Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents PDF Download

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Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents

Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents PDF Author: Jin Chen
Publisher:
ISBN: 9781109967388
Category : Antineoplastic agents
Languages : en
Pages : 373

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Book Description
A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.