CONTRIBUTION TO THE ELABORATION OF THE GENETIC MAP OF THE HUMAN X CHROMOSOME: CHARACTERIZATION OF NEW ADN-BASED GENETIC MARKERS CALLED MICROSATELLITES PDF Download
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Author: Pau Roustan
Publisher:
ISBN:
Category :
Languages : en
Pages : 284
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Book Description
LE PROGRAMME DE CARTOGRAPHIE ET SEQUENCAGE DU GENOME HUMAIN OUVRE DEJA D'IMMENSES PERSPECTIVES A LA MEDECINE MAIS DEVRAIT AUSSI APPORTER SON LOT DE SURPRISES QUANT AUX ETUDES MENEES SUR LA STRUCTURE, L'EXPRESSION, LA FONCTION ET L'EVOLUTION DE NOTRE PATRIMOINE GENETIQUE. LE GENOME HUMAIN CONTIENT 50000 A 100000 COPIES D'UNE SEQUENCE HAUTEMENT DISPERSEE DU TYPE (DC.DA)N/(DG.DT)N POUR LAQUELLE N PEUT VARIER D'UN CHROMOSOME A L'AUTRE POUR UN LOCUS DONNE. LA REPARTITION REGULIERE DE CES REPETITIONS DE DINUCLEOTIDES LE LONG DES CHROMOSOMES ET LE FAIT QUE CES SEQUENCES SONT FACILEMENT ANALYSABLES PAR LA REACTION D'AMPLIFICATION GENIQUE, FONT DE CES DERNIERES, AUSSI APPELEES MICRO-SATELLITES, DES MARQUEURS GENETIQUES DU PLUS HAUT INTERET. LE TRAVAIL PRESENTE DANS CETTE THESE SE VOUDRAIT ETRE UNE CONTRIBUTION A LA CONSTRUCTION D'UNE CARTE HAUTE DEFINITION DU CHROMOSOME X HUMAIN GRACE A L'EMPLOI DE TELS MARQUEURS HAUTEMENT POLYMORPHIQUES. APRES QUELQUES RAPPELS CONCERNANT L'ETAT ACTUEL DE LA GENETIQUE HUMAINE, SONT PRESENTES A PARTIR D'UNE BANQUE DE COSMIDES SPECIFIQUES DU CHROMOSOME X HUMAIN, LE CLONAGE, LE SEQUENCAGE ET LA DETERMINATION DU DEGRE DE POLYMORPHISME DE SIX MICRO-SATELLITES. LES LOCALISATIONS PHYSIQUE ET GENETIQUE DE CERTAINS D'ENTRE EUX PROLONGENT LE TRAVAIL DE CARACTERISATION DE CES SEQUENCES. ENFIN LES POSSIBLES DEVELOPPEMENTS DE CE TRAVAIL CONCERNANT LA CARTE DU CHROMOSOME X ET L'IDENTIFICATION DE GENES RESPONSABLES DE MALADIES HEREDITAIRES, SONT BRIEVEMENT ABORDES AU TRAVERS DE QUELQUES EXEMPLES D'APPLICATION
Author: Pau Roustan
Publisher:
ISBN:
Category :
Languages : en
Pages : 284
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Book Description
LE PROGRAMME DE CARTOGRAPHIE ET SEQUENCAGE DU GENOME HUMAIN OUVRE DEJA D'IMMENSES PERSPECTIVES A LA MEDECINE MAIS DEVRAIT AUSSI APPORTER SON LOT DE SURPRISES QUANT AUX ETUDES MENEES SUR LA STRUCTURE, L'EXPRESSION, LA FONCTION ET L'EVOLUTION DE NOTRE PATRIMOINE GENETIQUE. LE GENOME HUMAIN CONTIENT 50000 A 100000 COPIES D'UNE SEQUENCE HAUTEMENT DISPERSEE DU TYPE (DC.DA)N/(DG.DT)N POUR LAQUELLE N PEUT VARIER D'UN CHROMOSOME A L'AUTRE POUR UN LOCUS DONNE. LA REPARTITION REGULIERE DE CES REPETITIONS DE DINUCLEOTIDES LE LONG DES CHROMOSOMES ET LE FAIT QUE CES SEQUENCES SONT FACILEMENT ANALYSABLES PAR LA REACTION D'AMPLIFICATION GENIQUE, FONT DE CES DERNIERES, AUSSI APPELEES MICRO-SATELLITES, DES MARQUEURS GENETIQUES DU PLUS HAUT INTERET. LE TRAVAIL PRESENTE DANS CETTE THESE SE VOUDRAIT ETRE UNE CONTRIBUTION A LA CONSTRUCTION D'UNE CARTE HAUTE DEFINITION DU CHROMOSOME X HUMAIN GRACE A L'EMPLOI DE TELS MARQUEURS HAUTEMENT POLYMORPHIQUES. APRES QUELQUES RAPPELS CONCERNANT L'ETAT ACTUEL DE LA GENETIQUE HUMAINE, SONT PRESENTES A PARTIR D'UNE BANQUE DE COSMIDES SPECIFIQUES DU CHROMOSOME X HUMAIN, LE CLONAGE, LE SEQUENCAGE ET LA DETERMINATION DU DEGRE DE POLYMORPHISME DE SIX MICRO-SATELLITES. LES LOCALISATIONS PHYSIQUE ET GENETIQUE DE CERTAINS D'ENTRE EUX PROLONGENT LE TRAVAIL DE CARACTERISATION DE CES SEQUENCES. ENFIN LES POSSIBLES DEVELOPPEMENTS DE CE TRAVAIL CONCERNANT LA CARTE DU CHROMOSOME X ET L'IDENTIFICATION DE GENES RESPONSABLES DE MALADIES HEREDITAIRES, SONT BRIEVEMENT ABORDES AU TRAVERS DE QUELQUES EXEMPLES D'APPLICATION
