Design, Development and Evaluation of Dual Drug Nanomedicine for Non-small Cell Lung Cancer PDF Download
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Author: Elham Hatami
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Resistance to conventional chemotherapy is a big challenge in the treatment of cancer including non-small cell lung cancer (NSCLC). A combination of natural chemo sensitizer agents with chemotherapy offers unique advantages over monotherapy alone. However, free unbound drugs, (in combination or as a single agent), lack tumor-targeted accumulation and therefore can be easily eliminated from the patient body. Moreover, some drugs are hydrophobic, and their organic solvents cause in vivo toxicity, thereby limiting their capability in clinical translation. Herein, dual loaded biocompatible and biodegradable nanoparticles (NPs) using Gemcitabine (Gem)a pyrimidine nucleoside antimetabolite and Gambogic acid (GA) (a highly hydrophobic chemo sensitizer agent)- were developed on human serum albumin-tannic acid nano-platform (HTA) for targeted treatment of NSCLC. Our in vitro results demonstrate that Gem and GA combination therapy has tremendous potential due to their high efficacy on NSCLC, and GA sensitize NSCLC to Gem therapy. However, GA used in combination with Gem suffers from limited solubility which subsequently leads to a decline in therapeutic efficacy. Therefore, in order to overcome this, in the present study GA and Gem were encapsulated in human serum albumin-tannic acid nanoparticles by the solvent evaporation method. In this platform, HTA is a biocompatible nanocarrier that binds to both GA and Gem. Physico chemical characterizations studies revealed that GA and Gem are successfully encapsulated in HTA NPs with uniform spherical morphology. These nanoparticles were readily taken up by NSCLC cells (A549 and H1299) in a concentration and time-dependent manner. Apart from an increase in GA solubility, encapsulated GA and Gem subsequently manifested elevated therapeutic efficacy, which was confirmed by cell viability, colony formation, migration and invasion studies. Furthermore, in vivo and ex vivo imaging analysis demonstrated notable tumor-targeting behavior of our uniquely designed HTA NPs in mice bearing A549 xenograft tumors. These findings clearly illustrate that our dual loaded NPs can be efficiently utilized to improve cancer therapy and tumor eradication.
Author: Elham Hatami
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Resistance to conventional chemotherapy is a big challenge in the treatment of cancer including non-small cell lung cancer (NSCLC). A combination of natural chemo sensitizer agents with chemotherapy offers unique advantages over monotherapy alone. However, free unbound drugs, (in combination or as a single agent), lack tumor-targeted accumulation and therefore can be easily eliminated from the patient body. Moreover, some drugs are hydrophobic, and their organic solvents cause in vivo toxicity, thereby limiting their capability in clinical translation. Herein, dual loaded biocompatible and biodegradable nanoparticles (NPs) using Gemcitabine (Gem)a pyrimidine nucleoside antimetabolite and Gambogic acid (GA) (a highly hydrophobic chemo sensitizer agent)- were developed on human serum albumin-tannic acid nano-platform (HTA) for targeted treatment of NSCLC. Our in vitro results demonstrate that Gem and GA combination therapy has tremendous potential due to their high efficacy on NSCLC, and GA sensitize NSCLC to Gem therapy. However, GA used in combination with Gem suffers from limited solubility which subsequently leads to a decline in therapeutic efficacy. Therefore, in order to overcome this, in the present study GA and Gem were encapsulated in human serum albumin-tannic acid nanoparticles by the solvent evaporation method. In this platform, HTA is a biocompatible nanocarrier that binds to both GA and Gem. Physico chemical characterizations studies revealed that GA and Gem are successfully encapsulated in HTA NPs with uniform spherical morphology. These nanoparticles were readily taken up by NSCLC cells (A549 and H1299) in a concentration and time-dependent manner. Apart from an increase in GA solubility, encapsulated GA and Gem subsequently manifested elevated therapeutic efficacy, which was confirmed by cell viability, colony formation, migration and invasion studies. Furthermore, in vivo and ex vivo imaging analysis demonstrated notable tumor-targeting behavior of our uniquely designed HTA NPs in mice bearing A549 xenograft tumors. These findings clearly illustrate that our dual loaded NPs can be efficiently utilized to improve cancer therapy and tumor eradication.
Author: Bivash Mandal
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Prashant Kesharwani
Publisher: Academic Press
ISBN: 0128163674
Category : Business & Economics
Languages : en
Pages : 340
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Book Description
Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. Provides an overview of an array of nanotechnology-based drug delivery systems Examines the design, synthesis and application of different nanocarriers in drug and gene delivery Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers
Author: Emilio I. Alarcon
Publisher: Springer Nature
ISBN: 3030312615
Category : Technology & Engineering
Languages : en
Pages : 208
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Book Description
This book fills the gap between fundamental and applied research in the use of nanomaterials in biomedical applications, covering the most relevant areas, such as the fundamental concepts of the preparation of nanostructures and regulatory requirements for their safe use in biomedical devices. It also critically discusses what has been achieved in the field, and what needs to be urgently addressed and reviews the state-of-the-art medical uses of nanomaterials for treating damaged organs and tissues. Combining the expertise of clinical researchers working in the field of tissue engineering and novel materials, the book explores the main topics regarding the characterization of materials, specific organ-oriented biomaterials and their applications, as well as regulations and safety. Further, it also examines recent advances, difficulties, and clinical requirements in terms of human bone, cornea, heart, skin and the nervous system, allowing readers to gain a clear and comprehensive understanding of current nanomaterial use in biomedical applications and devices, together with the challenges and future trends. This book is a valuable tool for multidisciplinary scientists and experts interested in fundamental concepts and synthetic routes for preparing nanomaterials. It is also of interest to students and researchers involved in cross-disciplinary research in nanomaterials for clinical applications and offers practical insights for clinicians as well as engineers and materials scientists working in nanoengineering.
Author: Aamir Ahmad
Publisher: Springer
ISBN: 3319242237
Category : Medical
Languages : en
Pages : 236
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Book Description
This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.
Author:
Publisher: Academic Press
ISBN: 0128141700
Category : Medical
Languages : en
Pages : 224
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Book Description
Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Author: Vinod Kumar Yata
Publisher: Springer Nature
ISBN: 3030471209
Category : Technology & Engineering
Languages : en
Pages : 340
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Book Description
This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
Author: Clare Hoskins
Publisher:
ISBN: 9783039431045
Category :
Languages : en
Pages : 424
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Book Description
This special issue brings together cutting edge research and insightful commentary on the currentl state of the Cancer Nanomedicine field.
Author: Mansoor M. Amiji
Publisher: CRC Press
ISBN: 1000654680
Category : Medical
Languages : en
Pages : 808
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Book Description
While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance fo
Author: Inamuddin
Publisher: Woodhead Publishing
ISBN: 0128137584
Category : Technology & Engineering
Languages : en
Pages : 988
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Book Description
Applications of Nanocomposite in Drug Delivery discusses and explores the applications of nanocomposites in the area of drug delivery. Starting with a scientific understanding of drug delivery fundamentals, the book explores the utility of nanocomposites in the area of controlled, transdermal, osteo-articular tuberculosis and stimulus sensitive drug delivery applications. The book intricately details and discusses a variety of methods for their preparation, while also highlighting specific applications of nanocomposites in targeted drug delivery. Discusses nanocomposite and nanotechnology for drug delivery Outlines the mechanisms involved in targeted drug delivery using nanocomposites Includes synthesis methods for nanocomposites used in controlled drug delivery Lists various applications of nanocomposites in drug delivery
