Effects of Dental Monomeric Resins on Functions of Odontoblasts in Vitro PDF Download
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Author: Somjin Ratanasathien
Publisher:
ISBN:
Category :
Languages : en
Pages : 390
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Author: Somjin Ratanasathien
Publisher:
ISBN:
Category :
Languages : en
Pages : 390
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Author: Louis H. Berman
Publisher: Elsevier Health Sciences
ISBN: 032367304X
Category : Medical
Languages : en
Pages : 1092
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Book Description
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Dentistry** Stay up on the latest research and techniques in endodontics with Cohen's Pathways of the Pulp, 12th Edition. Written by a team of internationally renowned experts and trusted for more than 40 years, this definitive guide covers the science, theory, and practice of endodontics. Full color illustrations and detailed radiographs guide readers through each step of endodontic care — from diagnosis and treatment planning to proven techniques for managing pulpal and periapical diseases. This new twelfth edition also boasts the very latest evidence-based research and techniques, reorganized and condensed chapters, plus other features designed to help you locate important information quickly and easily. Complete with access to Expert Consult, it's everything you need to stay ahead in the field of endodontics. - Extensive illustration collection includes over 2,000 full-color photos, line art, and radiographs to clearly demonstrate core concepts and reinforce the essential principles and techniques of endodontics. - Video clips and case studies demonstrate key procedures such as palpation of the masseter muscle, introsseous anesthesia with the X-tip system, dentin hypersensitivity, and more. - Diverse and respected contributor pool includes experts from many national- and international-based dental education programs. - NEW! Updated content and new images incorporate the most recent developments in research and clinical endodontic techniques. - NEW! Additional topics cover pulp biology, pathobiology, diagnosis, treatment planning, pain control, isolation, access, cleaning and shaping, obturation, restoration, assessment of outcomes, emergencies and surgery. Each online topic comes with assigned reading lists, a PowerPoint lecture, written lesson objectives, and example exam questions. - NEW! Compliance with the Commission on Dental Accreditation Curriculum ensures that the needs of all dental programs are met. - NEW! Reorganized sections now divide chapters by those covering clinical endodontics, those covering the biological basis of endodontics, and chapters which detail endodontics in private practice to make content easier for both clinicians and students to navigate. - NEW! Condensed chapters remove unnecessary duplication of content across the text and make the physical text lighter and easier to use.
Author:
Publisher:
ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 816
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Author: Morgan A. Goss
Publisher:
ISBN:
Category :
Languages : en
Pages : 70
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Dentinogenesis is a complex process of dentin formation. It involves differentiation of odontoblasts, the cells that make dentin, and the formation of a unique extracellular matrix, known as dentin. Dentin is ultimately produced through the interaction of collagen fibers, non-collagenous proteins and hydroxyapatite (HA) crystals. Odontoblasts are cranial neural crest (CNC) ectomesenchymal derived cells. Trps1 is a novel transcription factor believed to play an important role in both tooth formation and the mineralization process. TRPS1 gene mutations are known to result in dental and skeletal abnormalities manifested in humans as tricho-rhino-phalangeal syndrome (TRPS) and Ambras syndrome. Trps1 expression varies throughout odontoblast development. Strongly expressed in preodontoblasts, Trps1 then decreases in mature secretory cells at onset of mineralization; thus its downregulation coincides with terminal differentiation of odontoblasts. Our laboratory recently demonstrated that sustained high expression of Trps1 in secretory odontoblasts represses secretion and mineralization of dentin matrix in vitro. However, the specific role Trps1 plays in dentinogenesis remains unclear. To better understand the function of Trps1 in odontoblast maturation, ex vivo tooth organ culture studies were performed. Trps1 knockout mice (KO) are perinatal lethal, therefore dentinogenesis has not been studied in these mice until now. Analyses were performed to define whether Trps1-deficiency affects odontoblast maturation and/or odontoblast function. We found that Trps1 KO mice were able to form differentiated odontoblasts, capable of secreting a predentin matrix. However, mature odontoblasts in Trps1 KO mice were unable to produce matrix vesicles, an important component that supports the mineralization process. Altered expression of several key osteogenic factors (Runx2, Sp7, TNAP) in Trps1 KO tooth organs revealed that Trps1 functions in both a cell autonomous and non-autonomous fashion in different areas of the developing molar. Furthermore, analyses of embryonic day 18.5 Trps1 KO molars revealed Trps1-deficienct mice exhibit a smaller first mandibular molar compared to WT, mimicking a dental phenotype seen in human patients affected with TRPS. Results of this project have provided first insight into the role of Trps1 in odontoblast maturation and allowed for better understanding of the molecular mechanisms of dentin formation.
Author: Gottfried Schmalz
Publisher: Springer Science & Business Media
ISBN: 3540777822
Category : Medical
Languages : en
Pages : 392
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Book Description
This book provides a comprehensive and scientifically based overview of the biocompatibility of dental materials. Up-to-date concepts of biocompatibility assessment are presented, as well as information on almost all material groups used in daily dentistry practice. Furthermore, special topics of clinical relevance (e.g,, environmental and occupational hazards and the diagnosis of adverse effects) are covered. The book will: improve the reader’s ability to critically analyze information provided by manufacturers supply a better understanding of the biocompatibility of single material groups, which will help the reader choose the most appropriate materials for any given patient and thus prevent adverse effects from developing provide insights on how to conduct objective, matter-of-fact discussions with patients about the materials to be used in dental procedures advise readers, through the use of well-documented concepts, on how to treat patients who claim adverse effects from dental materials feature clinical photographs that will serve as a reference when analyzing clinical symptoms, such as oral mucosa reactions.