Author: Andrew James Donnelly
Publisher:
ISBN:
Category :
Languages : en
Pages : 740
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Book Description
The aim of the project presented in this thesis is to isolate microsatellite markers and to construct a high resolution genetic map of the human X chromosome using these and pre-existing microsatellite markers. AC dinucleotide repeat markers are isolated from a bacteriophage library for application to the genetic localisations of X-linked disease genes, particularly those responsible for non-specific mental retardation (MRX). The genetic map is used to refine the location of the disease gene segregating in five families affected with X-linked mental retardation.
Author: Swarup Kumar Chakrabarti
Publisher: Springer
ISBN: 3319661353
Category : Science
Languages : en
Pages : 332
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Book Description
This book describes the historical importance of potato (Solanum tuberosum L.),potato genetic resources and stocks (including S. tuberosum group Phureja DM1-3 516 R44, a unique doubled monoploid homozygous line) used for potato genome sequencing. It also discusses strategies and tools for high-throughput sequencing, sequence assembly, annotation, analysis, repetitive sequences and genotyping-by-sequencing approaches. Potato (Solanum tuberosum L.; 2n = 4x = 48) is the fourth most important food crop of the world after rice, wheat and maize and holds great potential to ensure both food and nutritional security. It is an autotetraploid crop with complex genetics, acute inbreeding depression and a highly heterozygous nature. Further, the book examines the recent discovery of whole genome sequencing of a few wild potato species genomes, genomics in management and genetic enhancement of Solanum species, new strategies towards durable potato late blight resistance, structural analysis of resistance genes, genomics resources for abiotic stress management, as well as somatic cell genetics and modern approaches in true-potato-seed technology. The complete genome sequence provides a better understanding of potato biology, underpinning evolutionary process, genetics, breeding and molecular efforts to improve various important traits involved in potato growth and development.
Author: David B. Goldstein
Publisher: Oxford University Press on Demand
ISBN: 9780198504078
Category : Science
Languages : en
Pages : 352
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Book Description
Microsatellites are short stretches of repeated DNA, found in most genomes, that show exceptional variability in humans and most other species. This variability has made microsatellites the genetic marker of choice for most applications, including genetic mapping and studies of the evolutionary connections between species and populations. This book brings together an international group of scientists currently working in microsatellites. Their contributions provide a detailed descriptionof microsatellite biology, focusing on their mutation properties, generation, decay, and possible functional roles. They introduce the theoretical models that underpin the most popular methods for analysing the information that microsatellites can yield, including methods for estimating coalescent times, population divergences, and migration. Finally, the book describes the various ways in which the potential of microsatellites is being harnessed in a range of applications including medical genetics, forensics, genetic mapping, the analysis of human evolution, and conservation genetics.
