Early Features of the Bone-implant Interface in Hip Arthroplasty PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Early Features of the Bone-implant Interface in Hip Arthroplasty PDF full book. Access full book title Early Features of the Bone-implant Interface in Hip Arthroplasty by Jan de Waal Malefijt. Download full books in PDF and EPUB format.
Author: Jan de Waal Malefijt
Publisher:
ISBN:
Category :
Languages : en
Pages : 175
Get Book Here
Book Description
Author: Jan de Waal Malefijt
Publisher:
ISBN:
Category :
Languages : en
Pages : 175
Get Book Here
Book Description
Author: Charles Rivière
Publisher: Springer Nature
ISBN: 3030242439
Category : Medical
Languages : en
Pages : 346
Get Book Here
Book Description
This open access book describes and illustrates the surgical techniques, implants, and technologies used for the purpose of personalized implantation of hip and knee components. This new and flourishing treatment philosophy offers important benefits over conventional systematic techniques, including component positioning appropriate to individual anatomy, improved surgical reproducibility and prosthetic performance, and a reduction in complications. The techniques described in the book aim to reproduce patients’ native anatomy and physiological joint laxity, thereby improving the prosthetic hip/knee kinematics and functional outcomes in the quest of the forgotten joint. They include kinematically aligned total knee/total hip arthroplasty, partial knee replacement, and hip resurfacing. The relevance of available and emerging technological tools for these personalized approaches is also explained, with coverage of, for example, robotics, computer-assisted surgery, and augmented reality. Contributions from surgeons who are considered world leaders in diverse fields of this novel surgical philosophy make this open access book will invaluable to a wide readership, from trainees at all levels to consultants practicing lower limb surgery
Author: Jan de Waal Malefijt
Publisher:
ISBN:
Category :
Languages : en
Pages : 175
Get Book Here
Book Description
Author: Ian D. Learmonth
Publisher: Springer Science & Business Media
ISBN: 1447104773
Category : Medical
Languages : en
Pages : 42
Get Book Here
Book Description
This book incorporates the experience of numerous experts who explore contemporary opinion of how best to rationalise and optimise the interfaces at total hip replacement to provide the most favourable and durable results. The survival of a total hip replacement depends principally on the enduring integrity of the fixation interfaces and of the articular interface. The design of the stem and the material properties of cement largely determine the state of the component-cement inter face, while the bone-cement interface is significantly influenced by both mechanical and biological factors. The surface finish and shape of cementless implants are designed to preserve the integrity of biological fixation (osseo-integration) at the bone-component interface. Once again, both mechanical and biological factors have to be considered, while bioactive coatings accelerate bone ongrowth. Metal-on-polyethylene is the most widely used articular interface. However, it has been suggested that wear of polyethylene is one of the major factors contributing to failure of total hip replacements. The increasing prevalence of total hip replacement in younger patients has stimulated the investigation of alternative, more durable couples -including ceramic-polyethylene, ceramic-ceramic and metal-on-metal. Modularity provides greater intra-operative flexibility, but each new modular interface introduces new mechanisms of failure. These need to be anticipated and appropriate measures taken to avoid them. Hopefully this book will provide a better understanding of the factors that contribute to stable interfaces and long-term survival of total hip arthroplasty.
Author: John Older
Publisher: Springer Science & Business Media
ISBN: 1447118111
Category : Medical
Languages : en
Pages : 343
Get Book Here
Book Description
An update on current knowledge is given for surgeons and researchers involved in implant surgery and the development of implant arthroplasty. The contributions come from a distinguished international faculty of orthopaedic surgeons, biologists and engineers. They examine the junctional tissues between an implant and the bone in joint replacement surgery. The factors that influence junctional tissues and so affect the life-span of the implant are thoroughly discussed. These include: detailed data on the microscopy of the junctional tissues, the mechanical properties of cement, and the architecture of bone and implant design. The discussions following each contribution give meaningful insight into background information and the controversial aspects of surgical implants.
Author: Raj K. Sinha
Publisher: CRC Press
ISBN: 0824743822
Category : Medical
Languages : en
Pages : 441
Get Book Here
Book Description
Hip Replacement offers useful strategies to choose the appropriate biomaterials and implant structure avoid complications in hip replacement surgery analyze the bone-biomaterial interface perform difficult hip reconstructions track in vivo performance of hip prosthetics inhibit implant loosening and the formation of wear debris classify acetabular defects for surgical revisions Providing nearly 200 figures, pictures, and micrographs to clarify surgical procedures, Hip Replacement is a timely and state-of-the-art guide for orthopaedic and hip replacement surgeons; geriatricians; biomedical, biomaterials, and chemical engineers and bioengineers; physical, materials, biological, and polymer scientists; and upper-level undergraduate and graduate students in these disciplines.