Author: Giovanna Orsini
Publisher: Frontiers Media SA
ISBN: 2889199843
Category : Physiology
Languages : en
Pages : 248
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Book Description
Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by unique and specific collagenous (dentin, fibrillar cementum) and non-collagenous (enamel) highly mineralized extracellular matrices. Alveolar bone is another collagenous hard tissue that supports tooth stability and function through its close interaction with the periodontal ligament. Dental hard tissues are often damaged after infection or traumatic injuries that lead to the partial or complete destruction of the functional dental and supportive tissues. Well-established protocols are routinely used in dental clinics for the restoration or replacement of the damaged tooth and alveolar bone areas. Recent progress in the fields of cell biology, tissue engineering, and nanotechnology offers promising opportunities to repair damaged or missing dental tissues. Indeed, pulp and periodontal tissue regeneration is progressing rapidly with the application of stem cells, biodegradable scaffolds, and growth factors. Furthermore, methods that enable partial dental hard tissue repair and regeneration are being evaluated with variable degrees of success. However, these cell-based therapies are still incipient and many issues need to be addressed before any clinical application. The understanding of tooth and periodontal tissues formation would be beneficial for improving regenerative attempts in dental clinics. In the present e-book we have covered the various aspects dealing with dental and periodontal tissues physiology and regeneration in 6 chapters: 1. General principles on the use of stem cells for regenerating craniofacial and dental tissues 2. The roles of nerves, vessels and stem cell niches in tissue regeneration 3. Dental pulp regeneration and mechanisms of various odontoblast functions 4. Dental root and periodontal physiology, pathology and regeneration 5. Physiology and regeneration of the bone using various scaffolds and stem cell populations 6. Physiology, pathology and regeneration of enamel using dental epithelial stem cells
Author: Karen Sagomonyants
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages :
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Book Description
Odontoblast differentiation is dependent on multiple signaling molecules, including growth factors stored in the extracellular dentin matrix. Our previous studies have demonstrated that Fibroblast Growth Factor 2 (FGF2) exerted stage-specific effects on odontoblast differentiation in primary dental pulp cultures. FGF2 stimulated differentiation of functional odontoblasts expressing high levels of Dmp1 from early progenitors but inhibited the terminal differentiation of functional odontoblasts to fully differentiated odontoblasts expressing high levels of Dspp. These stimulatory effects involved activation of FGFR and ERK1/2, and increased levels of expression of Bmp2, Runx2, and Osx (components of BMP signaling) suggesting the involvement of BMP signaling in FGF2-induced Dspp expression. Therefore, the overall goal of the studies outlined in this thesis was to examine the role of BMP signaling in stimulatory effects of FGF signaling on odontoblast differentiation of dental pulp cells. We showed that BMP2 did not affect the extent of mineralization but rapidly (within ~12-24 hrs) stimulated expression of Dspp and intensity of DSPP-Cerulean transgene in a concentration-dependent manner without affecting the percentage of DSPP-Cerulean+ odontoblasts. In contrast to Dspp, BMP2 rapidly (within ~24-48 hrs) decreased expression of Dmp1, Bsp, DMP1-mCherry, and BSP-GFP in a concentration-dependent manner. Inhibition of the BMP and FGF signaling pathways by noggin and SU5402, respectively, did not have marked effects on the extent of mineralization but decreased expression of Dspp stimulated by these growth factors. These inhibitory effects were long-lasting and observed up to 14 days after removal of the growth factors. Additional experiments in primary bone marrow stromal cells cultures demonstrated that early and limited exposure to BMP2 did not affect mineralization but decreased expression of Dmp1, Bsp, and respective transgenes. Taken together, our results demonstrated that activation of the canonical BMP signaling pathway during the proliferation phase of in vitro growth resulted in significant increases in the expression of Dspp, and these increases were mediated via reciprocal interaction of the BMP and FGF signaling pathways. These data will further elucidate the perspectives of using both FGF2 and BMP2 in dentin regeneration applications.
Author: Imad About
Publisher: Springer Nature
ISBN: 3030809323
Category : Medical
Languages : en
Pages : 233
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Book Description
This book is a comprehensive guide to BiodentineTM, an innovative biocompatible and bioactive material based on pure tricalcium silicate that can permanently replace dentin and can also serve as a temporary enamel substitute. Although BiodentineTM has been widely used across the world for the past decade, this is the first book to be devoted to its properties, interactions with the soft and hard tissues, and its multiple clinical applications. The coverage encompasses applications in primary and permanent teeth, in specialties as diverse as restorative dentistry, endodontics, paediatric dentistry, dental traumatology, and prosthetic dentistry. BiodentineTM application both in vital pulp therapy and endodontic procedures is illustrated and clinical step by step protocols are provided. The book provides a detailed update on BiodentineTM use to preserve the pulp vitality in direct/indirect pulp capping, pulpotomy and irreversible pulpitis treatment. It also details BiodentineTM use for non-vital teeth treatment in indications such as root/furcation perforation repair, apexification as well as in regenerative endodontic procedures. BiodentineTM: Properties and Clinical Applications will be a rich source of guidance and information for all dentists as well as dental students and academics.
Author: Karen Sagomonyants
Publisher:
ISBN:
Category :
Languages : en
Pages : 818
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Author: Tatsuya Ishikawa
Publisher: Quintessence Publishing (IL)
ISBN:
Category : Medical
Languages : en
Pages : 206
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Book Description
