Développements méthodologiques pour l'étude des systèmes membranaires par résonance magnétique nucléaire PDF Download
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Author: Stéphane Massou
Publisher:
ISBN:
Category :
Languages : fr
Pages : 126
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Author: Stéphane Massou
Publisher:
ISBN:
Category :
Languages : fr
Pages : 126
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Book Description
Author: Olivier Wattraint
Publisher:
ISBN:
Category :
Languages : fr
Pages : 240
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Author: BICH-THUY.. DOAN
Publisher:
ISBN:
Category :
Languages : fr
Pages : 239
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Book Description
CE TRAVAIL CONCERNE LE DEVELOPPEMENT DE L'ASPECT METHODOLOGIQUE DE LA SPECTROSCOPIE RMN 2D D'UNE PART, DANS LE BUT D'ANALYSER LA COMPOSITION DE POLYAROMATIQUES DE MELANGES PETROLIERS DE GAZOLES, ET D'AUTRE PART, POUR L'ETUDE DES MILIEUX VIVANTS PAR RMN 2D ET 2D LOCALISEE. CES DEUX DOMAINES PEUVENT EN EFFET BENEFICIER D'OUTILS RMN ANALOGUES POUR ETRE EXPLORES. DANS LE CAS DES MELANGES PETROLIERS, LE PROBLEME PRINCIPAL DE L'ANALYSE A ETE DE TRIER L'INFORMATION PRESENTE AFIN D'EN TIRER DES IDENTIFICATIONS. POUR CE FAIRE, COMPTE TENU DU TYPE DE MOLECULES POLYAROMATIQUES PETROLIERES QUI SONT DES SYSTEMES DE SPINS MULTI-QUANTA CARACTERISTIQUES, NOUS AVONS ETUDIE DIFFERENTES SEQUENCES HOMONUCLEAIRES TELLES LES SEQUENCES DE FILTRES MULTI-QUANTA (TQF-COSY, E-COSY) ET LA SEQUENCE TOCSY. L'ETUDE DE CETTE DERNIERE A CONDUIT A UNE METHODE DE CARACTERISATION DES COMPOSES POLYAROMATIQUES; D'UNE PART, A PARTIR DES EMPREINTES 2D SPECIFIQUES DES SYSTEMES DE SPINS ET D'AUTRE PART, A PARTIR DES COURBES D'EVOLUTION DES INTENSITES DE PICS DE CORRELATION TOCSY EN FONCTION DU TEMPS DE MELANGE M, COURBES SPECIFIQUEMENT CORRELEES A UN SYSTEME DE SPIN PARTICULIER. PAR AILLEURS, NOUS AVONS MONTRE QU'IL ETAIT POSSIBLE DE QUANTIFIER LES PRODUITS IDENTIFIES. AINSI, NOUS AVONS PU PROCEDER A LEUR ANALYSE. DANS LE CAS DES MILIEUX VIVANTS, NOUS AVONS ADAPTE ET DEVELOPPE DES SEQUENCES 2D. NOTAMMENT, NOUS AVONS MONTRE L'INTERET D'UNE SEQUENCE 2D PHASEE: LA TOCSY POUR L'ETUDE DE MUSCLES DE SOURIS. EN OUTRE, NOUS AVONS MIS AU POINT LA PREMIERE SEQUENCE DE RMN 2D IN VIVO LOCALISEE (VOSY-COSY) APPLIQUEE CHEZ L'HOMME, UTILISANT LES TECHNIQUES DE GRADIENTS DE L'IMAGERIE POUR LA LOCALISATION ET CELLES DE LA SPECTROSCOPIE POUR CREER LA SEQUENCE. CELLE-CI PERMETTANT D'ETUDIER UNE ZONE PRECISE, LES PERSPECTIVES D'APPLICATIONS SONT PARTICULIEREMENT IMPORTANTES POUR EXPLORER LES MILIEUX VIVANTS
Author: ANJA.. BOCKMANN
Publisher:
ISBN:
Category :
Languages : fr
Pages : 277
