Computational Studies on Ageing and Age-related Diseases PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Computational Studies on Ageing and Age-related Diseases PDF full book. Access full book title Computational Studies on Ageing and Age-related Diseases by Handan Melike Donertas. Download full books in PDF and EPUB format.
Author: Handan Melike Donertas
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Handan Melike Donertas
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Stanley Durrleman
Publisher: Frontiers Media SA
ISBN: 2889767663
Category : Science
Languages : en
Pages : 140
Get Book Here
Book Description
Author: Stephen Bondy
Publisher: Springer Science & Business Media
ISBN: 1607616025
Category : Medical
Languages : en
Pages : 468
Get Book Here
Book Description
Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.
Author: A.I. Yashin
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318027308
Category : Medical
Languages : en
Pages : 208
Get Book Here
Book Description
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
Author: Andres Kriete
Publisher: Elsevier Inc. Chapters
ISBN: 0128070188
Category : Medical
Languages : en
Pages : 33
Get Book Here
Book Description
What makes the study of aging particularly challenging is the wide spectrum of phenotypical changes that can be observed during its progression. While initial attention was paid to damage accumulation, dysfunction, and failure, it is now realized that aging, and associated diseases including dementias, are influenced by a multitude of interacting factors. Proximal mechanisms beyond passive accumulation of damage include regulatory mechanisms, stress responses, changes in networks, as well as genetic and stochastic effects. The application of computational systems biology in aging, which is in line with other attempts to overcome the study of isolated or compartmentalized mechanisms, has made initial progress allowing us to simulate partial aspects of the aging dynamics and to make new hypotheses about how these aging mechanism shape disease progression. Here we provide examples for analysis of networks, regulatory mechanisms, and spatiotemporal effects in the study of proximal mechanisms of aging and Parkinson’s Disease. In addition, we introduce complexity theories that may contribute to explain the ultimate causes of aging with an evolutionary view.
Author: David Evered
Publisher: John Wiley & Sons
ISBN:
Category : Family & Relationships
Languages : en
Pages : 288
Get Book Here
Book Description
A collection of papers focusing on the contribution biomedical research can make to the provision of proper health care for the elderly, both in industrialized and in developing societies.
Author: Suresh I.S. Rattan
Publisher: Springer
ISBN: 9789048172177
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
This book offers a broad-ranging assessment of current efforts of the molecular, cellular, hormonal, nutritional and lifestyle strategies being tested and applied by biogerontologists in the search for effective means of intervention, prevention and treatment of age-related diseases, and for achieving healthy old age. Employing a semi-academic style, the book presents data from experimental systems, while focusing primarily on their applications to humans in the prevention and treatment of age-related impairments.
Author: Andrew Steele
Publisher: Anchor
ISBN: 0385544936
Category : Science
Languages : en
Pages : 353
Get Book Here
Book Description
“A fascinating look at how scientists are working to help doctors treat the aging process itself, helping us all to lead longer, healthier lives.” —Sanjay Gupta, MD Aging—not cancer, not heart disease—is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: there are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are, a phenomenon known as “biological immortality.” In Ageless, Andrew Steelecharts the astounding progress science has made in recent years to secure the same for humans: to help us become old without getting frail, to live longer without ill health or disease.
Author: Dante G. Scarpelli
Publisher: Alan R. Liss
ISBN:
Category : Medical
Languages : en
Pages : 472
Get Book Here
Book Description
Author: G. Pepeu
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 256
Get Book Here
Book Description
