Dissecting the Molecular Mechanisms of Notch Signaling PDF Download
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Author: Jianlin Chu
Publisher:
ISBN:
Category :
Languages : en
Pages : 208
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Book Description
Author: Jianlin Chu
Publisher:
ISBN:
Category :
Languages : en
Pages : 208
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Book Description
Author: Tilman Borggrefe
Publisher: Springer
ISBN: 3319895125
Category : Science
Languages : en
Pages : 417
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Book Description
This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.
Author: American Association for Cancer Research
Publisher: Coe Truman International, LLC
ISBN: 0463372727
Category :
Languages : en
Pages : 2656
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Book Description
American Association for Cancer Research 2019 Proceedings: Abstracts 2749-5314 - Part B
Author: Malgorzata Kloc
Publisher: John Wiley & Sons
ISBN: 111849282X
Category : Science
Languages : en
Pages : 459
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Book Description
Frogs from the genus Xenopus have long been used as model organisms in basic and biomedical research. These frogs have helped unlock key fundamental developmental and cellular processes that have led to important scientific breakthroughs and have had practical application in embryology, cancer research and regenerative medicine. Xenopus Development is a vital resource on the biology and development of these key model organisms, and will be a great tool to researchers using these frogs in various disciplines of biological science. Xenopus Development is divided into four sections, the first three highlight key processes in Xenopus development from embryo to metamophosis. These sections focus on the cellular processes, organogenesis and embryo development. The final section highlights novel techniques and approaches being used in Xenopus research. Providing thorough and detailed coverage, Xenopus Development, will be a timely and welcome volume for those working in cell and molecular biology, genetics, developmental biology and biomedical research. Provides broad overview of the developmental biology of both Xenopus laevis and Xenopus tropicalis Explores cellular to systems development in key biomedical model organisms Timely synthesis of the field of Xenopus biology Highlights key biomedical and basic biological findings unlocked by Xenopus
Author: Charles J. Yeo
Publisher: Elsevier Health Sciences
ISBN: 0323531776
Category : Medical
Languages : en
Pages : 2599
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Book Description
For more than 60 years, Shackelford's Surgery of the Alimentary Tract has served as the cornerstone reference in this fast-moving field. With comprehensive coverage of all aspects of GI surgery, the 8th Edition, by Drs. Charles J. Yeo, Steven R. DeMeester, David W. McFadden, Jeffrey B. Matthews, and James W. Fleshman, offers lavishly illustrated, authoritative guidance on endoscopic, robotic, and minimally invasive procedures, as well as current medical therapies. Each section is edited by a premier authority in GI surgery; chapters reflect key topics and are written by a "who's who" of international experts in the field. It's your one-stop resource for proven, systematic approaches to all relevant adult and pediatric GI disorders and operations - Features an abundance of beautifully detailed intraoperative and laparoscopic photographs, as well as radiographs and line drawings, to enhance and clarify the text. - Presents essential information, such as lists of differential diagnoses, in tabular format for quick reference. - Discusses recent, major advances in minimally invasive surgery and robotic surgery, personalized therapy based on genomics and proteomics, and new pharmacologic treatments of various GI diseases. - Includes all-new information on laparoscopy for rectal cancer, sacral nerve stimulation for incontinence and constipation, management of Crohn's disease and ulcerative colitis, advances in immunosuppression for transplant patients, and new therapies for inflammatory bowel disease. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Author: Jonathan Soboloff
Publisher: CRC Press
ISBN: 149870509X
Category : Medical
Languages : en
Pages : 258
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Book Description
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1436
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Book Description
Author: Anthony R. Bellvé
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 400
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Book Description
Molecular Mechanisms in Cellular Growth and Differentiation describes the cellular differentiation and development. It emphasizes the pattern formation, specifically the genesis of spatial relationships, among the parts of a vertebrate or invertebrate organism, embryonic or adult. Organized into five parts, this book deals with the major steps leading from growth factor-receptor interactions, through transduction and modulation mechanisms, to proliferative response. It also discusses the relation of growth factors and their receptors to oncogenes and to protooncogenes. It also elucidates the r ...
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 924
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Author: John Smith Dexter
Publisher:
ISBN:
Category : Animals
Languages : en
Pages : 58
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Book Description