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L'ANALYSE DES INTERACTIONS AVEC L'EAU EST UN MOYEN D'APPROCHE DE LA STRUCTURE ET DE LA DYNAMIQUE DES MACROMOLECULES BIOLOGIQUES. GRACE A DES DEVELOPPEMENTS RECENTS, LA RESONANCE MAGNETIQUE NUCLEAIRE EST DEVENUE UN OUTIL TRES PUISSANT POUR L'OBSERVATION DE CES INTERACTIONS. NOUS PROPOSONS DANS UN PREMIER CHAPITRE DE NOUVELLES METHODES QUE NOUS AVONS DEVELOPPEES POUR LE TRAVAIL DANS ET SURTOUT AVEC L'EAU. NOUS PRESENTONS LES SEQUENCES SELECTIVES SNURD, EAUSY ET WANTED QUI TIENNENT COMPTE DU PHENOMENE DE L'AMORTISSEMENT PAR RAYONNEMENT COHERENT QUI REND DELICATE L'OBSERVATION DE L'EAU A HAUT CHAMP MAGNETIQUE. LE DEUXIEME CHAPITRE PRESENTE L'APPLICATION DE L'EXPERIENCE PSEUDO-3D SNURD-TOCSY A L'ETUDE DE L'INFLUENCE DU THIOCYANATE SUR L'HYDRATATION DU BPTI. GRACE A NOTRE METHODE, NOUS AVONS PU METTRE EN EVIDENCE L'INFLUENCE DU SEL SUR LES VITESSES D'ECHANGE DES PROTONS LABILES ; L'IMPACT SUR LES TEMPS DE RESIDENCE DES MOLECULES D'EAU INTERNES SEMBLE, S'IL EST PRESENT, TRES FAIBLE. LE TROISIEME CHAPITRE TRAITE L'ANALYSE DES VITESSES D'ECHANGE DES PROTONS AMIDES DU DOMAINE DE LIAISON A L'ADN DE LA PROTEINE FRUR. LE DEVELOPPEMENT D'UNE EXPERIENCE HETERONUCLEAIRE SELECTIVE A LA FREQUENCE DE L'EAU SNURD-HSQC A PERMIS L'EVALUATION SEMI-QUANTITATIVE DES VITESSES D'ECHANGE RAPIDES. UNE COMPARAISON DES VITESSES D'ECHANGE OBTENUES AVEC LA PROBABILITE POUR CHAQUE PROTON AMIDE DE FORMER UNE LIAISON HYDROGENES MONTRE UNE BONNE CORRELATION. DANS LE QUATRIEME CHAPITRE NOUS PRESENTONS UNE NOUVELLE METHODE QUI PERMET LA DETERMINATION QUANTITATIVE DES VITESSES D'ECHANGE COMPRISES ENTRE QUELQUES DIZAINES ET CENTAINES DE MILLISECONDES. CETTE EXPERIENCE SELECTIVE A LA FREQUENCE DE L'EAU UTILISE LE PRINCIPE DE MESURE DE DIFFUSION POUR DETERMINER LES TEMPS DE RESIDENCE. NOUS AVONS APPLIQUE CETTE SEQUENCE A L'EVALUATION DES VITESSES D'ECHANGE DES PROTONS IMINO D'UN 16MERE D'ADN. LES RESULTATS OBTENUS SONT EN BON ACCORD AVEC LES MESURES DE TRANSFERT D'AIMANTATION PAR LA METHODE CLASSIQUE BIDIMENSIONNELLE
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309388708
Category : Medical
Languages : en
Pages : 201
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Book Description
Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications.
Author: Ashraf Brik
Publisher: John Wiley & Sons
ISBN: 3527346600
Category : Science
Languages : en
Pages : 626
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Book Description
How to synthesize native and modified proteins in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins. Comprehensive in scope, this important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL). It includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization. In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also discuss the synthetic challenges that remain to be addressed. This unmatched resource: Contains valuable insights from the pioneers in the field of chemical protein synthesis Presents proven synthetic approaches for a range of protein families Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.