Author: David D Celentano
Publisher: Elsevier Health Sciences
ISBN: 0323552315
Category : Medical
Languages : en
Pages : 434
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Book Description
From the Department of Epidemiology at Johns Hopkins University and continuing in the tradition of award-winning educator and epidemiologist Dr. Leon Gordis, comes the fully revised 6th Edition of Gordis Epidemiology. This bestselling text provides a solid introduction to basic epidemiologic principles as well as practical applications in public health and clinical practice, highlighted by real-world examples throughout. New coverage includes expanded information on genetic epidemiology, epidemiology and public policy, and ethical and professional issues in epidemiology, providing a strong basis for understanding the role and importance of epidemiology in today's data-driven society. - Covers the basic principles and concepts of epidemiology in a clear, uniquely memorable way, using a wealth of full-color figures, graphs, charts, and cartoons to help you understand and retain key information. - Reflects how epidemiology is practiced today, with a new chapter organization progressing from observation and developing hypotheses to data collection and analyses. - Features new end-of-chapter questions for quick self-assessment, and a glossary of genetic terminology. - Provides more than 200 additional multiple-choice epidemiology self-assessment questions online. - Evolve Instructor Resources, including a downloadable image and test bank, are available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com
Author: Jeffrey Bennetzen
Publisher: Springer
ISBN: 3319974270
Category : Science
Languages : en
Pages : 390
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Book Description
This book discusses advances in our understanding of the structure and function of the maize genome since publication of the original B73 reference genome in 2009, and the progress in translating this knowledge into basic biology and trait improvement. Maize is an extremely important crop, providing a large proportion of the world’s human caloric intake and animal feed, and serving as a model species for basic and applied research. The exceptionally high level of genetic diversity within maize presents opportunities and challenges in all aspects of maize genetics, from sequencing and genotyping to linking genotypes to phenotypes. Topics covered in this timely book range from (i) genome sequencing and genotyping techniques, (ii) genome features such as centromeres and epigenetic regulation, (iii) tools and resources available for trait genomics, to (iv) applications of allele mining and genomics-assisted breeding. This book is a valuable resource for researchers and students interested in maize genetics and genomics.
Author: Ken Overturf
Publisher: John Wiley & Sons
ISBN: 0813807425
Category : Technology & Engineering
Languages : en
Pages : 407
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Book Description
Molecular Research in Aquaculture Molecular research and biotechnology have long been fields of study with applications useful to aquaculture and other animal sciences. Molecular Research in Aquaculture looks to provide an understanding of molecular research and its applications to the aquaculture industry in a format that allows individuals without prior experience in this area to learn about and understand this important field. Molecular Research in Aquaculture opens with an introductory chapter giving background information on the aquaculture industry and the development of the science and research methods to what is currently being used. From there it discusses how new, innovative techniques are now being converted and used for research in this field. Introductory chapters on basic molecular biological techniques, such as PCR, cloning, and hybridization, and their rationale provide the foundation for an in-depth look at molecular research and its specific applications. The remaining chapters review key areas of molecular research such as microarray analysis, quantitative PCR, and transgenics. Molecular Research in Aquaculture will be a valuable reference for professionals and researchers with an interest in the development of molecular technologies and their applications to the field of aquaculture. Coverage of basic molecular biological techniques and their rationale In-depth look at molecular research and their applications to aquaculture Valuable reference on the developments of this key area in aquaculture research
Author: R.L. Phillips
Publisher: Springer Science & Business Media
ISBN: 9401598150
Category : Science
Languages : en
Pages : 508
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Book Description
With the new techniques described in this volume, a new gene can be placed on the linkage map within only a few days. Leading researchers have updated the earlier edition to include the latest versions of DNA-based marker maps for a variety of important crops.
Author: Jean-Nicolas Volff
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805584911
Category : Medical
Languages : en
Pages : 155
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Book Description
Recent major advances in the field of comparative genomics and cytogenomics of plants, particularly associated with the completion of ambitious genome projects, have uncovered astonishing facets of the architecture and evolutionary history of plant genomes. The aim of this book was to review these recent developments as well as their implications in our understanding of the mechanisms which drive plant diversity. New insights into the evolution of gene functions, gene families and genome size are presented, with particular emphasis on the evolutionary impact of polyploidization and transposable elements. Knowledge on the structure and evolution of plant sex chromosomes, centromeres and microRNAs is reviewed and updated. Taken together, the contributions by internationally recognized experts present a panoramic overview of the structural features and evolutionary dynamics of plant genomes.This volume of Genome Dynamics will provide researchers, teachers and students in the fields of biology and agronomy with a valuable source of current knowledge on plant genomes.
Author: Jacqueline Batley
Publisher: Humana
ISBN: 9781493943678
Category : Science
Languages : en
Pages : 0
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Book Description
The ability to produce vast amounts of DNA sequence data has enabled the discovery of molecular markers in model organisms, crops, as well as orphan species making genotyping the rate limiting factor, and this volume focuses on the different markers available and the low to high throughput genotyping of these markers. Given the diverse nature of some of these systems, an overview is provided on the identification of markers from sequence data, as well as data analysis with example applications once the genotyping data has been generated. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Plant Genotyping: Methods and Protocols is aimed at plant molecular biologists, geneticists, plant breeders and ecologists who have a target question and need to know the most suitable markers and genotyping system to use.
