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Author: Randall E. Harris
Publisher: Springer Science & Business Media
ISBN: 159259302X
Category : Medical
Languages : en
Pages : 641
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Book Description
The revelation that aspirin and aspirin-like compounds have notableantineo plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies. Genetic models are presented confirming the critical role of COX-2 in carcinogenesis. Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen esis, cell division, angiogenesis, cell differentiation, and apoptosis.
Author: Randall E. Harris
Publisher: Springer Science & Business Media
ISBN: 159259302X
Category : Medical
Languages : en
Pages : 641
Get Book Here
Book Description
The revelation that aspirin and aspirin-like compounds have notableantineo plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies. Genetic models are presented confirming the critical role of COX-2 in carcinogenesis. Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen esis, cell division, angiogenesis, cell differentiation, and apoptosis.
Author: K. D. Rainsford
Publisher: John Wiley & Sons
ISBN: 1118743601
Category : Medical
Languages : en
Pages : 624
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Book Description
Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non-inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti-inflammatory and analgesic drugs.
Author: Randall E. Harris
Publisher: Springer
ISBN: 9789048174294
Category : Medical
Languages : en
Pages : 0
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Book Description
In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.
Author: Randall E. Harris
Publisher:
ISBN: 9781468497243
Category :
Languages : en
Pages : 384
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Book Description
Author: K. D. Rainsford
Publisher: John Wiley & Sons
ISBN: 1118743385
Category : Medical
Languages : en
Pages : 620
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Book Description
Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non-inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti-inflammatory and analgesic drugs.
Author: Randall E. Harris
Publisher: Springer Science & Business Media
ISBN: 1402056885
Category : Medical
Languages : en
Pages : 323
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Book Description
In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.
Author: Nima Rezaei
Publisher: Springer
ISBN: 3662464101
Category : Medical
Languages : en
Pages : 522
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Book Description
Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume focuses on the immunopathology and immunotherapy of organ cancers in detail. It clearly explains their immunology and describes novel immunotherapy for specific cancers, including pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, skin cancers, bone and connective tissue tumors, central nervous system tumors, lung cancers, genitourinary tract tumors and breast cancers. In so doing, it builds on the previous two volumes in Cancer Immunology, placing basic knowledge on tumor immunology and immunotherapy into a clinical perspective with the aim of educating clinicians on advances in cancer immunology and the most recent approaches in the immunotherapy of various tumors. This translational, clinically oriented book will be of special value to clinical immunologists, hematologists and oncologists.
Author: Randall E. Harris
Publisher: Jones & Bartlett Learning
ISBN: 1284151018
Category : Medical
Languages : en
Pages : 957
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Book Description
Epidemiology of Chronic Disease: Global Perspectives is the most current and authoritative resource on the epidemiology, etiology, pathogenesis, risk factors and preventive factors of over 50 major chronic diseases and conditions. This comprehensive text provides readers with an excellent basis for examining current hypotheses regarding chronic disease epidemiology.
Author: Randall E. Harris
Publisher: Jones & Bartlett Publishers
ISBN: 1284034453
Category : Education
Languages : en
Pages : 444
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Book Description
In 28 chapters, Global Epidemiology of Cancer provides a basic overview of the most commonly occurring cancers, their worldwide incidence, and mortality. Designed for the health sciences, particularly those in epidemiology, public health, and medicine, this comprehensive resource is ideal as a primary text for an overview course or seminar on Cancer or Cancer epidemiology. Key Features: - Backed with research and draws upon worldwide information to address the global landscape of cancer. - Offers clear, concise descriptions of each specific type of oncologic disease as well as its epidemiology, etiology, risk factors and preventive factors - Includes a wealth of information on the pathogenesis of the disease as we currently understand it at the molecular level.
Author: Jens Jørgen Pindborg
Publisher: Butterworth-Heinemann
ISBN:
Category : Medical
Languages : en
Pages : 200
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Book Description