Author:
Publisher: Academic Press
ISBN: 0128172258
Category : Medical
Languages : en
Pages : 254
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Book Description
Mitochondrial Neuropathies, Volume 146, brings together experts in a range of diseases that damage the nervous system to present the role of mitochondrial dysfunction in their particular field, with this new release focusing on Mitochondrial dysfunction in Alzheimer's Disease, HIV and the mitochondrial: immune interface in the CNS, The Impact of mitochondrial damage in HIV-induced peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of chemotherapy-induced peripheral neuropathy, Disorders of mitochondrial biogenesis in peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of diabetic neuropathy, Manipulating mitochondria to treat peripheral neuropathy, and DCA therapy - the yin and yang of mitochondrial activation. - Contains contributions from a diverse group of experts - Presents a timely resource that brings together different fields to highlight a common pathogenic mechanism - Focuses on the role of mitochondria in diverse neuropathies
Author: Michael G. Kaplitt
Publisher: Elsevier
ISBN: 0080454372
Category : Science
Languages : en
Pages : 372
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Book Description
Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis.* Presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells* Discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis* Includes "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use
Author: Israel Silman
Publisher: CRC Press
ISBN: 9781841840758
Category : Science
Languages : en
Pages : 854
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Book Description
Providing a cutting-edge profile of research progress in this important field of study, Cholinergic Mechanisms: Function and Dysfunction contains a compilation of the proceedings of the Eleventh ISCM, held in St. Moritz, May 2002. Bringing together 250 contributors from 30 countries, the book presents a comprehensive picture of the cholinergic field. It provides a survey of current understanding of molecular, pharmacological, toxicological, behavioral, and clinical aspects of the cholinergic system. This volume offers a state-of-the-art account of progress in the field from the molecule in the test tube through the cell and the synapse, to the organism and the patient.
Author: World Bank
Publisher: World Bank Publications
ISBN: 0821385631
Category : Social Science
Languages : en
Pages : 114
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Book Description
This report provides the most comprehensive and rigorous analysis of Iraqi income and expenditure in several decades. The report makes extensive use of the Iraq Household Socio-Economic Survey, the first nationwide income and expenditure survey since 1988. IHSES data is complemented income and expenditure data from a wide range of other measures of living standards, allowing us to analyze living standards in a holistic way. The analysis presented here was performed with two main goals first, to inform the Government s Poverty Reduction Strategy; and second, to serve as a baseline for future assessments of changes in living standards and the identification of critical issues for deeper examination. Iraqi living standards have two unusual characteristics. First, they have fallen over the past generation. Second, they feature surprisingly little inequality. These characteristics are both rooted in Iraq s recent history of authoritarian government, war, military occupation, insurgency, and civil strife leading to infrastructure destruction and population displacement. There have been few opportunities for individuals to prosper from professional or entrepreneurial activities. Decades of neglected investment have resulted in deterioration of social services and economic infrastructure. Consequently, individuals have lacked capabilities to prosper and an investment climate conducive to prosperity. School enrollment and life expectancy have declined. Extremely low returns to education reflect the combination of poor educational quality and lack of employment opportunities. In terms of economic infrastructure, access to reliable electricity and water, and even access to paved roads are low, are further reflections of decades of neglect. While the upper end of the distribution has been pulled down by a lack of opportunities, the lower end has been supported by direct government provision of food. The Public Distribution System (PDS) provides 85 percent of food needs. While PDS has been useful as a safety net for the poor and the vulnerable, the system is expensive, inefficient, and fiscally risky. Indeed, PDS food rations account for a far greater share of public spending than does education or health. Going forward, Iraq faces two main challenges. First, although Iraq does not have to develop from scratch, it faces a formidable challenge in re-development. Second, a shift by the Government is required from direct provision of basic subsistence toward investment in human capacities. The Government can provide an enabling environment through investments in economic infrastructure and services to business and citizens, thus allowing the population to make productive use of education and their own labor. Both challenges are now being taken up by the Poverty Reduction Strategy, which articulates a detailed set of required actions and outlines priorities for government spending.
