cavities. Despite these uncertainties, our results provide new insight into the clinical relevance of stress risers caused by resorption cavities, suggesting that antiresorptive therapies may be most effective via mitigation of stress risers in a subset of patients with low bone volume fraction and high bone turnover. Studying vertebrae from treated rats revealed that any treatment-induced changes in intra-specimen variations in tissue mineralization, as detected by quantitative micro-CT, had a negligible biomechanical effect at the whole bone level and in isolated trabecular bone. Intra-specimen variations in tissue mineralization did have a role in general biomechanical behavior, but this role was remarkably uniform across the four different treatment groups: sham control, ovariectomized (OVX), OVX+PTH, and OVX+raloxifene. Finite element results showed that biomechanical treatment effects were dominated by treatment-induced changes in geometry and microarchitecture. This research also produced an efficient pre-clinical framework for characterizing bone quality which should provide considerable insight into the mechanisms of biomechanical effects in a broad range of bone research applications, including aging, diseases, and pharmaceutical and genetic therapy. The approach takes advantage of the hierarchical structure of bone by evaluating the most biomechanically relevant characteristics at each physical scale to isolate the source of bone quality effects and prescribing subsequent analysis only when such effects are found. Using this framework, we found that neither ovariectomy nor PTH treatment had a net effect on bone quality of rat vertebrae during compressive loading suggesting that the observed changes in vertebral strength were primarily due to changes in bone quantity. In closure, this dissertation research has increased knowledge regarding the mechanisms through which osteoporosis therapies improve bone strength without appreciably increasing bone mass. Further, it provides new methods for pre-clinical assessment of treatment efficacy. This dissertation also outlines areas of research to further advance our understanding of the effects of disease and drug therapies on bone biomechanics in human bone.
Author: Matthew J. Silva
Publisher: Springer Science & Business Media
ISBN: 3642180531
Category : Technology & Engineering
Languages : en
Pages : 261
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Book Description
The focus of this book is on mechanical aspects of skeletal fragility related to aging and osteoporosis. Topics include: Age-related changes in trabecular structure and strength; age-related changes in cortical material properties; age-related changes in whole-bone structure; predicting bone strength and fracture risk using image-based methods and finite element analysis; animal models of osteoporosis and aging; age-related changes in skeletal mechano responsiveness; exercise and physical interventions for osteoporosis.
Author: Hideaki E. Takahashi
Publisher: Springer Nature
ISBN: 9811656134
Category : Medical
Languages : en
Pages : 569
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Book Description
This edited book describes what fragile bone is, how the condition is assessed, and how it can be treated. It is intended for multi-professional trainees and practitioners in health and social care fields who care for and treat the elderly. Chapters within the book provide the latest advances in cell and molecular biology, morphology, radiology, and the biomechanics of bone in health and disease. The basic concept of “Remodeling” and “Modeling” is described for better understanding of the mechanisms of osteoporosis. Methods of identifying and assessing osteoporosis are described, as are risk factors for bone fracture and non-unions. Furthermore, the effects of various drugs used to treat osteoporosis at both material and structural levels of bone and their cost effectiveness are described. Operative treatments for fracture that maintain or improve the quality of life of patients are included Treatment of Osteoporotic Fracture and Systemic Skeletal Disorders attempts to provide a holistic and translational view of the pathogenesis and treatment of osteoporosis and some other musculoskeletal diseases, with an overview of treatment modalities in various clinical settings.
Author: Eric J. Bieber
Publisher: Cambridge University Press
ISBN: 1107040396
Category : Medical
Languages : en
Pages : 1127
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Book Description
Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
Author: Ignac Fogelman
Publisher: Springer
ISBN: 3642024009
Category : Medical
Languages : en
Pages : 1029
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Book Description
This book, written by authors with national and international reputations in the field, covers all aspects of radionuclide and hybrid bone imaging. Introductory sections present the basic science and consider the current status and limitations of conventional radiological techniques. The underlying principles of PET-CT and SPECT-CT are carefully explained, and the value of different PET and SPECT tracers, assessed. The role of single- and dual-modality approaches in the imaging of benign bone diseases and malignancies is then discussed in detail in a series of well-illustrated chapters. The pathologies addressed include metabolic bone disease, arthritis, bone and joint infections, primary bone and soft tissue tumors, and metastases from breast and prostate cancer. A further section considers the role of bone scintigraphy in the pediatric patient, and the closing chapters focus on miscellaneous subjects, including bone densitometry and radionuclide targeted therapy.
Author: Eric S. Orwoll
Publisher: Academic Press
ISBN: 0080923461
Category : Medical
Languages : en
Pages : 764
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Book Description
Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. Brings together more eminent investigators and clinicians to interpret developments in this growing field Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy There is no book on the market that covers osteoporosis in men as comprehensively as this book
Author: John D. Currey
Publisher: Princeton University Press
ISBN: 1400849500
Category : Science
Languages : en
Pages : 453
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Book Description
This is a comprehensive and accessible overview of what is known about the structure and mechanics of bone, bones, and teeth. In it, John Currey incorporates critical new concepts and findings from the two decades of research since the publication of his highly regarded The Mechanical Adaptations of Bones. Crucially, Currey shows how bone structure and bone's mechanical properties are intimately bound up with each other and how the mechanical properties of the material interact with the structure of whole bones to produce an adapted structure. For bone tissue, the book discusses stiffness, strength, viscoelasticity, fatigue, and fracture mechanics properties. For whole bones, subjects dealt with include buckling, the optimum hollowness of long bones, impact fracture, and properties of cancellous bone. The effects of mineralization on stiffness and toughness and the role of microcracking in the fracture process receive particular attention. As a zoologist, Currey views bone and bones as solutions to the design problems that vertebrates have faced during their evolution and throughout the book considers what bones have been adapted to do. He covers the full range of bones and bony tissues, as well as dentin and enamel, and uses both human and non-human examples. Copiously illustrated, engagingly written, and assuming little in the way of prior knowledge or mathematical background, Bones is both an ideal introduction to the field and also a reference sure to be frequently consulted by practicing researchers.
Author: Margareta Nordin
Publisher:
ISBN: 9781975229856
Category : Human mechanics
Languages : en
Pages : 0
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Book Description
"It is with great pleasure that we present the Fifth Edition of Basic Biomechanics of the Musculoskeletal System (BBMS). BBMS is now translated to eight languages, from English to Cantonese, Dutch, Greek, Japanese, Korean, Portuguese, Spanish, and Taiwanese"--
