Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases PDF Download
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Author: Honghui Zhou
Publisher: John Wiley & Sons
ISBN: 1119289211
Category : Medical
Languages : en
Pages : 513
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Book Description
Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders.
Author: Honghui Zhou
Publisher: John Wiley & Sons
ISBN: 1119289211
Category : Medical
Languages : en
Pages : 513
Get Book Here
Book Description
Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders.
Author: John W. D. McDonald
Publisher: John Wiley & Sons
ISBN: 1405140127
Category : Medical
Languages : en
Pages : 643
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Book Description
Traditional textbooks in this field have emphasized the basic sciences of pathology, biochemistry and physiology. Evidence-based Gastroenterology and Hepatology covers all the major diseases of the gastrointestinal tract and liver, utilizing clinical epidemiology to present the strongest and most current evidence for interventions. This second edition is edited and written by leading gastroenterologists from around the world, each chapter summarizes the evidence so that better informed decisions will be made about which treatments to offer to patients. It provides practising Gastroenterologists and Surgeons with clear information regarding the diagnosis and treatment of pancreatic diseases, giving clear evidence and experience-based material that is immediately relevant to clinical practice. Also contains a list of recommended reading at the end of each chapter. Take a look at up to date information at www.evidbasedgastro.com
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1292
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Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 506
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Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 312
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Book Description
Author: Jerome D. Waye
Publisher: John Wiley & Sons
ISBN: 047098693X
Category : Medical
Languages : en
Pages : 668
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Book Description
First Edition - Winner of 2004 BMA Medical Book Competitionin Gastroenterology A state-of-the-art reference guide covering all aspects ofthe performance, technical and clinical background tocolonoscopy The second edition of this prize winning book is written by someof the world’s foremost experts in the field of colonoscopyand colonic imaging. Every chapter has been updated and 5 newchapters have been added to include the latest information andadvances in the field of colonoscopy: Capsule Colonoscopy Narrow Band Imaging Confocal Endomicroscopy Endoscopic Submucosal Dissection in the Colon New Colonoscopes and Assist Devices Drawing on the vast experience of the authors it coversevery area of medicine that impacts on colonoscopy, includingvirtual colonography, pathology, techniques for pediatric and adultprocedures, and legal aspects concerning colonoscopy. The book is focused on patient care, and provides explanationson how to perform the procedure effectively and make the bestoutcome for your patients. It serves as a detailed manual ofprocedures, extensively illustrated with diagrams and photographsand there is an accompanying DVD with multiple demonstrations oftechnique. This is an invaluable compendium on all aspects of colonoscopy,suitable for use by every grade of practitioner world-wide and anessential reference book for allestablishments with an endoscopyfacility.
Author: British Library. Document Supply Centre
Publisher:
ISBN:
Category : Conference proceedings
Languages : en
Pages : 870
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Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 2432
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Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author: Christopher C. Thompson
Publisher: Springer Science & Business Media
ISBN: 1441917101
Category : Medical
Languages : en
Pages : 244
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Book Description
To date, diet programs and medical therapies for the treatment of obesity have had limited success. Bariatric surgery, however, provides a means of effective weight loss for many of those with morbid obesity. Most of these weight loss procedures are performed with a variety of techniques that continue to evolve. Each technique is associated with unique challenges and complications and it is important for the clinician to be knowledgeable about the endoscopic management of these patients. Additionally, as endoscopic technology evolves it may offer more than just the diagnosis and treatment of complications. Endoscopic therapy may soon allow less invasive bariatric revision procedures as well as a variety of primary obesity therapies for various patient populations. Bariatric Endoscopy reviews the management of obesity, normal post-surgical anatomy, endoscopic and medical management of post-surgical complications, and future endoscopic therapies for obesity management. Organized into five sections, the volume covers an obesity overview, traditional therapy, endoscopy and the bariatric patient, medical management of post-surgical complications, and the future role of endoscopy in obesity management. Detailed illustrations are also provided for surgical procedures, complications and obesity management chapters. Authored by authorities in the field, Bariatric Endoscopy is an indispensible tool for the gastroenterologist or surgical endoscopist as they care for patients with complicated bariatric issues.
Author: Dmitry Garbuzenko
Publisher: BoD – Books on Demand
ISBN: 1839681497
Category : Medical
Languages : en
Pages : 96
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Book Description
The book "Pancreatitis" is devoted to the actual and, in some cases, controversial and unresolved problems associated with acute and chronic pancreatitis. The material presented in it will be of interest to anyone who considers pancreatology their specialty.