Author: Hugh U. Cameron
Publisher: St. Louis ; Toronto : Moseby
ISBN:
Category : Medical
Languages : en
Pages : 408
Get Book Here
Book Description
Author: Mehdi Amirhosseini
Publisher: Linköping University Electronic Press
ISBN: 9176852385
Category :
Languages : en
Pages : 41
Get Book Here
Book Description
Aseptic loosening is the main cause of failure of orthopedic prostheses. With no pharmaceuticals to prevent or mitigate periprosthetic bone degradation, a surgery to replace the loose implant with a new one is the only choice to restore patients’ function. Most studies on mechanisms for aseptic loosening investigate wear debris particle-induced osteolysis. However, pathological loading conditions around unstable implants can also trigger osteoclast differentiation and bone loss. In the first study, global gene expression changes induced by mechanical instability of implants, and by titanium particles were compared in a validated rat model for aseptic loosening. Microarray analysis showed that similar signaling pathways and gene expression patterns are involved in particle- and instability-induced periprosthetic osteolysis with an early onset innate immune response as a hallmark of osteolysis induced by mechanical instability. Further, effects of potential therapeutics on restriction of excessive osteoclast differentiation were evaluated. Wnt signaling pathway is known to regulate bone remodeling. In the second study, effects of inactivation of glycogen synthase kinase 3 beta (GSK-3?), a negative regulator of canonical Wnt signaling, on instability-induced periprosthetic osteolysis were examined using our rat model for aseptic loosening. Inhibition of GSK-3? led to a decrease in osteoclast numbers in the periprosthetic bone tissue exposed to mechanical instability while osteoblast perimeter showed an increase. This was accompanied by higher bone volume fraction (BV/TV) in animals treated with the GSK-3? inhibitor. In the third study, potential beneficial effects of two selective inhibitors of cyclindependent kinase 8/19 (CDK8/19) on bone tissue were evaluated. CDK8/19 is a Mediator complex-associated transcriptional regulator involved in several signaling pathways. CDK8/19 inhibitors, mainly under investigation as treatments for tumors, are reported to enhance osteoblast differentiation and bone formation. We show in this study, for the first time, that inhibition of CDK8/19 led to marked suppression of osteoclast differentiation from bone marrow macrophages in vitro through disruption of the RANK signaling. In mouse primary osteoblasts downregulation of osteopontin mRNA, a negative regulator of mineralization, together with increased alkaline phosphatase activity and calcium deposition indicated that osteoblast mineralization was promoted by CDK8/19 inhibition. Moreover, local administration of a CDK8/19 inhibitor promoted cancellous bone regeneration in a rat model for bone healing. These studies contribute to better understanding of mechanisms behind mechanical instability-induced periprosthetic osteolysis and propose potential therapeutics to restrict bone loss with effects on both osteoclasts and osteoblasts.
Author: Charles A. Engh
Publisher: Slack
ISBN:
Category : Medical
Languages : en
Pages : 282
Get Book Here
Book Description
Author: Theofilos Karachalios
Publisher: Springer Science & Business Media
ISBN: 1447154096
Category : Medical
Languages : en
Pages : 342
Get Book Here
Book Description
Total joint arthroplasty is an effective surgical procedure for end-stage osteoarthritis of major joints with satisfactory long term clinical outcome. A large and growing number of arthroplasties are performed annually worldwide and a great number of orthopaedic surgeons are practicing arthroplasty surgery as their main surgical activity. The biological behavior of the bone-implant interface is crucial for the long term survival of the artificial joint. All factors which have a positive or negative effect on the interface are of great interest for those practicing arthroplasty surgery. Basic scientists and the industry are continuously searching for new implant fixation mechanisms and improved materials. There is an accumulation of a great amount of basic science data (both biological, material and mechanical) related to the incorporation or loosening of the bone-implant interface. However, basic science data does not always translate to satisfactory clinical application, and orthopaedic practitioners often wonder which piece of information is clinically useful. A further problem is that basic scientists often speak their own scientific language and may not fully appreciate common clinical practice needs. In this textbook the biological and mechanical mechanisms of implant incorporation and loosening will be presented. All new data concerning materials and methods for incorporation enhancement will be critically analyzed. Data useful for clinical application will be stressed. Orthopaedic Surgeons will find information which will improve their clinical practice and basic scientists will be helped to understand and appreciate clinical needs.
